{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T22:44:59Z","timestamp":1777157099723,"version":"3.51.4"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"607","license":[{"start":{"date-parts":[[1976,5,1]],"date-time":"1976-05-01T00:00:00Z","timestamp":199756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Two patients with Hodgkin's disease and cryptococcal meningitis are described. Both patients were treated with a combination of the two antifungal agents, amphotericin B and flucytosine. Nephrotoxicity was easily reversible in both patients and clinical improvement was seen with this combination therapy. Intrathecal therapy with amphotericin B was used in both patients. The optimal treatment of this disease may prove to be a combination of oral flucytosine, with amphotericin B given by intrathecal injection as well as rapid low dose intravenous injection.<\/jats:p>","DOI":"10.1136\/pgmj.52.607.305","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"305-308","source":"Crossref","is-referenced-by-count":16,"title":["Combination antifungal therapy for cryptococcal meningitis"],"prefix":"10.1093","volume":"52","author":[{"given":"J S","family":"Tobias","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, St Bartholomew's Hospital , London EC1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P F M","family":"Wrigley","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, St Bartholomew's Hospital , London EC1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, St Bartholomew's Hospital , London EC1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1976,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3181\/00379727-142-37049","article-title":"The combined effect of 5-fluorocytosine and amphotericin-B on the therapy of murine cryptococcosis","volume":"142","author":"BLOCK, E.R.; BENNETT, J.E.","year":"1973","unstructured":"BLOCK, E.R. & BENNETT, J.E. 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