{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:21:28Z","timestamp":1758824488304},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"609","license":[{"start":{"date-parts":[[1976,7,1]],"date-time":"1976-07-01T00:00:00Z","timestamp":205027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,7,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Increased prevalence and incidence of arterial disease has become the major cause of disability and death in diabetics in Western cultures\u2014but is much less common among Japanese and African diabetics. In the West, the presence of lesser, \u2018subdiabetic\u2019 degrees of glucose intolerance are probably independent \u2018risk factors\u2019 for accelerated atherosclerosis. Although many explanations for the link have been advanced\u2014among them direct effects of glucose and insulin on the arterial wall, less direct effects of circulating lipoproteins, abnormalities of blood clotting and fibrinolysis and elevated blood pressure, even the influence of antidiabetic treatment itself\u2014none has been clearly established. Nevertheless there is scope and hope that appropriate measures may reduce the raised arterial disease risk in the diabetic.<\/jats:p>","DOI":"10.1136\/pgmj.52.609.445","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"445-451","source":"Crossref","is-referenced-by-count":18,"title":["Glucose intolerance, diabetes mellitus and atherosclerosis; prospects for prevention"],"prefix":"10.1093","volume":"52","author":[{"given":"Harry","family":"Keen","sequence":"first","affiliation":[{"name":"Unit for Metabolic Medicine, Diabetic Clinic, Guy's Hospital , London, S.E.1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1976,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1136\/bmj.1.5644.599","article-title":"Oral glucose tolerance and related factors in a normal population sample. II. 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