{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T20:39:29Z","timestamp":1718656769130},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"591","license":[{"start":{"date-parts":[[1975,1,1]],"date-time":"1975-01-01T00:00:00Z","timestamp":157766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A patient with Cushing\u2019s syndrome due to an adrenocortical carcinoma is described. Treatment of residual disease and functional metastases was attempted with o,p\u2032-DDD and later aminoglutethimide. Aminoglutethimide in a daily dose of 1 g appeared to have little effect additional to o,p\u2032-DDD. It is important to maintain replacement therapy with cortico-steroids throughout the use of these drugs.<\/jats:p>","DOI":"10.1136\/pgmj.51.591.35","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"35-37","source":"Crossref","is-referenced-by-count":28,"title":["Treatment of an adrenal cortical carcinoma with a combination of o,p\u2032-DDD and aminoglutethimide"],"prefix":"10.1093","volume":"51","author":[{"given":"R D M","family":"Scott","sequence":"first","affiliation":[{"name":"Department of Medicine, Western General Hospital , Edinburgh EH4 2XU"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1975,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"672","DOI":"10.7326\/0003-4819-53-4-672","article-title":"Chemotherapy of adrenocortical carcinoma","volume":"53","author":"BERGENSTAL, D.M.; HERTZ, R.; LIPSETT, M.B.; MAY, R.H.","year":"1960","unstructured":"BERGENSTAL, D.M., HERTZ, R., LIPSETT, M.B. & MAY, R.H. (1960) Chemotherapy of adrenocortical carcinoma with o,p'-DDD. Annals of Internal Medicine, 53, 672.","journal-title":"Annals of Internal Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"809","DOI":"10.5694\/j.1326-5377.1969.tb105543.x","article-title":"p'-DDD and aminoglutethimide on metastatic adrenal carcinoma","volume":"1","author":"BOCHNER, F.; LLOYD, H.M.; ROESER, H.P.; THOMAS, M.J.","year":"1969","unstructured":"BOCHNER, F., LLOYD, H.M., ROESER, H.P. & THOMAS, M.J. (1969) Effects of o,p'-DDD and aminoglutethimide on metastatic adrenal carcinoma. 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Medizinische Klinik, 62, 556.","journal-title":"Medizinische Klinik"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/clinchem\/17.12.1191","article-title":"Metastatic adrenal cortical carcinoma: Biochemical changes accompanying clinical regression during therapy","volume":"17","author":"HELSON, L.; WOLLNER, N.; MURPHY, L.","year":"1971","unstructured":"HELSON, L., WOLLNER, N. & MURPHY, L. (1971) Metastatic adrenal cortical carcinoma: Biochemical changes accompanying clinical regression during therapy with o,p'-DDD. Clinical Chemistry, 17, 1191.","journal-title":"Clinical Chemistry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/0002-9343(66)90219-1","article-title":"Adrenal cortical carcinoma: Clinical features of 138 patients","volume":"41","author":"HUTTER, A.M.; KAYHOE, D.","year":"1966","unstructured":"HUTTER, A.M., KAYHOE, D. (1966a) Adrenal cortical carcinoma: Clinical features of 138 patients. 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(1967) Effects of aminoglutethimide upon adrenal function and cortisol metabolism in Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism, 27, 1657.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1056\/NEJM196910092811501","article-title":"Correction of hypercortisolism by o, p'-DDD without indication of aldosterone deficiency","volume":"281","author":"TEMPLE, T.E.; JONES, D.J.; LIDDLE, G.W.; DEXTER, R.N.","year":"1969","unstructured":"TEMPLE, T.E., JONES, D.J., LIDDLE, G.W. & DEXTER, R.N. (1969) Correction of hypercortisolism by o,p'-DDD without indication of aldosterone deficiency. 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Endocrinology, 65, 80.","journal-title":"Endocrinology"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/51\/591\/35\/50257549\/postgradmedj-51-35.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/51\/591\/35\/50257549\/postgradmedj-51-35.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T11:02:09Z","timestamp":1684234929000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/51\/591\/35\/7064068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,1,1]]},"references-count":15,"journal-issue":{"issue":"591","published-online":{"date-parts":[[1975,1,1]]},"published-print":{"date-parts":[[1975,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.51.591.35","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1975,1]]},"published":{"date-parts":[[1975,1,1]]}}}