{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:46:16Z","timestamp":1792147576653,"version":"4.4.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"596","license":[{"start":{"date-parts":[[1975,6,1]],"date-time":"1975-06-01T00:00:00Z","timestamp":170812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A patient with secondary syphilis presenting with jaundice is reported. Hepatic histology showed evidence of non-specific granuloma and active hepatitis but no cholestasis. This has been treated successfully with antisyphilitic therapy. The possibility of syphilitic pancreatitis and diabetes mellitus is discussed. The importance of serological tests for syphilis in jaundice of obscure origin is emphasized.<\/jats:p>","DOI":"10.1136\/pgmj.51.596.412","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"412-416","source":"Crossref","is-referenced-by-count":14,"title":["Secondary syphilis presenting with jaundice"],"prefix":"10.1093","volume":"51","author":[{"given":"B K","family":"Bhowmick","sequence":"first","affiliation":[{"name":"Department of Medicine, Burton Road Hospital , Dudley, Worcestershire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Burton Road Hospital , Dudley, Worcestershire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S P B","family":"Way","sequence":"additional","affiliation":[{"name":"Department of Pathology , Dudley, Stourbridge and District H.M.C"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1975,6,1]]},"reference":[{"key":"ref_1","article-title":"Control Problem. Joint statement of the","author":"D, Today's V.","year":"1970","unstructured":"AMERICAN SOCIAL HEALTH AssocIATION (1970) Today's V.D. Control Problem. Joint statement of the American Public Health Association, American Social Health Association, American Venereal Disease Association, New York."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJM197106242842507","article-title":"Liver disease associated with early syphilis","volume":"284","author":"BAKER, A.L.; KAPLAN, M.M.; WOLFE, H.J.; McGOWAN, J.A.","year":"1971","unstructured":"BAKER, A.L., KAPLAN, M.M., WOLFE, H.J. & McGOWAN, J.A. (1971) Liver disease associated with early syphilis. New England Journal of Medicine, 284, 1422.","journal-title":"New England Journal of Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0016-5085(67)80013-1","article-title":"Hepatic lesion in chronic inflammatory bowel disease","volume":"52","author":"DORDAL, E.; GLAGOV, S.; KIRSNER, J.B.","year":"1967","unstructured":"DORDAL, E., GLAGOV, S. & KIRSNER, J.B. (1967) Hepatic lesion in chronic inflammatory bowel disease. Gastroenterology, 52, 239.","journal-title":"Gastroenterology"},{"key":"ref_4","first-page":"529","article-title":"Syphilis of the liver","volume":"27","author":"HAHN, R.D.","year":"1943","unstructured":"HAHN, R.D. (1943) Syphilis of the liver. American Journal of Syphilis and Neurology, 27, 529.","journal-title":"American Journal of Syphilis and Neurology"},{"key":"ref_5","first-page":"207","article-title":"Hepatic manifestations of sarcoidosis and other granulomatous diseases: a study based on histological examination of tissue obtained by needle biopsy of the liver","volume":"23","author":"KLATSKIN, G.; YESNER, R.","year":"1950","unstructured":"KLATSKIN, G. & YESNER, R. (1950) Hepatic manifestations of sarcoidosis and other granulomatous diseases: a study based on histological examination of tissue obtained by needle biopsy of the liver. Yale Journal of Biology and Medicine, 23, 207.","journal-title":"Yale Journal of Biology and Medicine"},{"key":"ref_6","article-title":"Puzzling cases of secondary syphilis","volume":"66","author":"ARTICLE, L.E.A.D.I.N.G.","year":"1972","unstructured":"LEADING ARTICLE (1972) Puzzling cases of secondary syphilis. British Medical Journal, iii, 66.","journal-title":"British Medical Journal"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1056\/NEJM197106242842508","article-title":"Liver disease associated with secondary syphilis","volume":"284","author":"LEE, R.V.; THORNTON, G.F.; CoNN, H.O.","year":"1971","unstructured":"LEE, R.V., THORNTON, G.F. & CoNN, H.O. (1971) Liver disease associated with secondary syphilis. New England Journal of Medicine, 284, 1423.","journal-title":"New England Journal of Medicine"},{"key":"ref_8","first-page":"876","article-title":"Diseases of the Liver, Gall-bladder and Bile ducts","author":"LICHTMAN, S.S.","year":"1953","unstructured":"LICHTMAN, S.S. (1953) Diseases of the Liver, Gall-bladder and Bile ducts, 2nd edn, p. 876. Henry Kimpton, London.","edition":"2nd edn"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1093\/milmed\/134.9.682","article-title":"Nephrotic syndrome and hepatitis in secondary syphilis","volume":"134","author":"MCCRACKEN, J.D.; HALL, W.H.; PIERCE, H.I.","year":"1969","unstructured":"MCCRACKEN, J.D., HALL, W.H. & PIERCE, H.I. (1969) Nephrotic syndrome and hepatitis in secondary syphilis. Military Medicine, 134, 682.","journal-title":"Military Medicine"},{"key":"ref_10","article-title":"Archives of Internal Medicine, 66, 1011. Quoted in Joslin's Diabetes Mellitu3","author":"McDANIEL, L.T.; MARKS, H.H.; JOSLIN, E.P.","year":"1940","unstructured":"McDANIEL, L.T., MARKS, H.H. & JOSLIN, E.P. (1940) Archives of Internal Medicine, 66, 1011. Quoted in Joslin's Diabetes Mellitu3. (Ed. by Alexand-r Marble.) 