{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T07:10:43Z","timestamp":1683529843748},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"610","license":[{"start":{"date-parts":[[1976,8,1]],"date-time":"1976-08-01T00:00:00Z","timestamp":207705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Acute water intoxication with deepening coma and uncontrolled epileptiform seizures in a 25-year-old previously fit male schizophrenic was treated with hypertonic (2 N) saline and a 20% mannitol solution. This improved his neurological state but precipitated severe pulmonary oedema. Intravenous frusemide increased his urinary output sufficiently to clear the pulmonary oedema. In acute water intoxication the use of hypertonic solutions may thus precipitate left heart failure by expanding the intra-pulmonary blood volume beyond the capacity of even a healthy left ventricle to compensate. Simple water restriction will produce a slower but perhaps safer improvement.<\/jats:p>","DOI":"10.1136\/pgmj.52.610.532","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"532-535","source":"Crossref","is-referenced-by-count":4,"title":["Pulmonary oedema during treatment of acute water intoxication"],"prefix":"10.1093","volume":"52","author":[{"given":"D","family":"Maclean","sequence":"first","affiliation":[{"name":"University Department of Medicine and the Medical Professorial Unit, Ninewells Hospital and Medical School , Dundee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Champion","sequence":"additional","affiliation":[{"name":"University Department of Medicine and the Medical Professorial Unit, Ninewells Hospital and Medical School , Dundee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D B","family":"Trash","sequence":"additional","affiliation":[{"name":"University Department of Medicine and the Medical Professorial Unit, Ninewells Hospital and Medical School , Dundee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1976,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/bmj.1.5845.89","article-title":"Water intoxication in relation to acute psychotic disorder","volume":"1","author":"ALEXANDER, E.R.; CROW, T.J.; HAMILTON, S.M.","year":"1973","unstructured":"ALEXANDER, E.R., CROW, T.J. & HAMILTON, S.M. (1973) Water intoxication in relation to acute psychotic disorder. British Medical Journal, 1, 89.","journal-title":"British Medical Journal"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1136\/bmj.2.5413.864","article-title":"Acute water-intoxication from compulsive water-drinking","volume":"2","author":"BEWLEY, T.H.","year":"1964","unstructured":"BEWLEY, T.H. (1964) Acute water-intoxication from compulsive water-drinking. British Medical Journal, 2, 864.","journal-title":"British Medical Journal"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1001\/archsurg.1967.01330180050009","article-title":"Pitfalls in the clinical use of central venous pressure","volume":"95","author":"BRISMAN, R.; PARKS, L.C.; BENSON, D.W.","year":"1967","unstructured":"BRISMAN, R., PARKS, L.C. & BENSON, D.W. (1967) Pitfalls in the clinical use of central venous pressure. Archives of Surgery, 95, 902.","journal-title":"Archives of Surgery"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1056\/NEJM197107222850402","article-title":"Filling pressures in the right and left sides of the heart in acute myocardial infarction. A reappraisal of central-venous-pressure monitoring","volume":"285","author":"FORRESTER, J.S.; DIAMOND, G.; MCHUGH, T.J.; SWAN, H.J.C.","year":"1971","unstructured":"FORRESTER, J.S., DIAMOND, G., MCHUGH, T.J. & SWAN, H.J.C. (1971) Filling pressures in the right and left sides of the heart in acute myocardial infarction. A reappraisal of central-venous-pressure monitoring. New England Journal of Medicine, 285, 190.","journal-title":"New England Journal of Medicine"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1172\/JCI102805","article-title":"Evidence in man that urinary electrolyte loss induced by pitressinis a function of water retention","volume":"32","year":"1953","unstructured":"LEAF, A., BARTTER, F.C., SANTOS, R.F. & WRONG, 0. (1953) Evidence in man that urinary electrolyte loss induced by pitressinis a function of water retention. Journal of Clinical Investigation, 32, 868.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_6","first-page":"952","article-title":"The mechanism of the osmotic adjustment of the body cells","volume":"33","year":"1954","unstructured":"LEAF, A., CHATILLON, J.Y., WRONG, 0. & TUTTLE, E.P. (1954) The mechanism of the osmotic adjustment of the body cells. Journal of Clinical Investigation, 33, 952.