{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T11:10:28Z","timestamp":1684235428055},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"599","license":[{"start":{"date-parts":[[1975,9,1]],"date-time":"1975-09-01T00:00:00Z","timestamp":178761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The presumptive diagnosis of constitutional delayed adolescence is difficult to substantiate. Clinical examination and routine biochemical testing are not sufficient to exclude isolated gonadotrophin deficiency. Seven males are reported who presented with delayed puberty. These patients were given 100 \u03bcg luteinizing hormone-releasing hormone (LH-RH) intravenously, and the luteinizing hormone (LH) and follicle stimulating hormone (FSH) responses were measured.<\/jats:p>\n               <jats:p>Three of four males who were completely prepubertal (Stage 1) had a normal adult male response. These three patients have progressed further into puberty several months after this diagnostic test. The fourth patient in stage 1 puberty had a prepubertal LH response. A year later the response became adult in type, and 3 months thereafter stage 2 puberty was evident.<\/jats:p>\n               <jats:p>The LH response to LH-RH thus appears to have some prognostic value in the assessment of males presenting with delayed puberty.<\/jats:p>","DOI":"10.1136\/pgmj.51.599.611","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"611-614","source":"Crossref","is-referenced-by-count":0,"title":["The role of luteinizing hormone-releasing hormone in the diagnosis of constitutional delayed puberty"],"prefix":"10.1093","volume":"51","author":[{"given":"Julius","family":"Sagel","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Departments of Medicine and Radioisotopes, University of the Witwatersrand and Johannesburg General Hospital , Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry A","family":"Distiller","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Departments of Medicine and Radioisotopes, University of the Witwatersrand and Johannesburg General Hospital , Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry I","family":"Joffe","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Departments of Medicine and Radioisotopes, University of the Witwatersrand and Johannesburg General Hospital , Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1975,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1172\/JCI107798","article-title":"Simultaneous augmented secretion of luteinizing hormone and testosterone during sleep","volume":"54","author":"BOYAR, R.M.; ROSENFIELD, R.S.; KAPLAN, S.; W., F.I.N.K.E.L.S.T.E.I.N.J.; ROFFWARG, H.P.; WEITZMAN, E.D.; HELLMAN, L.","year":"1974","unstructured":"BOYAR, R.M., ROSENFIELD, R.S., KAPLAN, S., FINKELSTEIN. J.W., ROFFWARG, H.P., WEITZMAN, E.D. & HELLMAN, L, (1974) Simultaneous augmented secretion of luteinizing hormone and testosterone during sleep. Journal of Clinical Investigation, 54, 609.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1203\/00006450-197001000-00003","article-title":"Hormonal changes in puberty. I. Correlation of serum luteinizing hormone and follicle stimulating hormone with stages of puberty, testicular size and bone age in normal boys","volume":"4","author":"BURR, I.M.; SIZONENKO, P.C.; KAPLAN, S.L.; GRUMBACH, M.M.","year":"1970","unstructured":"BURR, I.M., SIZONENKO, P.C., KAPLAN, S.L. & GRUMBACH, M.M. (1970) Hormonal changes in puberty. I. Correlation of serum luteinizing hormone and follicle stimulating hormone with stages of puberty, testicular size and bone age in normal boys. Pediatric Research, 4, 25.","journal-title":"Pediatric Research"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0022-3476(69)80200-3","article-title":"Serum luteinizing hormone by radioimmunoassay in normal children","volume":"74","author":"JOHANSON, A.J.; GUYDA, H.J.; LIGHT, C.; MIGEON, C.J.; BLIZZARD, R.M.","year":"1969","unstructured":"JOHANSON, A.J., GUYDA, H.J., LIGHT, C., MIGEON, C.J. & BLIZZARD, R.M. (1969) Serum luteinizing hormone by radioimmunoassay in normal children. Journal of Pediatrics, 74, 416.","journal-title":"Journal of Pediatrics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1210\/jcem-33-3-551","article-title":"Pubertal maturation of the gonadotrophin stimulatory response to clomiphene","volume":"33","author":"KULIN, H.E.; REITER, E.O.; BRIDSON, W.E.","year":"1971","unstructured":"KULIN, H.E., REITER, E.O. & BRIDSON, W.E. (1971) Pubertal maturation of the gonadotrophin stimulatory response to clomiphene. Case Report. Journal of Clinical Endocrinology and Metabolism, 33, 551.","journal-title":"Case Report. Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1203\/00006450-197203000-00004","article-title":"Gonadalhypothalamic interaction in prepubertal and pubertal man: Effect of clomiphene citrate on urinary follicle-stimulating hormone and luteinizing hormone and plasma testosterone","volume":"6","author":"KULIN, H.E.; GRUMBACH, M.M.; KAPLAN, S.J.","year":"1972","unstructured":"KULIN, H.E., GRUMBACH, M.M. & KAPLAN, S.J. (1972) Gonadalhypothalamic interaction in prepubertal and pubertal man: Effect of clomiphene citrate on urinary follicle-stimulating hormone and luteinizing hormone and plasma testosterone. Pediatric Research, 6, 162.","journal-title":"Pediatric Research"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/51\/599\/611\/50258014\/postgradmedj-51-611.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/51\/599\/611\/50258014\/postgradmedj-51-611.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T10:48:40Z","timestamp":1684234120000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/51\/599\/611\/7064414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,9,1]]},"references-count":5,"journal-issue":{"issue":"599","published-online":{"date-parts":[[1975,9,1]]},"published-print":{"date-parts":[[1975,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.51.599.611","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1975,9]]},"published":{"date-parts":[[1975,9,1]]}}}