{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:50:51Z","timestamp":1762505451672},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"607","license":[{"start":{"date-parts":[[1976,5,1]],"date-time":"1976-05-01T00:00:00Z","timestamp":199756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A case of phaeochromocytoma and thyrotoxicosis occurring in the same patient is described, in which the similarity between the signs and symptoms produced by the two conditions delayed full diagnosis until post mortem. The mechanisms involved in the production of these signs and symptoms are discussed.<\/jats:p>","DOI":"10.1136\/pgmj.52.607.288","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"288-291","source":"Crossref","is-referenced-by-count":6,"title":["A case of associated thyrotoxicosis and phaeochromocytoma. A diagnostic problem"],"prefix":"10.1093","volume":"52","author":[{"given":"M H","family":"Snow","sequence":"first","affiliation":[{"name":"Newcastle General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Burton","sequence":"additional","affiliation":[{"name":"Newcastle General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1976,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1172\/JCI105658","article-title":"Influence of the thyroid state on the intrinsic contractile properties and energy stores of the myocardium","volume":"46","author":"BUCCINO, R.A.; SPANN, J.F.; POOL, P.E.; SONNENBLICK, E.H.; BRAUNWALD, E.","year":"1967","unstructured":"BUCCINO, R.A., SPANN, J.F., POOL, P.E., SONNENBLICK, E.H. & BRAUNWALD, E. (1967) Influence of the thyroid state on the intrinsic contractile properties and energy stores of the myocardium. Journal of Clinical Investigation, 46, 1669.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_2","first-page":"211","article-title":"Statistical methods applied to the clinical diagnosis of thyrotoxicosis","volume":"28","author":"CROOKS, J.; MURRAY, I.P.C.; WAYNE, E.J.","year":"1959","unstructured":"CROOKS, J., MURRAY, I.P.C. & WAYNE, E.J. (1959) Statistical methods applied to the clinical diagnosis of thyrotoxicosis. Quarterly Journal of Medicine, 28, 211.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1056\/NEJM196404232701702","article-title":"Elevated plasma free fatty acid concentrations in patients with phaeochromocytoma","volume":"270","author":"ENGLEMAN, K.; MUELLER, P.S.; SJOERDSMA, A.","year":"1964","unstructured":"ENGLEMAN, K., MUELLER, P.S. & SJOERDSMA, A. (1964) Elevated plasma free fatty acid concentrations in patients with phaeochromocytoma. New England Journal of Medicine, 270, 865.","journal-title":"New England Journal of Medicine"},{"key":"ref_4","first-page":"281","article-title":"Clinical features, diagnosis and treatment of phaeochromocytoma, a review of 76 cases","volume":"39","author":"GIFFORD, R.W.; KVALE, W.F.; MAHOR, T.T.; ROTH, G.M.; PRIESTLEY, J.T.","year":"1964","unstructured":"GIFFORD, R.W., KVALE, W.F., MAHOR, T.T., ROTH, G.M. & PRIESTLEY, J.T. (1964) Clinical features, diagnosis and treatment of phaeochromocytoma, a review of 76 cases. Proceedings. Mayo Clinic, 39, 281.","journal-title":"Proceedings. Mayo Clinic"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1152\/ajplegacy.1966.210.5.1053","article-title":"Role of thyroid hormones in lypolysis","volume":"210","author":"GOODMAN, H.M.; BRAY, G.A.","year":"1966","unstructured":"GOODMAN, H.M. & BRAY, G.A. (1966) Role of thyroid hormones in lypolysis. American Journal of Physiology, 210, 1053.","journal-title":"American Journal of Physiology"},{"key":"ref_6","first-page":"246","article-title":"Thyroidcatecholamine interaction. Studies on isolated brown fat cells","volume":"12","author":"HAMMOND, R.P.; HAMOLSKY, M.W.","year":"1969","unstructured":"HAMMOND, R.P. & HAMOLSKY, M.W. (1969) Thyroidcatecholamine interaction. Studies on isolated brown fat cells. Physiologist, 12, 246.","journal-title":"Physiologist"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1152\/physrev.1964.44.2.161","article-title":"Adrenal medullary and thyroid relationships","volume":"44","author":"HARRISON, T.S.","year":"1964","unstructured":"HARRISON, T.S. (1964) Adrenal medullary and thyroid relationships. Physiological Reviews, 44, 161.","journal-title":"Physiological Reviews"},{"key":"ref_8","article-title":"Human Tumours Secreting Catecholamines","author":"HERMAN, H.; MoNMEx, R.","year":"1964","unstructured":"HERMAN, H. & MoNMEx, R. (1964) Human Tumours Secreting Catecholamines. Pergamon Press, Oxford."