{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T06:40:26Z","timestamp":1684824026044},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"610","license":[{"start":{"date-parts":[[1976,8,1]],"date-time":"1976-08-01T00:00:00Z","timestamp":207705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,8,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The treatment of a 12-year-old girl with a lifelone history of recurrent infections and aphthous stomatitis is reported. A profound neutropenis, first noted at the age of 2 years, occurring at least every month was observed together with multiple mouth ulcers a sore throat and swelling of the jugular glands. Levamisole, originally described as an anthelmintic, has a beneficial effect on the symptoms of recurrent aphthous stomatitis. After levamisole treatment aphthous stomatitis was milder and in the 1-year follow-up period the patient was asymptomatic several times during a phase of obvious neutrophil depression. The child no longer complained of a sore throat with swelling of the jugular glands and the recurrent staphylococcal infections of the skin disappeared. After therapy a marked increase in monocytes at the moment of neutropenia was observed.<\/jats:p>","DOI":"10.1136\/pgmj.52.610.511","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"511-514","source":"Crossref","is-referenced-by-count":3,"title":["Levamisole treatment of a child with severe aphthous stomatitis and neutropenia"],"prefix":"10.1093","volume":"52","author":[{"given":"H","family":"Verhaegen","sequence":"first","affiliation":[{"name":"Clinical Research Unit, St Bartholomeus Hospital, B-2060 Merksem (Antwerp) , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"De Cr\u00e9e","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, St Bartholomeus Hospital, B-2060 Merksem (Antwerp) , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"De Cock","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, St Bartholomeus Hospital, B-2060 Merksem (Antwerp) , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Brugmans","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, St Bartholomeus Hospital, B-2060 Merksem (Antwerp) , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1976,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/0024-3205(73)90137-9","article-title":"Restoration of host defense mechanisms in man by levamisole","volume":"13","author":"BRUGMANS, J.; SCHUERMANS, V.; COCK, D.E.; W., T.H.I.E.N.P.O.N.T.; D., J.A.N.S.S.E.N.; P., V.E.R.H.A.E.G.E.N.; H., V.A.N.N.I.M.M.E.N.; L., L.O.U.W.A.G.I.E.; C., A.; STEVENS, E.","year":"1973","unstructured":"BRUGMANS, J., SCHUERMANS, V., DE COCK, W., THIENPONT, D., JANSSEN, P., VERHAEGEN, H., VAN NIMMEN, L., LOUWAGIE, A.C. & STEVENS, E. (1973) Restoration of host defense mechanisms in man by levamisole. Life Sciences, 13, 1499.","journal-title":"Life Sciences"},{"key":"ref_2","first-page":"482","article-title":"Neutropenie cyclique chez un enfant de 6 ans","volume":"3","author":"CANTEL, Y.; MAREL, H.; THANCET, G.","year":"1963","unstructured":"CANTEL, Y., MAREL, H. & THANCET, G. (1963) Neutropenie cyclique chez un enfant de 6 ans. Nouvelle Revue Franfaise d'Hgmatologie, 3, 482.","journal-title":"Nouvelle Revue Franfaise d'Hgmatologie"},{"key":"ref_3","first-page":"306","article-title":"The effect of levamisole on the immunologic response of HBAg positive patients","volume":"10","author":"DE, C.R.P.E.; J., V.E.R.H.A.E.G.E.N.; H., D.E.; COCK, W.; BRUGMANS, J.","year":"1974","unstructured":"DE CRPE, J., VERHAEGEN, H., DE COCK, W. & BRUGMANS, J. (1974a) The effect of levamisole on the immunologic response of HBAg positive patients. 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Journal of Clinical Investigations, 52, 568.","journal-title":"Journal of Clinical Investigations"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1172\/JCI107124","article-title":"Identification of the colony-stimulating cell in human peripheral blood","volume":"51","author":"GOLDE, D.W.; CLINE, M.J.","year":"1972","unstructured":"GOLDE, D.W. & CLINE, M.J. (1972) Identification of the colony-stimulating cell in human peripheral blood. Journal of Clinical Investigations, 51, 2981.","journal-title":"Journal of Clinical Investigations"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1172\/JCI107522","article-title":"Periodic hematopoiesis in human cyclic neutropenia","volume":"52","author":"GUERRY, D.; DALE, D.C.; AMINE, M.; PERRY, S.; WOLFF, S.M.","year":"1973","unstructured":"GUERRY, D., DALE, D.C., AMINE, M., PERRY, S. & WOLFF, S.M. (1973) Periodic hematopoiesis in human cyclic neutropenia. 