{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T17:07:13Z","timestamp":1698167233280},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"592","license":[{"start":{"date-parts":[[1975,2,1]],"date-time":"1975-02-01T00:00:00Z","timestamp":160444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>This is the first report of two brothers who demonstrated the classical clinical course, histology, biochemistry and auto-antibodies of primary biliary cirrhosis. Both also exhibited an associated keratoconjunctivitis sicca and, in one, renal tubular acidosis resulted in severe systemic acidosis after lactulose therapy and with a subsequent intraperitoneal variceal rupture.<\/jats:p>\n               <jats:p>Screening of the relatives recalled a high incidence of \u2018auto-immune\u2019 disease and auto-antibodies.<\/jats:p>","DOI":"10.1136\/pgmj.51.592.110","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"110-115","source":"Crossref","is-referenced-by-count":16,"title":["Primary biliary cirrhosis in brothers"],"prefix":"10.1093","volume":"51","author":[{"given":"R","family":"Bown","sequence":"first","affiliation":[{"name":"The Department of Medicine, St Bartholomew\u2019s Hospital, and The Department of Immunopathology, The Middlesex Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L","family":"Clark","sequence":"additional","affiliation":[{"name":"The Department of Medicine, St Bartholomew\u2019s Hospital, and The Department of Immunopathology, The Middlesex Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Doniach","sequence":"additional","affiliation":[{"name":"The Department of Medicine, St Bartholomew\u2019s Hospital, and The Department of Immunopathology, The Middlesex Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1975,2,1]]},"reference":[{"key":"ref_1","first-page":"863","article-title":"The production and transport of ammonia in the human colon","volume":"12","author":"BoWN, R.L.; SLADEN, G.E.; CLARK, M.L.; DAWSON, A.M.","year":"1971","unstructured":"BoWN, R.L., SLADEN, G.E., CLARK, M.L. & DAWSON, A.M. (1971) The production and transport of ammonia in the human colon. Gut, 12, 863.","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/gut.14.3.213","article-title":"Primary biliary cirrhosis in twin sisters","volume":"14","author":"CHOHAN, M.R.","year":"1973","unstructured":"CHOHAN, M.R. (1973) Primary biliary cirrhosis in twin sisters. Gut, 14, 213.","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"330","DOI":"10.7326\/0003-4819-65-2-330","article-title":"Benign recurrent intrahepatic cholestasis in two brothers","volume":"65","author":"SILVA, D.A.; C., L.; BRITO, D.E.; T.","year":"1966","unstructured":"DA SILVA, L.C. & DE BRITO, T. (1966) Benign recurrent intrahepatic cholestasis in two brothers. Annals of Internal Medicine, 65, 330.","journal-title":"Annals of Internal Medicine"},{"key":"ref_4","article-title":"A classification of chronic hepatitis","volume":"626","author":"GROOTE, D.E.; J., D.E.S.M.E.T.; J., V.; GEDICK, P.; KORB, G.; PEPPER, H.; POULSEN, H.; SCHEUER, P.J.; SCHMID, M.; THALER, H.; UEHLINGER, E.; WEPLER, W.","year":"1968","unstructured":"DE GROOTE, J., DESMET, V.J., GEDICK, P., KORB, G., PEPPER, H., POULSEN, H., SCHEUER, P.J., SCHMID, M., THALER, H., UEHLINGER, E. & WEPLER, W. (1968) A classification of chronic hepatitis. Lancet, ii, 626.","journal-title":"Lancet"},{"key":"ref_5","first-page":"493","article-title":"Epidemic hepatitis-associated antigen","volume":"106","author":"PRETE, D.E.L.; S., C.O.S.T.A.N.T.I.N.O.; D., D.O.G.L.I.A.; M., F.A.B.I.A.N.I.; P., M.; BORIN, R.","year":"1972","unstructured":"DEL PRETE, S., COSTANTINO, D., DOGLIA, M., FABIANI, M.P. & BORIN, R. (1972) Epidemic hepatitis-associated antigen. Canadian Medical Association Journal, 106, 493.","journal-title":"Canadian Medical Association Journal"},{"key":"ref_6","first-page":"237","article-title":"Tissue antibodies in primary biliary cirrhosis, chronic active hepatitis, cryptogenic cirrhosis and other liver diseases, and their clinical implications","volume":"1","author":"DONIACH, D.; Roirr, I.M.; WALKER, J.G.; SHERLOCK, S.","year":"1966","unstructured":"DONIACH, D., Roirr, I.M., WALKER, J.G. & SHERLOCK, S. (1966) Tissue antibodies in primary biliary cirrhosis, chronic active hepatitis, cryptogenic cirrhosis and other liver diseases, and their clinical implications. Clinical and Experimental Immunology, 1, 237.","journal-title":"Clinical and Experimental Immunology"},{"key":"ref_7","first-page":"609","article-title":"Mitochondrial and other tissue antibodies in relatives of patients with primary biliary cirrhosis","volume":"10","author":"FEIZI, T.; NACCARATO, R.; SHERLOCK, S.; DONIACH, D.","year":"1972","unstructured":"FEIZI, T., NACCARATO, R., SHERLOCK, S. & DONIACH, D. (1972) Mitochondrial and other tissue antibodies in relatives of patients with primary biliary cirrhosis. Clinical and Experimental Immunology, 10, 609.","journal-title":"Clinical and Experimental Immunology"},{"key":"ref_8","first-page":"245","article-title":"In: Diseases of the Liver","author":"FOULK, W.T.; BAGGENSTOSS, A.H.","year":"1969","unstructured":"FOULK, W.T. & BAGGENSTOSS, A.H. (1969) In: Diseases of the Liver (Ed. by L. Schiff), p. 245. J. B. Lippincott: Philadelphia."