},{"key":"ref_9","first-page":"628","article-title":"sympathetic blockade in hyperthyroidism","volume":"1","author":"Howirr, G.; ROWLANDS, D.J.","year":"1966","unstructured":"Howirr, G. & ROWLANDS, D.J. (1966) 13 sympathetic blockade in hyperthyroidism. Lancet, 1, 628.","journal-title":"Lancet"},{"key":"ref_10","first-page":"99","article-title":"Hormonal control of thermogenesis. Nonshivering thermogenesis","author":"LEBLANC, J.","year":"1970","unstructured":"LEBLANC, J. (1970) Hormonal control of thermogenesis. Nonshivering thermogenesis. Symposium, Prague, 1970, pp. 99. Academia, Prague."},{"key":"ref_11","first-page":"279","article-title":"Medullary thyroid carcinoma and phaeochromocytoma: a familial chromaffinomatosis","volume":"1","author":"LJUNDBERG, O.; CEDERQVIST, E.; STANDNITZ, W.","year":"1967","unstructured":"LJUNDBERG, O., CEDERQVIST, E. & STANDNITZ, W. VON (1967) Medullary thyroid carcinoma and phaeochromocytoma: a familial chromaffinomatosis. British Medical Journal, 1, 279.","journal-title":"VON"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1177\/003591576405700806","article-title":"Phaeochromocytoma presenting as postural hypotension","volume":"57","author":"PARKINSON, T.","year":"1964","unstructured":"PARKINSON, T. (1964) Phaeochromocytoma presenting as postural hypotension. Proceedings of the Royal Society of Medicine, 57, 673.","journal-title":"Proceedings of the Royal Society of Medicine"},{"key":"ref_13","article-title":"Controlled trial of propranolol in thyrotoxicosis","volume":"993","author":"SHANKS, R.G.; HADDEN, D.R.; LOWE, D.G.C.; MCDEVIrr, D.G.; MONTGOMERY, D.A.D.","year":"1969","unstructured":"SHANKS, R.G., HADDEN, D.R., LOWE, D.G.C., MCDEVIrr, D.G. & MONTGOMERY, D.A.D. (1969) Controlled trial of propranolol in thyrotoxicosis. Lancet, i, 993.","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/1097-0142(195909\/10)12:5<861::AID-CNCR2820120504>3.0.CO;2-6","article-title":"Histopathology of phaeochromocytoma","volume":"12","author":"SHERWIN, R.P.","year":"1959","unstructured":"SHERWIN, R.P. (1959) Histopathology of phaeochromocytoma. Cancer, 12, 861.","journal-title":"Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0002-9343(61)90234-0","article-title":"The association of phaeochromocytoma with carcinoma of the thyroid gland","volume":"31","author":"SIPPLE, J.H.","year":"1961","unstructured":"SIPPLE, J.H. (1961) The association of phaeochromocytoma with carcinoma of the thyroid gland. American Journal of Medicine, 31, 163.","journal-title":"American Journal of Medicine"},{"key":"ref_16","first-page":"1316","article-title":"Effect of adrenergic receptor blockade on the tachycardia of thyrotoxicosis and anxiety","volume":"ii,","author":"TUMER, P.; GRANVILLE-GROSSMAN, K.L.; SMART, J.V.","year":"1965","unstructured":"TUMER, P., GRANVILLE-GROSSMAN, K.L. & SMART, J.V. (1965) Effect of adrenergic receptor blockade on the tachycardia of thyrotoxicosis and anxiety. Lancet, ii, 1316.","journal-title":"Lancet"},{"key":"ref_17","first-page":"496","article-title":"The Thyroid","volume":"91","author":"WERNER, S.C.; INGBAR, S.H.","year":"1971","unstructured":"WERNER, S.C. & INGBAR, S.H. (1971) The Thyroid, 3rd Edition, p. 496. Harper and Rowe, New York. WILLIAMS, E.D. & POLLOCK, D.J. (1966) Multiple mucosal neuromata with endocrine tumours, a syndrome allied to von Reklinghausen's disease. Journal