{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T11:11:02Z","timestamp":1684235462031},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"598","license":[{"start":{"date-parts":[[1975,8,1]],"date-time":"1975-08-01T00:00:00Z","timestamp":176083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The author first reviews, on the basis of personal and literature data, the main changes in three major parameters of potassium metabolism: serum potassium; daily urinary output of potassium; exchangeable potassium (Ke) at the three stages of the course of liver cirrhosis. The action of K-sparing diuretics (spironolactone, triamterene, amiloride) on these parameters is analysed. Although the introduction of these diuretics in our therapeutic armamentarium has resulted in a major advance, i.e. the quasi-total elimination of iatrogenic hypokalaemia and hypokalaemia-induced portacaval encephalopathy in the cirrhotic, the limits of their action on K metabolism are underlined: they may moderately enhance urinary K output; following cessation of their administration, a \u2018rebound\u2019 in urinary K output may be noted. Finally, Ke may still continue to decrease during their administration, indicating an aggravation of the underlying disease. It was also found that a rise in serum K and\/or Ke during amiloride administration did not prevent the elevation of plasma renin activity usually induced by volume and\/or Na depletion.<\/jats:p>","DOI":"10.1136\/pgmj.51.598.545","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"545-548","source":"Crossref","is-referenced-by-count":4,"title":["Potassium metabolism and diuretics administration in liver cirrhosis"],"prefix":"10.1093","volume":"51","author":[{"given":"P","family":"Vesin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine , Villeneuve-St-Georges, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1975,8,1]]},"reference":[{"key":"ref_1","article-title":"Body and serum potassium in liver disease","author":"CASEY, T.H.; SUMMERSKILL, W.H.J.; ORVIS, A.L.","year":"1965","unstructured":"CASEY, T.H., SUMMERSKILL, W.H.J. & ORVIS, A.L. (1965) Body and serum potassium in liver disease."},{"key":"ref_2","first-page":"249","article-title":"Relationship to hepatic function and associated factors","volume":"48","author":"Journal of Laboratory and Clinical Medicine,","year":"1974","unstructured":"Relationship to hepatic function and associated factors. Gastroenterology, 48, 198. DLUHY, R.G., CAIN, J.P. & WILLIAMS, G.H. (1974) The influence of dietary potassium on the renin and aldosterone response to diuretic-induced volume depletion. Journal of Laboratory and Clinical Medicine, 83, 249.","journal-title":"Gastroenterology; The influence of dietary potassium on the renin and aldosterone response to diuretic-induced volume depletion"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/00005792-196645060-00011","article-title":"Relation of potassium depletion to renal ammonium metabolism and hepatic coma","volume":"45","author":"GABUZDA, G.J.; HALL, P.W.","year":"1966","unstructured":"GABUZDA, G.J. & HALL, P.W. (1966) Relation of potassium depletion to renal ammonium metabolism and hepatic coma. Medicine, 45, 481.","journal-title":"Medicine"},{"key":"ref_4","first-page":"183","article-title":"Effet de l'aldactone sur le stock potassique chez les cirrhotiques ascitiques. Annales de Meidecine Interne","volume":"121","author":"LEVY, V.G.; LASSALE, B.; CURSO, D.E.L.; A.; CAROLI, J.","year":"1970","unstructured":"LEVY, V.G., LASSALE, B., DEL CURSO, A. & CAROLI, J. (1970) Effet de l'aldactone sur le stock potassique chez les cirrhotiques ascitiques. Annales de Meidecine Interne. 121, 183."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1152\/ajplegacy.1971.221.4.1192","article-title":"Potassium transport across renal distal tubule during acid-base disturbances","volume":"221","author":"MALNIC, G.; AIRES, D.E.M.E.L.L.O.; GIEBISCH, G.","year":"1971","unstructured":"MALNIC, G., DE MELLO AIRES & GIEBISCH, G. (1971) Potassium transport across renal distal tubule during acid-base disturbances. American Journal of Physiology, 221, 1192.","journal-title":"American Journal of Physiology"},{"key":"ref_6","article-title":"Exchangeable potassium in wasting, amyotrophy, heart-disease and cirrhosis of the