{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:40:26Z","timestamp":1785404426923,"version":"3.56.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"596","license":[{"start":{"date-parts":[[1975,6,1]],"date-time":"1975-06-01T00:00:00Z","timestamp":170812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The syndrome of water diarrhoea, hypokalaemia and achlorhydria (WDHA) is well described in association with a non-beta islet cell tumour of the pancreas. The following case report is of a 28-year-old woman with a WDHA syndrome that was cured by the removal of a phaeochromocytoma.<\/jats:p>","DOI":"10.1136\/pgmj.51.596.416","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"416-419","source":"Crossref","is-referenced-by-count":23,"title":["Watery diarrhoea and hypokalaemia associated with a phaeochromocytoma"],"prefix":"10.1093","volume":"51","author":[{"given":"C A","family":"Loehry","sequence":"first","affiliation":[{"name":"Department of Medicine, Royal Victoria Hospital , Bournemouth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J G C","family":"Kingham","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Victoria Hospital , Bournemouth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Whorwell","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Victoria Hospital , Bournemouth"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1975,6,1]]},"reference":[{"key":"ref_1","article-title":"Vasoactive intestinal peptide and watery diarrhoea syndrome","volume":"14","author":"BLOOM, S.R.; POLAK, J.U.L.I.A.M.; PEARCE, A.G.E.","year":"1973","unstructured":"BLOOM, S.R., POLAK, JULIA M. & PEARCE, A.G.E. (1973) Vasoactive intestinal peptide and watery diarrhoea syndrome. Lancet, ii, 14.","journal-title":"Lancet"},{"key":"ref_2","first-page":"867","article-title":"A gastric inhibitory polypeptide Il; the complete amino acid sequence","volume":"49","author":"BROWN, J.C.; DRYBURGH, J.R.","year":"1971","unstructured":"BROWN, J.C. & DRYBURGH, J.R. (1971) A gastric inhibitory polypeptide Il; the complete amino acid sequence. Canadian Journal of Medicine, 49, 867.","journal-title":"Canadian Journal of Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.7326\/0003-4819-59-2-194","article-title":"The mastocytosis syndrome; clinical and biocheiitical studies","volume":"59","author":"DEMIs, D.J.","year":"1963","unstructured":"DEMIs, D.J. (1963) The mastocytosis syndrome; clinical and biocheiitical studies. Annals of Internal Medicine, 59, 194.","journal-title":"Annals of Internal Medicine"},{"key":"ref_4","article-title":"Pancreatic cholera due to production of gastric inhibitory polypeptide","volume":"791","author":"ELIAS, E.; POLAK, J.; BLOOM, S.R.; PEARCE, A.G.E.; WELBOURNE, R.B.; BOOTH, C.C.; CUZIO, M.; BROWN, J.C.","year":"1972","unstructured":"ELIAS, E., POLAK, J., BLOOM, S.R., PEARCE, A.G.E., WELBOURNE, R.B., BOOTH, C.C., CUZIO, M. & BROWN, J.C. (1972) Pancreatic cholera due to production of gastric inhibitory polypeptide. Lancet, ii, 791.","journal-title":"Lancet"},{"key":"ref_5","article-title":"Nature of the gastric secretagogue in ZollingerEllison tumours","author":"GREGORY, R.A.; GROSMAN, M.I.; TRACEY, H.J.; BENTLEY, P.H.","year":"1967","unstructured":"GREGORY, R.A., GROSMAN, M.I., TRACEY, H.J. & BENTLEY, P.H. (1967) Nature of the gastric secretagogue in ZollingerEllison tumours. Lancet,;j, 543."},{"key":"ref_6","first-page":"1105","article-title":"Alpha-methyl-p-thyrosine in the management of phaeochromocytoma","volume":"ii,","author":"JONES, N.F.; WALKER, G.; RUTHVEN, C.R.J.; SANDLER, M.","year":"1968","unstructured":"JONES, N.F., WALKER, G., RUTHVEN, C.R.J. & SANDLER, M. (1968) Alpha-methyl-p-thyrosine in the management of phaeochromocytoma. Lancet, ii, 1105.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0002-9610(70)90028-0","article-title":"Recognition and management of the diarrheal syndrome caused by non-beta islet cell tumours of the pancreas","volume":"119","author":"KRAFT, A.R.; TOMPKINS, R.K.; ZOLLINGER, R.M.","year":"1970","unstructured":"KRAFT, A.R., TOMPKINS, R.K. & ZOLLINGER, R.M. (1970) Recognition and management of the diarrheal syndrome caused by non-beta islet cell tumours of the pancreas. American Journal of Surgery, 119, 163.","journal-title":"American Journal of Surgery"},{"key":"ref_8","article-title":"The endocrinologic manifestations of the carcinoid tumour. In: Textbook of Endocrinology","author":"MELMON, K.L.","year":"1968","unstructured":"MELMON, K.L. (1968) The endocrinologic manifestations of the carcinoid tumour. In: Textbook of Endocrinology (Ed. by R. H. Williams). W. B. Saunders, Co., Philadelphia, London, Toronto."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1054-3589(08)60656-0","article-title":"Pharmacologic and endocrine aspects of carcinoid syndrome","volume":"5","author":"OATES, J.A.; BUTLER, T.C.","year":"1967","unstructured":"OATES, J.A. & BUTLER, T.C. (1967) Pharmacologic and endocrine aspects of carcinoid syndrome. 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Gastroenterology, 62, 393.","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1136\/gut.13.7.501","article-title":"Two types of Zollinger-Ellison syndrome immunofluorescent cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states","volume":"13","author":"POLAK, J.M.; STAGG, B.; PEARCE, A.G.E.","year":"1972","unstructured":"POLAK, J.M., STAGG, B. & PEARCE, A.G.E. (1972) Two types of Zollinger-Ellison syndrome immunofluorescent cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states. Gut, 13, 501.","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/17.5.303","article-title":"The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the Apud Series and the embryologic, physiologic and pathologic implications of the concept","volume":"17","author":"PEARCE, A.G.E.","year":"1969","unstructured":"PEARCE, A.G.E. (1969) The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the Apud Series and the embryologic, physiologic and pathologic implications of the concept. Journal of Histochemistry and Cytochemistry, 17, 303.","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0022-3476(63)80332-7","article-title":"Diarrhea in a child with a catecholamine-secreting ganglioneuroma. 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Most reports quote lung and the breast as the primary site of malignancy although other sites including the stomach are not uncommon. The metastases, either single or multiple, may be the initial manifestations of the internal malignancy","unstructured":"Metastatic lesions to the skin from internal malignancies are rare and the incidence has been reported to vary from one to 2 7\u00b0\/ (Gates, 1937; Beerman, 1957). Most reports quote lung and the breast as the primary site of malignancy although other sites including the stomach are not uncommon. 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