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Experientia, 30, 945.","journal-title":"Experientia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1001\/archpedi.1957.04030070035006","article-title":"Studies in cyclic neutropenia. A clinical and experimental investigation","volume":"94","author":"PAYE, A.R.; GOOD, R.A.","year":"1957","unstructured":"PAYE, A.R. & GOOD, R.A. (1957) Studies in cyclic neutropenia. A clinical and experimental investigation. American Journal of Diseases of Children, 94, 623.","journal-title":"American Journal of Diseases of Children"},{"key":"ref_15","first-page":"349","article-title":"Effet immunostimulant d'un imidothiazole dans l'immunisation des souris contre l'infection par Brucella abortus. Compte rendu hgbdomadaire des se6ances de l'Acadjmie des Sciences","volume":"272","author":"RENOUX, G.; RENOUX, M.","year":"1971","unstructured":"RENOUX, G. & RENOUX, M. 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Nature, London, 209, 1084.","journal-title":"Nature, London; a new, potent broad spectrum anthelmintic"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1056\/NEJM197308162890707","article-title":"Druginduced restoration of cutaneous delayed hypersensitivity in anergic patients with cancer","volume":"289","author":"TRIPODI, D.; PARKS, L.C.; BRUGMANS, J.","year":"1973","unstructured":"TRIPODI, D., PARKS, L.C. & BRUGMANS, J. (1973) Druginduced restoration of cutaneous delayed hypersensitivity in anergic patients with cancer. New England Journal of Medicine, 289, 354.","journal-title":"New England Journal of Medicine"},{"key":"ref_19","article-title":"Effect of levamisole on contact angle and on phagocytosis by macrophages","author":"VAN, O.S.S.; J, C.","year":"1973","unstructured":"VAN OSS, C.J. (1973) Effect of levamisole on contact angle and on phagocytosis by macrophages. (Unpublished data.)"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0140-6736(73)90879-9","article-title":"Treatment of aphthous stomatitis","volume":"iH,","author":"VERHAEGEN, H.; CRka, D.E.; J.; BRUGMANS, J.","year":"1973","unstructured":"VERHAEGEN, H., DE CRka, J. & BRUGMANS, J. (1973a) Treatment of aphthous stomatitis. Lancet, iH, 842.","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJM197311222892121","article-title":"Levamisole and the immune response","volume":"289","author":"VERHAEGEN, H.; CRtE, D.E.; J., D.E.C.O.C.K.; W.; VERBRUGGEN, F.","year":"1973","unstructured":"VERHAEGEN, H., DE CRtE, J., DE COCK, W. & VERBRUGGEN, F. (1973b) Levamisole and the immune response. 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Acta medica scandinavica, 172, 715.","journal-title":"Acta medica scandinavica"},{"key":"ref_24","first-page":"514","article-title":"Postgraduate Medical Journal","volume":"52","year":"1976","unstructured":"Postgraduate Medical Journal (August 1976) 52, 514-517."},{"key":"ref_25","article-title":"North Manchester General Hospital Summary A case of carcinoid tumour of Vater's ampulla is described from a patient with widespread cutaneous neurofibromatosis. The literature concerning the few known cases of carcinoids occurring at this site is briefly reviewed and the presentation, prognosis and treatment discussed, together with the possible significance of such a clinical association","unstructured":"North Manchester General Hospital Summary A case of carcinoid tumour of Vater's ampulla is described from a patient with widespread cutaneous neurofibromatosis. The literature concerning the few known cases of carcinoids occurring at this site is briefly reviewed and the presentation, prognosis and treatment discussed, together with the possible significance of such a clinical association."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/610\/511\/50185136\/postgradmedj-52-511.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/610\/511\/50185136\/postgradmedj-52-511.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T06:21:20Z","timestamp":1684822880000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/52\/610\/511\/7037987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,8,1]]},"references-count":25,"journal-issue":{"issue":"610","published-online":{"date-parts":[[1976,8,1]]},"published-print":{"date-parts":[[1976,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.52.610.511","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1976,8]]},"published":{"date-parts":[[1976,8,1]]}}}