{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:10:15Z","timestamp":1709867415614},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"610","license":[{"start":{"date-parts":[[1976,8,1]],"date-time":"1976-08-01T00:00:00Z","timestamp":207705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,8,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Debrisoquine, guanethidine and bethanidine may produce troublesome hypotensive symtoms related to exertion. Thirteen patients with such symptoms were exercised on a treadmill and the response of blood pressure and heart rate was compared to that of thirty patients without these symptoms, who were exercised to the same extent. There was a slight drop of systolic and diastolic pressures on standing in both groups, but after exertion there was a significantly greater drop of systolic pressure in the group with symptoms than in the asymptomatic group. The diastolic pressure after exertion was significantly lower in the group with symptoms. It was impossible to predict from the standing blood pressure levels at rest which patients would develop hypotensive symptoms after exertion. All three drugs had a similar negative chronotropic effect at rest and on exercise. It is suggested that patients are exercised during control of hypertension in order to identify those prone to exertional hypotension. Patients with such hypotension should be exercised on each attendance before the blood pressure is measured. Treatment other than postganglionic sympathetic blocking drugs should be employed whenever possible in patients with milder hypertension.<\/jats:p>","DOI":"10.1136\/pgmj.52.610.487","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"487-491","source":"Crossref","is-referenced-by-count":2,"title":["Exertional hypotension due to postganglionic sympathetic blocking drugs"],"prefix":"10.1093","volume":"52","author":[{"given":"S","family":"Talbot","sequence":"first","affiliation":[{"name":"Sheffield Hypertension Clinic, Royal Infirmary , Sheffield S6 3DA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G W","family":"Gill","sequence":"additional","affiliation":[{"name":"Sheffield Hypertension Clinic, Royal Infirmary , Sheffield S6 3DA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1976,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/0002-8703(73)90502-4","article-title":"Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease","volume":"85","author":"BRUCE, R.A.; KusuMi, F.; HOSMER, D.","year":"1973","unstructured":"BRUCE, R.A., KusuMi, F. & HOSMER, D. (1973) Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. American Heart Journal, 85, 546.","journal-title":"American Heart Journal"},{"key":"ref_2","article-title":"Clinical and pharmacological studies with guanethidine in the treatment of hypertension","volume":"381","author":"DOLLERY, C.T.; EMSLIE-SMITH, D.; MILNE, M.D.","year":"1960","unstructured":"DOLLERY, C.T., EMSLIE-SMITH, D. & MILNE, M.D. (1960) Clinical and pharmacological studies with guanethidine in the treatment of hypertension. Lancet, ii, 381.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/hrt.35.4.413","article-title":"Static exercises in untreated systemic hypertension","volume":"35","author":"EWING, D.J.; IRVING, J.B.; KERR, F.; KIRBY, B.J.","year":"1973","unstructured":"EWING, D.J., IRVING, J.B., KERR, F. & KIRBY, B.J. (1973) Static exercises in untreated systemic hypertension. British Heart Journal, 35, 413.","journal-title":"British Heart Journal"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1161\/01.RES.10.1.83","article-title":"Analysis of the acute circulatory effects of guanethidine and Bredyllium","volume":"10","author":"GAFFNEY, T.E.; BRAUNWALD, E.; COOPER, T.","year":"1962","unstructured":"GAFFNEY, T.E., BRAUNWALD, E. & COOPER, T. (1962) Analysis of the acute circulatory effects of guanethidine and Bredyllium. Circulation Research, 10, 83.","journal-title":"Circulation Research"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.0954-6820.1970.tb08074.x","article-title":"Haemodynamic responses to sustained handgrip in patients with hypertension","volume":"188","author":"HOEL, B.L.; LORENTSEN, E.; LUND-LARSEN, P.G.","year":"1970","unstructured":"HOEL, B.L., LORENTSEN, E. & LUND-LARSEN, P.G. (1970) Haemodynamic responses to sustained handgrip in patients with hypertension. 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