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1056\/NEJM197401102900201","article-title":"High prevalence of seroimmunologic abnormalities in relatives of patients with active chronic hepatitis or primary biliary cirrhosis","volume":"290","author":"GALBRAITH, R.M.; SMITH, G.M.; MCKENZIE, R.M.; DONIACH, D.; WILLIAMS, R.; TEE, D.S.","year":"1974","unstructured":"GALBRAITH, R.M., SMITH, G.M., MCKENZIE, R.M., DONIACH, D., WILLIAMS, R. & TEE, D.S. (1974) High prevalence of seroimmunologic abnormalities in relatives of patients with active chronic hepatitis or primary biliary cirrhosis. New England Journal of Medicine, 290, 63.","journal-title":"New England Journal of Medicine"},{"key":"ref_10","first-page":"194","article-title":"Studies on multi-system involvement in active chronic hepatitis and primary biliary cirrhosis. In: Immunology of the Liver","author":"GOLDING, P.L.; BOWN, R.; STUART-MASON, A.","year":"1970","unstructured":"GOLDING, P.L., BOWN, R. & STUART-MASON, A. (1970a) Studies on multi-system involvement in active chronic hepatitis and primary biliary cirrhosis. In: Immunology of the Liver (Ed. by M. Smith and R. Williams), p. 194. Heinemann: London."},{"key":"ref_11","article-title":"Sicca Complex","volume":"340","author":"GOLDING, P.L.; BOWN, R.; MASON, A.M.S.; TAYLOR, E.","year":"1970","unstructured":"GOLDING, P.L., BOWN, R., MASON, A.M.S. & TAYLOR, E. (1970b) 'Sicca Complex' in liver disease. British Medical Journal, iv, 340.","journal-title":"in liver disease. British Medical Journal"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/gut.12.2.153","article-title":"Renal tubular acidosis and auto-immune liver disease","volume":"12","author":"GOLDING, P.L.; MASON, A.M.S.","year":"1971","unstructured":"GOLDING, P.L. & MASON, A.M.S. (1971) Renal tubular acidosis and auto-immune liver disease. Gut, 12, 153.","journal-title":"Gut"},{"key":"ref_13","first-page":"360","article-title":"Insuffisance progressive et atrophie des glandes salivaires et muqueuses de la bouche, des conjontives (et parois des muqueuses nasales, laryng6e, vulvaire), s6cheresse de la bouche, des conjonctives, etc","volume":"40","author":"GOUGEROT, H.","year":"1926","unstructured":"GOUGEROT, H. (1926) Insuffisance progressive et atrophie des glandes salivaires et muqueuses de la bouche, des conjontives (et parois des muqueuses nasales, laryng6e, vulvaire), s6cheresse de la bouche, des conjonctives, etc. Bulletin Medical (Paris), 40, 360.","journal-title":"Bulletin Medical (Paris)"},{"key":"ref_14","first-page":"185","article-title":"Intrahepatic cholestasis in two brothers","volume":"8","author":"KUHN, H.A.","year":"1963","unstructured":"KUHN, H.A. (1963) Intrahepatic cholestasis in two brothers. German Medicine Monthly, 8, 185.","journal-title":"German Medicine Monthly"},{"key":"ref_15","article-title":"Portal hypertension presenting with haemoperitoneum","volume":"544","author":"Ross, A.P.","year":"1970","unstructured":"Ross, A.P. (1970) Portal hypertension presenting with haemoperitoneum. British Medical Journal, i, 544.","journal-title":"British Medical Journal"},{"key":"ref_16","first-page":"22","article-title":"In: Liver Biopsy Interpretation","author":"SCHEUER, P.J.","year":"1968","unstructured":"SCHEUER, P.J. (1968) In: Liver Biopsy Interpretation, p. 22."},{"key":"ref_17","first-page":"173","article-title":"Idiopathic recurrent hyperbilirubinaemia","volume":"7","author":"SCHEUER, P.J.; WILLIAMS, R.; HILL, K.R.; SHERLOCK, S.","year":"1964","unstructured":"SCHEUER, P.J., WILLIAMS, R., HILL, K.R. & SHERLOCK, S. (1964) Idiopathic recurrent hyperbilirubinaemia. Tijdschrift voor Gastro-enterologie, 7b, 173.","journal-title":"Tijdschrift voor Gastro-enterologie"},{"key":"ref_18","article-title":"Chronic liver disease and mitochondrial antibodies: a family study","volume":"146","author":"WALKER, J.G.; BATES, D.; DONIACH, D.; BALL, P.A.J.; SHERLOCK, S.","year":"1972","unstructured":"WALKER, J.G., BATES, D., DONIACH, D., BALL, P.A.J. & SHERLOCK, S. (1972) Chronic liver disease and mitochondrial antibodies: a family study. British Medical Journal, i, 146.","journal-title":"British Medical Journal"},{"key":"ref_19","first-page":"115","article-title":"Postgraduate Medical Journal","volume":"51","year":"1975","unstructured":"Postgraduate Medical Journal (February 1975) 51, 115-116."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/51\/592\/110\/50257621\/postgradmedj-51-110.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/51\/592\/110\/50257621\/postgradmedj-51-110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T11:03:16Z","timestamp":1684234996000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/51\/592\/110\/7064104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,2,1]]},"references-count":19,"journal-issue":{"issue":"592","published-online":{"date-parts":[[1975,2,1]]},"published-print":{"date-parts":[[1975,2,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.51.592.110","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1975,2]]},"published":{"date-parts":[[1975,2,1]]}}}