of Pathology and Bacteriology, 91, 71.","edition":"3","journal-title":"Journal of Pathology and Bacteriology; Multiple mucosal neuromata with endocrine tumours, a syndrome allied to von Reklinghausen's disease"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1210\/jcem-23-11-1102","article-title":"Urinary catecholamines and their metabolites in hyper and hypo-thyroidism","volume":"23","author":"WISWELL, J.G.; HURWITZ, G.C.; CORONHO, V.; BING, O.H.L.; CHILD, D.L.","year":"1963","unstructured":"WISWELL, J.G., HURWITZ, G.C., CORONHO, V., BING, O.H.L. & CHILD, D.L. (1963) Urinary catecholamines and their metabolites in hyper and hypo-thyroidism. Journal of Clinical Endocrinology, 23, 1102.","journal-title":"Journal of Clinical Endocrinology"},{"key":"ref_19","first-page":"377","article-title":"Current topics in thyroid research","author":"WOLLERBURGER, A.","year":"1965","unstructured":"WOLLERBURGER, A. (1965) Current topics in thyroid research (Ed. by D. C. Casson and M. Andreoli), p. 377. Academic Press, Inc., New York."},{"key":"ref_20","first-page":"291","article-title":"Postgraduate Medical Journal","volume":"52","year":"1976","unstructured":"Postgraduate Medical Journal (May 1976) 52, 291-292."},{"key":"ref_21","article-title":"A 25-year-old female was referred in 1973 with a history of ulceration of the left foot for 3 months, with severe pain at rest. Walking had become too painful to attempt. Pseudoxanthoma elasticum had been diagnosed at the age of 7 on the basis of classical skin changes. She had suffered from intermittent claudication in both calves for at least 10 years. A haematemesis had occurred in 1967. She became thyrotoxic in 1972 and was treated with carbimazole. On referral in 1973 she was euthyroid. Skin changes of pseudoxanthoma elasticum were present, particularly involving the sides of the neck. Angioid streaks were seen on fundoscopy. The lower limbs were wasted. The peripheral pulses were absent below the femorals. A painful ulcer, 3 x 2-5 cm, was present on the dorsum of the left foot, and a smaller","unstructured":"A 25-year-old female was referred in 1973 with a history of ulceration of the left foot for 3 months, with severe pain at rest. Walking had become too painful to attempt. Pseudoxanthoma elasticum had been diagnosed at the age of 7 on the basis of classical skin changes. She had suffered from intermittent claudication in both calves for at least 10 years. A haematemesis had occurred in 1967. She became thyrotoxic in 1972 and was treated with carbimazole. On referral in 1973 she was euthyroid. Skin changes of pseudoxanthoma elasticum were present, particularly involving the sides of the neck. Angioid streaks were seen on fundoscopy. The lower limbs were wasted. The peripheral pulses were absent below the femorals. A painful ulcer, 3 x 2-5 cm, was present on the dorsum of the left foot, and a smaller"},{"key":"ref_22","article-title":"Pseudoxanthoma elasticum is a genetically determined, probably autosomal recessive, disorder. A number of recent studies","year":"1958","unstructured":"Pseudoxanthoma elasticum is a genetically determined, probably autosomal recessive, disorder. A number of recent studies (Moran and Lansing, 1958;"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/607\/288\/50184676\/postgradmedj-52-288.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/607\/288\/50184676\/postgradmedj-52-288.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T12:47:29Z","timestamp":1683290849000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/52\/607\/288\/7038094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,5,1]]},"references-count":22,"journal-issue":{"issue":"607","published-online":{"date-parts":[[1976,5,1]]},"published-print":{"date-parts":[[1976,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.52.607.288","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1976,5]]},"published":{"date-parts":[[1976,5,1]]}}}