{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:03:45Z","timestamp":1761512625501},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"599","license":[{"start":{"date-parts":[[1975,9,1]],"date-time":"1975-09-01T00:00:00Z","timestamp":178761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,9,1]]},"abstract":"<jats:p>The processes involved in the progress of scientific knowledge have fascinated philosophers, scientific workers and non-scientists. Kuhn (1970), in his interesting essay on the structure of scientific revolutions, sees the road which the growth of scientific knowledge follows, not marked by discoveries but by what he names paradigms, \u2018theories that gain their status because they are more successful than their competitors in solving a few problems \u2026\u2019 which are recognized as acute. Examples of paradigms in biology are, e.g. Berthold\u2019s conceptualization of endocrinology in 1849; Mendel\u2019s theory of inheritance; Medawar\u2019s concept of immunological tolerance, etc.<\/jats:p>","DOI":"10.1136\/pgmj.51.599.591","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"591-599","source":"Crossref","is-referenced-by-count":8,"title":["Endemic cretinism\u2014a continuous personal educational experience during 10 years"],"prefix":"10.1093","volume":"51","author":[{"given":"A","family":"Querido","sequence":"first","affiliation":[{"name":"University of Leiden , Holland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1975,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1172\/JCI105673","article-title":"Otic lesions and congenital hypothyroidism in the developing chick","volume":"46","author":"BARGMAN, G.J.; GARDNER, L.I.","year":"1967","unstructured":"BARGMAN, G.J. & GARDNER, L.I. (1967) Otic lesions and congenital hypothyroidism in the developing chick. Journal of Clinical Investigation, 46, 1828.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1210\/jcem-22-2-187","article-title":"Endemic goitre in the Uele region. III. Endemic cretinism","volume":"22","author":"BASTENIE, P.A.; ERMANS, A.M.; THYS, O.; BECKERS, C.; VANDENSHRIECK, H.G.; VISSCHER, D.E.; M.","year":"1962","unstructured":"BASTENIE, P.A., ERMANS, A.M., THYS, O., BECKERS, C., VANDENSHRIECK, H.G. & DE VISSCHER, M. (1962) Endemic goitre in the Uele region. III. Endemic cretinism. Journal of Clinical Endocrinology and Metabolism, 22, 187.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_3","article-title":"Methods for the Measurement of","volume":"10","author":"BIESHEUVEL, S.","year":"1969","unstructured":"BIESHEUVEL, S. (1969) Methods for the Measurement of Psychological Performance. I.B.P. Handbook no. 10. Blackwell Scientific Publications, Oxford and Edinburgh.","journal-title":"Handbook"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1210\/jcem-23-12-1203","article-title":"Endemic goitre in New Guinea: Iodine metabolism in goitrous and non-goitrous subjects","volume":"23","author":"CHOUFOER, J.C.; RHIJN, V.A.N.; M., K.A.S.S.E.N.A.A.R.; H., A.A.; QUERIDO, A.","year":"1963","unstructured":"CHOUFOER, J.C., VAN RHIJN, M., KASSENAAR, A.A.H. & QUERIDO, A. (1963) Endemic goitre in New Guinea: Iodine metabolism in goitrous and non-goitrous subjects. Journal of Clinical Endocrinology, 23, 1203.","journal-title":"Journal of Clinical Endocrinology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1210\/jcem-25-3-385","article-title":"Endemic goitre in Western New Guinea. II. 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Journal ofMedical Genetics, 10, 235.","journal-title":"Journal ofMedical Genetics"},{"key":"ref_7","article-title":"The Effect of Severe Iodine Deficiency. A Study on a Population in Central Java, Indonesia","author":"DJOKOMOELJANTO, R.R.J.","year":"1974","unstructured":"DJOKOMOELJANTO, R.R.J. (1974) The Effect of Severe Iodine Deficiency. A Study on a Population in Central Java, Indonesia. Thesis, University of Semarang."},{"key":"ref_8","first-page":"7","article-title":"Normal brain development in human","author":"DOBBING, J.","year":"1975","unstructured":"DOBBING, J. (1975) Normal brain development in human. In: Proceedings of the Symposium on Brain Development and Thyroid Deficiency (Ed. by A. Querido and D. F. Swaab), p. 7. 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Methuen and Co., London."},{"key":"ref_14","article-title":"The Biology of Mental Dejfct","author":"PENROSE, L.S.","year":"1963","unstructured":"PENROSE, L.S. (1963) The Biology of Mental Dejfct. Sidgwick and Jackson, London."},{"key":"ref_15","article-title":"Endemic Goitre (Report meeting of the PAHO scientific group on research in endemic goitre)","volume":"193","author":"STANBURY, J.B.","year":"1969","unstructured":"STANBURY, J.B. (Ed.) (1969) Endemic Goitre (Report meeting of the PAHO scientific group on research in endemic goitre). WHO\/PAHO Scientific Publication No. 193. Washington D.C.","journal-title":"WHO\/PAHO Scientific Publication"},{"key":"ref_16","article-title":"Human Development and the Thyroid Gland: Relation to Endemic Cretinism","author":"STANBURY, J.B.; KROC, R.L.","year":"1972","unstructured":"STANBURY, J.B. & KROC, R.L. (Eds.) (1972) Human Development and the Thyroid Gland: Relation to Endemic Cretinism. 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