{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:10:19Z","timestamp":1709867419496},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"591","license":[{"start":{"date-parts":[[1975,1,1]],"date-time":"1975-01-01T00:00:00Z","timestamp":157766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,1,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Various kinds of dysrhythmias are found in association with hyperthyroidism but especially atrial fibrillation. The causal relationship of chronic atrial fibrillation and the endocrine disorder is controversial, as is its therapeutic management. Six patients with this particular combination of disorders were treated with lidoflazine: a new anti-anginal drug with anti-arrhythmic activity. All six patients returned to sinus rhythm on lidoflazine treatment although still hyperthyroid and remained in sinus rhythm during the follow up period ranging from 5 to 14 months. This occurred independently of antithyroid treatment. Some evidence is put forward that dysrhythmias and most commonly chronic atrial fibrillation are triggered off by hyperthyroidism or other disorders but that they are maintained by permanent cardiac damage due to arteriosclerosis, hypertension, coronary heart disease or rheumatic valve disease.<\/jats:p><jats:p>Successful chemical cardioversions and maintenance of sinus rhythm can be obtained independent of the thyroid function. Our results confirm the anti-arrhythmic activity of lidoflazine.<\/jats:p>","DOI":"10.1136\/pgmj.51.591.4","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"4-9","source":"Crossref","is-referenced-by-count":2,"title":["Atrial fibrillation and hyperthyroidism: a new look at their relationship and therapy with lidoflazine"],"prefix":"10.1093","volume":"51","author":[{"given":"K","family":"Bruyneel","sequence":"first","affiliation":[{"name":"Clinical Research Unit, St Bartholomeus Hospital , B-2060 Merksem, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Verhaegen","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, St Bartholomeus Hospital , B-2060 Merksem, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ch","family":"De Vil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, H. Hartziekenhuis , B-2500 Lier, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1975,1,1]]},"reference":[{"key":"ref_1","first-page":"321","article-title":"Lidoflazine na angina do peito: 1. Ensaio duplamente cego","volume":"21","author":"BATLOUNI, M.; BERTOLAMI, V.; DUPRAT, R.","year":"1968","unstructured":"BATLOUNI, M., BERTOLAMI, V. & DUPRAT, R. (1968) Lidoflazine na angina do peito: 1. Ensaio duplamente cego. Arquivos Brasileiros de Cardiologia, 21, 321.","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"ref_2","first-page":"31","article-title":"Electrocardiografic aspects of lidoflazine treatment in patients","volume":"16","author":"BATLOUNI, M.","year":"1965","unstructured":"BATLOUNI, M. Electrocardiografic aspects of lidoflazine treatment in patients with a,rial fibrillation. Janssen Pharmaceutica (internal report). BENCHIMOL, A., LOWE, H.M. & AKRE, P.R. (1965) Cardiovascular response to exercise during atrial fibrillation and after conversion to sinus rhythm. American Journal of Cardiology, 16, 31.","journal-title":"American Journal of Cardiology; Cardiovascular response to exercise during atrial fibrillation and after conversion to sinus rhythm"},{"key":"ref_3","first-page":"483","article-title":"Lidoflazine, a new drug in the treatment of angina pectoris","volume":"14","author":"BERNSTEIN, V.; PERETZ, D.I.","year":"1972","unstructured":"BERNSTEIN, V. & PERETZ, D.I. (1972) Lidoflazine, a new drug in the treatment of angina pectoris. Current Therapeutic Research, 14, 483.","journal-title":"Current Therapeutic Research"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1001\/jama.1960.73020340015019c","article-title":"Prolongation of the PR interval as a manifestation of thyrotoxicosis","volume":"173","author":"BLIZZARD, J.J.; RUPP, J.J.","year":"1960","unstructured":"BLIZZARD, J.J. & RUPP, J.J. (1960) Prolongation of the PR interval as a manifestation of thyrotoxicosis. Journal of the American Medical Association, 173, 1845.","journal-title":"Journal of the American Medical Association"},{"key":"ref_5","first-page":"1031","article-title":"Elektrokardiographische Befunde bei","volume":"48","author":"BOCK, D.; KLEIN, E.","year":"1972","unstructured":"BOCK, D. & KLEIN, E. (1972) Elektrokardiographische Befunde bei Hyperthyreosen. Zeitschrift fur Allgemein Medizin\/Der Landarzt, 48, 1031."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0002-8703(45)90448-0","article-title":"Ventricular fibrillation as a complication of hyperthyroidism","volume":"29","author":"BOONE, J.A.","year":"1945","unstructured":"BOONE, J.A. (1945) Ventricular fibrillation as a complication of hyperthyroidism. 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