{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:04:55Z","timestamp":1760015095749},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"586","license":[{"start":{"date-parts":[[1974,8,1]],"date-time":"1974-08-01T00:00:00Z","timestamp":144547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1974,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We describe two patients with very severe arterial hypertension, who were treated vigorously and effectively with hypotensive drugs. Both promptly developed gross neurological abnormalities, yet recovered fully after treatment with dexamethasone. We have found no similar published reports. We believe that these cases illustrate an important risk of treatment of severe hypertension, and we suggest that cerebral oedema developed, and was then relieved by dexamethasone.<\/jats:p>","DOI":"10.1136\/pgmj.50.586.517","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"517-519","source":"Crossref","is-referenced-by-count":2,"title":["Coma following treatment of very severe arterial hypertension, with improvement after dexamethasone therapy"],"prefix":"10.1093","volume":"50","author":[{"given":"L J","family":"Farrow","sequence":"first","affiliation":[{"name":"Division of Medicine, St Mary\u2019s Hospital , London W.2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J B","family":"Wood","sequence":"additional","affiliation":[{"name":"Division of Medicine, St Mary\u2019s Hospital , London W.2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1974,8,1]]},"reference":[{"key":"ref_1","article-title":"The pathogenesis of hypertensive encephalopathy and its relation to the malignant phase of hypertension","volume":"ii,","author":"BYROM, F.B.","year":"1954","unstructured":"BYROM, F.B. (1954) The pathogenesis of hypertensive encephalopathy and its relation to the malignant phase of hypertension. Lancet, ii, 201.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/0002-9149(66)90393-6","article-title":"Cerebrovascular consequences of hypertension-therapeutic complications","volume":"17","author":"FAZEKAS, J.F.","year":"1966","unstructured":"FAZEKAS, J.F. (1966) Cerebrovascular consequences of hypertension-therapeutic complications. American Journal of Cardiology, 17, 608.","journal-title":"American Journal of Cardiology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1172\/JCI102997","article-title":"Cerebral hemodynamics during cerebral ischaemia induced by acute hypotension","volume":"33","author":"YOUNG, W.K.","year":"1954","unstructured":"& YOUNG, W.K. (1954) Cerebral hemodynamics during cerebral ischaemia induced by acute hypotension. Journal of clinical Investigation, 33, 1227.","journal-title":"Journal of clinical Investigation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1136\/bmj.1.5852.507","article-title":"Autoregulation of brain circulation in severe arterial hypertension","volume":"1","author":"STRANDGAARD, S.; OLESEN, J.; SKINHOJ, E.; LASSEN, N.A.","year":"1973","unstructured":"STRANDGAARD, S., OLESEN, J., SKINHOJ, E. & LASSEN, N.A. (1973) Autoregulation of brain circulation in severe arterial hypertension. British Medical Journal, 1, 507.","journal-title":"British Medical Journal"},{"key":"ref_5","first-page":"519","article-title":"Postgraduate Medical Journal","volume":"50","year":"1974","unstructured":"Postgraduate Medical Journal (August 1974) 50, 519-520."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/50\/586\/517\/50254344\/postgradmedj-50-517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/50\/586\/517\/50254344\/postgradmedj-50-517.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T09:35:37Z","timestamp":1684229737000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/50\/586\/517\/7064437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,8,1]]},"references-count":5,"journal-issue":{"issue":"586","published-online":{"date-parts":[[1974,8,1]]},"published-print":{"date-parts":[[1974,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.50.586.517","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1974,8]]},"published":{"date-parts":[[1974,8,1]]}}}