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1152\/physrev.1922.2.1.116","article-title":"The water balance of the body","volume":"2","author":"ROWNTREE, L.G.","year":"1922","unstructured":"ROWNTREE, L.G. (1922) The water balance of the body. Physiological Reviews, 2, 116.","journal-title":"Physiological Reviews"},{"key":"ref_8","article-title":"Water intoxication. Differential diagnosis of the hypotonic syndromes","volume":"587","author":"WYNN, V.; ROB, C.G.","year":"1954","unstructured":"WYNN, V. & ROB, C.G. (1954) Water intoxication. Differential diagnosis of the hypotonic syndromes. Lancer, i, 587.","journal-title":"Lancer"},{"key":"ref_9","first-page":"375","article-title":"Observations in man upon the osmotic behaviour of the body cells after trauma","volume":"XXVI,","author":"WYNN, V.; HOUGHTON, B.J.","year":"1957","unstructured":"WYNN, V. & HOUGHTON, B.J. (1957) Observations in man upon the osmotic behaviour of the body cells after trauma. Quarterly Journal of Medicine. New Series, XXVI, 375.","journal-title":"Quarterly Journal of Medicine. New Series"},{"key":"ref_10","first-page":"535","article-title":"Postgraduate Medical Journal","volume":"52","year":"1976","unstructured":"Postgraduate Medical Journal (August 1976) 52, 535-538."},{"key":"ref_11","article-title":"Nail changes may occur in porphyria especially in the acute phase","volume-title":"personal communication) but the rarity of nail dystrophy is attested to by the absence of any reference to nail lesions occurring in porphyria in two major dermatological textbooks","author":"(Samman,","year":"1975","unstructured":"Nail changes may occur in porphyria especially in the acute phase (Dean, 1975, personal communication) but the rarity of nail dystrophy is attested to by the absence of any reference to nail lesions occurring in porphyria in two major dermatological textbooks (Samman, 1972; Cairns, 1972)."},{"key":"ref_12","article-title":"Among the nail changes that may be seen in porphyria are opaqueness, brown and bluish-grey discolorations, and loss of the lunule, but such changes are exceptionally rare in porphyria cutanea tarda compared with erythropoietic porphyria","volume-title":"Onycholysis, i.e. separation of the distal nail plate from its bed, has been observed in symptomatic porphyria (Tschudy, Magnus and Kalivas","year":"1970","unstructured":"Among the nail changes that may be seen in porphyria are opaqueness, brown and bluish-grey discolorations, and loss of the lunule, but such changes are exceptionally rare in porphyria cutanea tarda compared with erythropoietic porphyria (Degos, 1970). Onycholysis, i.e. separation of the distal nail plate from its bed, has been observed in symptomatic porphyria (Tschudy, Magnus and Kalivas, 1971)."},{"key":"ref_13","article-title":"Case report The patient was a 21-year-old married policewoman, with no previous history of a skin disorder either in herself or her family. In January, 1974, she noted brownish discoloration of the distal parts of some of her finger nails and thumbs. She was referred to the dermatology clinic by her general practitioner where the nail discoloration was diagnosed as onycholysis. In addition, numerous vesicles, erosions and pitted scars were noted on the dorsa of the hands and face, together with hypertrichosis of the face. Associated with these signs was a feeling of soreness in these regions on exposure to light. There were no symptoms referable to the abdominal or","unstructured":"Case report The patient was a 21-year-old married policewoman, with no previous history of a skin disorder either in herself or her family. In January, 1974, she noted brownish discoloration of the distal parts of some of her finger nails and thumbs. She was referred to the dermatology clinic by her general practitioner where the nail discoloration was diagnosed as onycholysis. In addition, numerous vesicles, erosions and pitted scars were noted on the dorsa of the hands and face, together with hypertrichosis of the face. Associated with these signs was a feeling of soreness in these regions on exposure to light. There were no symptoms referable to the abdominal or"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/610\/532\/50184921\/postgradmedj-52-532.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/610\/532\/50184921\/postgradmedj-52-532.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T06:37:21Z","timestamp":1683527841000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/52\/610\/532\/7037972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,8,1]]},"references-count":13,"journal-issue":{"issue":"610","published-online":{"date-parts":[[1976,8,1]]},"published-print":{"date-parts":[[1976,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.52.610.532","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1976,8]]},"published":{"date-parts":[[1976,8,1]]}}}