{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T18:19:52Z","timestamp":1699726792384},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"597","license":[{"start":{"date-parts":[[1975,7,1]],"date-time":"1975-07-01T00:00:00Z","timestamp":173404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,7,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Eight patients with hypocalcaemia who presented with frank or latent tetany due to parathyroid insufficiency or nutritional osteomalacia were studied. Their serum calcium ranged from 6\u00b785 to 7\u00b77 mg\/100 ml (mean 7\u00b733\u00b10\u00b736 mg\/100 ml). In six of them, serum calcium after treatment varied from 8\u00b74 to 9\u00b72 mg\/100 ml. In ten healthy normal subjects the serum calcium levels were 9\u00b70-10\u00b72 mg\/100 ml (9\u00b750\u00b10\u00b747 mg\/100 ml). The blood glucose levels during a 3 hr oral GTT were significantly elevated during hypocalcaemia and returned to normal levels after treatment. Serum insulin levels were low at 60 and 120 min after the administration of glucose in hypocalcaemia but returned to normal once the serum calcium levels were above 8\u00b74 mg\/100 ml. The FFA levels were high during the low calcium state and reached normal levels after treatment. The above studies suggest that an optimal level of serum calcium is essential for glucose-induced insulin release.<\/jats:p>","DOI":"10.1136\/pgmj.51.597.471","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"471-475","source":"Crossref","is-referenced-by-count":9,"title":["Effect of hypocalcaemia on glucose tolerance, insulin release and free fatty acid levels in human subjects"],"prefix":"10.1093","volume":"51","author":[{"given":"S","family":"Bansal","sequence":"first","affiliation":[{"name":"Metabolism and Endocrinology Unit, Department of Medicine, Maulana Azad Medical College and Associated Irwin and G. B. Pant Hospitals , New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S N A","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Metabolism and Endocrinology Unit, Department of Medicine, Maulana Azad Medical College and Associated Irwin and G. B. Pant Hospitals , New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M B","family":"Rao","sequence":"additional","affiliation":[{"name":"Metabolism and Endocrinology Unit, Department of Medicine, Maulana Azad Medical College and Associated Irwin and G. B. Pant Hospitals , New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Vaishnava","sequence":"additional","affiliation":[{"name":"Metabolism and Endocrinology Unit, Department of Medicine, Maulana Azad Medical College and Associated Irwin and G. B. Pant Hospitals , New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1975,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/clinchem\/11.8.741","article-title":"Determination of free fatty acids in plasma by a calorimetric procedure. An appraisal of the method and comparison with the techniques","volume":"11","author":"ANASTALL, H.B.; TRUJILLO, J.M.","year":"1965","unstructured":"ANASTALL, H.B. & TRUJILLO, J.M. (1965) Determination of free fatty acids in plasma by a calorimetric procedure. An appraisal of the method and comparison with the techniques. Clinical Chemistry, 11, 741.","journal-title":"Clinical Chemistry"},{"key":"ref_2","article-title":"In: Microanalysis in Medical Biochemistry","volume-title":"Wooton","author":"ASATOOR, A.; KING, E.J.","year":"1964","unstructured":"ASATOOR, A. & KING, E.J. (1964) In: Microanalysis in Medical Biochemistry. (Ed. by E. J. King and I. D. P. Wooton), 4th edn. J. & A. Churchill, Ltd., London.","edition":"4th edn"},{"key":"ref_3","first-page":"380","article-title":"Abnormal glucose and insulin response to oral glucose during hypocalcaemia","volume":"19","author":"CARMITTA, F.D.; STONER, R.E.","year":"1970","unstructured":"CARMITTA, F.D. & STONER, R.E. (1970) Abnormal glucose and insulin response to oral glucose during hypocalcaemia. Diabetes, 19, 380.","journal-title":"Diabetes"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1210\/endo-83-3-572","article-title":"Dynamics of insulin secretion by the perfused rat pancreas","volume":"83","author":"CURRY, D.L.; BENNETT, L.L.; GRODSKY, G.M.","year":"1968","unstructured":"CURRY, D.L., BENNETT, L.L. & GRODSKY, G.M. (1968) Dynamics of insulin secretion by the perfused rat pancreas. Endocrinology, 83, 572.","journal-title":"Endocrinology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"910","DOI":"10.2337\/diab.15.12.910","article-title":"Cation requirements for insulin secretion in the isolated perfused pancreas","volume":"15","author":"GRODSKY, G.M.; BENNETT, L.L.","year":"1966","unstructured":"GRODSKY, G.M. & BENNETT, L.L. (1966) Cation requirements for insulin secretion in the isolated perfused pancreas. 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II Insulin release induced by amino and organic acids by hormonal peptides, by cationic alterations of medium and by other agents. Biochemica et biophysica acta, 174, 540.","journal-title":"acta"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3181\/00379727-129-33269","article-title":"Insulin: Evidence for inhibition of release in spontaneous hypocalcaemia","volume":"129","author":"LITTLEDIKE, E.T.; WITZEL, D.A.; WHIPP, S.C.","year":"1968","unstructured":"LITTLEDIKE, E.T., WITZEL, D.A. & WHIPP, S.C. (1968) Insulin: Evidence for inhibition of release in spontaneous hypocalcaemia. 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Diabetes, 20, 382.","journal-title":"Diabetes"},{"key":"ref_16","first-page":"475","volume":"51","author":"Journal, Postgraduate Medical","year":"1975","unstructured":"Postgraduate Medical Journal, (July 1975) 51, 475-477."},{"key":"ref_17","article-title":"in which a definite diagnosis cannot be made","year":"1969","unstructured":"in which a definite diagnosis cannot be made (Brain and Walton, 1969)."},{"key":"ref_18","article-title":"Although pneumonitis is probably the commonest clinical presentation of infection with M. Pneumoniae, it is known that the nervous system may also be involved","volume-title":"especially in men and in the young. Eighth cranial nerve involvement has been described in only two patients","author":"(Dishoeck,","year":"1956","unstructured":"Although pneumonitis is probably the commonest clinical presentation of infection with M. 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