11th edn. Lea and Sebiger (1971), Philadelphia.","edition":"11th edn","journal-title":"Lea and Sebiger"},{"key":"ref_11","first-page":"32","article-title":"Uncommon complications of early syphilis","volume":"48","author":"PARKER, J.D.J.","year":"1972","unstructured":"PARKER, J.D.J. (1972) Uncommon complications of early syphilis. British Journal of Venereal Diseases, 48, 32.","journal-title":"British Journal of Venereal Diseases"},{"key":"ref_12","first-page":"83","article-title":"Early syphilitic hepatitis","volume":"20","author":"RAJAM, R.V.; RANGIAH, P.N.","year":"1954","unstructured":"RAJAM, R.V. & RANGIAH, P.N. (1954) Early syphilitic hepatitis. Indian Journal of Venereal Diseases, 20, 83.","journal-title":"Indian Journal of Venereal Diseases"},{"key":"ref_13","first-page":"698","article-title":"Diseases of the Liver","author":"SCHIFF, L.","year":"1963","unstructured":"SCHIFF, L. (1963) Diseases of the Liver, 2nd edn, p. 698. Lippin Co. H., Philadelphia.","edition":"2nd edn"},{"key":"ref_14","article-title":"The liver in secondary (early) syphilis","author":"SHERLOCK, S.","year":"1971","unstructured":"SHERLOCK, S. (1971a) The liver in secondary (early) syphilis."},{"key":"ref_15","first-page":"1437","article-title":"New England","volume":"284","unstructured":"New England Journal of Medicine, 284, 1437.","journal-title":"Journal of Medicine"},{"key":"ref_16","first-page":"620","article-title":"Diseases ofthe Liver and Biliary System","volume-title":"Modern Clinical Syphilology","author":"SHERLOCK, S.","year":"1971","unstructured":"SHERLOCK, S. (1971b) Diseases ofthe Liver and Biliary System, 4th edn,. p. 620. Blackwell Scientific Publications, Oxford. STOKES, W.C., BEERMAN, C.E. & INGRAHAM, E. (1944) Modern Clinical Syphilology, 3rd edn., p. 109. W. B. Saunders Co., Philadelphia.","edition":"4th edn,"},{"key":"ref_17","first-page":"425","article-title":"The new pathology of syphilis","volume":"2","author":"WARTHIN, A.S.","year":"1918","unstructured":"WARTHIN, A.S. (1918) The new pathology of syphilis. American Journal of Syphilis and Neurology, 2, 425.","journal-title":"American Journal of Syphilis and Neurology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1001\/jama.1917.04270050013005","article-title":"Icterus gravis syphilitics: its relation to acute yellow atrophy","volume":"68","author":"WILE, U.J.; KARSHNER, R.G.","year":"1917","unstructured":"WILE, U.J. & KARSHNER, R.G. (1917) Icterus gravis syphilitics: its relation to acute yellow atrophy Journal of the American Medical Association, 68, 1311.","journal-title":"Journal of the American Medical Association"},{"key":"ref_19","first-page":"416","article-title":"Postgraduate Medical Journal","volume":"51","year":"1975","unstructured":"Postgraduate Medical Journal (June 1975) 51, 416-419."},{"key":"ref_20","article-title":"The syndrome of water diarrhoea, hypokalaemia and achlorhydria (WDHA) is well described in association with a non-beta islet cell tumour of the pancreas. The following case report is of a 28-year-old woman with a WDHA syndrome that was cured by the removal of a phaeochromocytoma","unstructured":"The syndrome of water diarrhoea, hypokalaemia and achlorhydria (WDHA) is well described in association with a non-beta islet cell tumour of the pancreas. The following case report is of a 28-year-old woman with a WDHA syndrome that was cured by the removal of a phaeochromocytoma."},{"key":"ref_21","article-title":"A 28-year-old-woman presented in 1968 with a 1year history of watery diarrhoea unassociated with blood or mucus. Examination, sigmoidoscopy and barium enema were unremarkable, and a diagnosis of mild ulcerative colitis was made. She was treated with anti-diarrhoeals and a milk-free diet. Her symptoms continued and the addition of salazopyrin, 1 g q.d.s. and prednisolone, 15 mg daily produced little improvement. Shortly after this she complained of paroxysmal headaches with preceding palpitations","unstructured":"A 28-year-old-woman presented in 1968 with a 1year history of watery diarrhoea unassociated with blood or mucus. Examination, sigmoidoscopy and barium enema were unremarkable, and a diagnosis of mild ulcerative colitis was made. She was treated with anti-diarrhoeals and a milk-free diet. Her symptoms continued and the addition of salazopyrin, 1 g q.d.s. and prednisolone, 15 mg daily produced little improvement. Shortly after this she complained of paroxysmal headaches with preceding palpitations"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/51\/596\/412\/50257667\/postgradmedj-51-412.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/51\/596\/412\/50257667\/postgradmedj-51-412.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T10:58:14Z","timestamp":1684234694000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/51\/596\/412\/7064185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,6,1]]},"references-count":21,"journal-issue":{"issue":"596","published-online":{"date-parts":[[1975,6,1]]},"published-print":{"date-parts":[[1975,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.51.596.412","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1975,6]]},"published":{"date-parts":[[1975,6,1]]}}}