{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T09:47:55Z","timestamp":1768988875741,"version":"3.49.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"610","license":[{"start":{"date-parts":[[1976,8,1]],"date-time":"1976-08-01T00:00:00Z","timestamp":207705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A double-blind, placebo-controlled, cross-over clinical trial was performed to assess the effect of betahistine hydrochloride (Serc) in M\u00e9ni\u00e8re's disease. The diagnosis was based on paroxysmal attacks of rotational vertigo, with tinnitus, and a fluctuating sensori-neural deafness, together with the results of auditory and vestigular tests. Twenty-eight patients were admitted to the trial over 3 years. Twenty-two patients completed the trial. In total, they received betahistine 32 mg daily, for a period of 16 weeks, and placebo also for the same length of time, preceded in every case by a 4-week pre-treatment period. Daily symptom score cards were kept. There was a statistically significant improvement in favour of the drug with regard to vertigo, tinnitus and deafness. Vertigo was the most responsive symptom. No adverse reactions were observed.<\/jats:p>","DOI":"10.1136\/pgmj.52.610.501","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"501-503","source":"Crossref","is-referenced-by-count":38,"title":["Betahistine hydrochloride in M\u00e9ni\u00e9re's disease"],"prefix":"10.1093","volume":"52","author":[{"given":"I J C","family":"Frew","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Newcastle University Hospitals Group"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G N","family":"Menon","sequence":"additional","affiliation":[{"name":"Philips-Duphar B. V. , Weesp, Holland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1976,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1288\/00005537-197106000-00009","article-title":"Modification of the vestibular function with betahistine HCl","volume":"81","author":"BERTRAND, R.A.","year":"1971","unstructured":"BERTRAND, R.A. (1971) Modification of the vestibular function with betahistine HCl. Laryngoscope, 81, 889.","journal-title":"Laryngoscope"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1001\/jama.1966.03100150133043","article-title":"Double-blind evaluation of a new treatment for MWniere's syndrome","volume":"196","author":"ELIA, J.C.","year":"1966","unstructured":"ELIA, J.C. (1966) Double-blind evaluation of a new treatment for MWniere's syndrome. Journal of the American Medical Association, 196, 187.","journal-title":"Journal of the American Medical Association"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1001\/archotol.1967.00760050612003","article-title":"Meniere s disease","volume":"86","author":"HICKS, J.J.; HICKS, J.N.; COOLEY, H.N.","year":"1967","unstructured":"HICKS, J.J., HICKS, J.N. & COOLEY, H.N. (1967) Meniere s disease. Archives of Otolaryngology, Chicago, 86, 610.","journal-title":"Archives of Otolaryngology, Chicago"},{"issue":"10","key":"ref_4","article-title":"Review of treatment of MWniere's syndrome","volume":"305","author":"HINCHCLIFFE, R.","year":"1972","unstructured":"HINCHCLIFFE, R. (1972) Review of treatment of MWniere's syndrome. Acta otolaryngologica (Suppl.), 305, 10.","journal-title":"Acta otolaryngologica (Suppl.)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3109\/00016487209122699","article-title":"A study of the efficacy of betahistine in MWniere's syndrome","volume":"305","author":"HOMMEs, 0","year":"1972","unstructured":"HOMMEs, 0. (1972) A study of the efficacy of betahistine in MWniere's syndrome. Acta otolaryngologica (Suppl.), 305, 70.","journal-title":"Acta otolaryngologica (Suppl.)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/00016487209122697","article-title":"The effect of Serc (betahistine hydrochloride) on the circulation of the inner ear in experimental animals","volume":"305","author":"MARTINEZ, D.M.","year":"1972","unstructured":"MARTINEZ, D.M. (1972) The effect of Serc (betahistine hydrochloride) on the circulation of the inner ear in experimental animals. Acta otolaryngologica (Suppl.), 305, 29.","journal-title":"Acta otolaryngologica (Suppl.)"},{"key":"ref_7","article-title":"Personal Communication","author":"SEYMOUR, J.","year":"1951","unstructured":"SEYMOUR, J. (1951) Personal Communication."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/610\/501\/50185051\/postgradmedj-52-501.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/610\/501\/50185051\/postgradmedj-52-501.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T06:37:21Z","timestamp":1683527841000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/52\/610\/501\/7037981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,8,1]]},"references-count":7,"journal-issue":{"issue":"610","published-online":{"date-parts":[[1976,8,1]]},"published-print":{"date-parts":[[1976,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.52.610.501","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1976,8]]},"published":{"date-parts":[[1976,8,1]]}}}