liver","volume":"681","author":"DEUXCHAISNES, N.A.G.A.N.T.D.E.; C., B.U.S.S.E.T.; R., C.O.L.L.E.T.; A., R.; MACH, R.S.","year":"1961","unstructured":"NAGANT DE DEUXCHAISNES, C., BUSSET, R., COLLET, R.A. & MACH, R.S. (1961) Exchangeable potassium in wasting, amyotrophy, heart-disease and cirrhosis of the liver. Lancet, i, 681.","journal-title":"Lancet"},{"key":"ref_7","first-page":"409","article-title":"Neuropsychiatric complications following chlorothiazide therapy in patients with hepatic cirrhosis: possible relation to hypokalaemia","volume":"18","author":"READ, A.E.; LAIDLAN, J.; HASLAM, R.M.; SHERLOCK, S.","year":"1959","unstructured":"READ, A.E., LAIDLAN, J., HASLAM, R.M. & SHERLOCK, S. (1959) Neuropsychiatric complications following chlorothiazide therapy in patients with hepatic cirrhosis: possible relation to hypokalaemia. Clinical Science, 18, 409.","journal-title":"Clinical Science"},{"key":"ref_8","article-title":"Amiloride and plasma potassium","volume":"516","author":"SURVEYOR, 1. & SAUNDERS, R. A","year":"1968","unstructured":"SURVEYOR, 1. & SAUNDERS, R.A. (1968) Amiloride and plasma potassium. Lancet, ii, 516.","journal-title":"Lancet"},{"key":"ref_9","first-page":"1377","article-title":"Etude des clearances de l'inuline et du PAH, du debit cardiaque","volume":"16","author":"TRAVERSO, H.D.; RAYNAUD, C.L.; BLANCHON, P.; ROBERTI, A.; VESIN, P.; VIGUIE, R.; KELLERSHOHN, C.","year":"1966","unstructured":"TRAVERSO, H.D., RAYNAUD, CL., BLANCHON, P., ROBERTI, A., VESIN, P., VIGUIE, R. & KELLERSHOHN, C. (1966) Etude des clearances de l'inuline et du PAH, du debit cardiaque, du Na et du K echangeables et des liquides extra-cellulaires au cours de l'evolution de la cirrhose du foie. Revue internationale d'Hepatologie, 16, 1377.","journal-title":"Revue internationale d'Hepatologie; echangeables et des liquides extra-cellulaires au cours de l'evolution de la cirrhose du foie"},{"key":"ref_10","first-page":"873","article-title":"Water, electrolyte and acid-base disorders in liver disease. In: Clinical Disorders of Fluid and Electrolyte Metabolism","author":"VESIN, P.","year":"1972","unstructured":"VESIN, P. (1972a) Water, electrolyte and acid-base disorders in liver disease. In: Clinical Disorders of Fluid and Electrolyte Metabolism (Ed. by M. H. Maxwell and C. R. Kleeman), p. 873. McGraw Hill, New York."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/S0140-6736(72)92327-6","article-title":"Potassium supplements and diuretics","volume":"ii,","author":"VESIN, P.","year":"1972","unstructured":"VESIN, P. (1972b) Potassium supplements and diuretics. Lancet, ii, 1262.","journal-title":"Lancet"},{"key":"ref_12","first-page":"21","article-title":"Exchangeable potassium and plasma renin in cirrhotic patients receiving a potassium-retaining diuretic (amiloride). Vth International Congress","volume":"99","author":"VESIN, P.; MEYER, P.H.; TROUPEL, S.; GUEDRY, E.L.; H., S.F.A.R.T.I.; M., R.E.N.A.U.L.T.; H.; VIGUIE, R.","year":"1972","unstructured":"VESIN, P., MEYER, PH., TROUPEL, S., EL GUEDRY, H., SFARTI, M., RENAULT, H. & VIGUIE, R. (1972) Exchangeable potassium and plasma renin in cirrhotic patients receiving a potassium-retaining diuretic (amiloride). Vth International Congress of Nephrology. VESIN, P., ROBERTI, A. & VIGUIE, R. (1969) Actions de I'amiloride (MK870) sur le m6tabolisme hydro-6lectrolytique du cirrhotique ascitique. Schweizerische Medizinische Wochenschrift, 99, 21.","journal-title":"Schweizerische Medizinische Wochenschrift; Actions de I'amiloride (MK870) sur le m6tabolisme hydro-6lectrolytique du cirrhotique ascitique"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/pgmj.51.598.489","article-title":"Functional renal failure (FRF) in cirrhosis of the liver and liver carcinoma","volume":"51","author":"VESIN, P.; TRAVERSO, H.","year":"1975","unstructured":"VESIN, P. & TRAVERSO, H. (1975) Functional renal failure (FRF) in cirrhosis of the liver and liver carcinoma. Postgraduate Medical Journal, 51, 489.","journal-title":"Postgraduate Medical Journal"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0016-5085(19)33642-X","article-title":"Amiloride (MK870). A new antikaluretic diuretic","volume":"59","author":"YAMADA, S.; REYNOLDS, T.B.","year":"1970","unstructured":"YAMADA, S. & REYNOLDS, T.B. (1970) Amiloride (MK870). A new antikaluretic diuretic. 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