{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T07:11:00Z","timestamp":1683529860652},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"611","license":[{"start":{"date-parts":[[1976,9,1]],"date-time":"1976-09-01T00:00:00Z","timestamp":210384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Over the last 5 years plastic isolators have been used for the prevention of infection in patients with severe neutropenia. Fifteen patients in differing stages of acute myeloid and chronic granulocytic leukaemia were managed in isolators for a total of 110 patient-weeks. The mean duration of isolation for each patient was 7\u00b74 weeks with a range of 2-14 weeks. There was no evidence that any of the isolated patients acquired infection with any exogenous micro-organism. The psychological problems of isolation proved less onerous for the patients than had been anticipated by the medical and nursing staff and no patient had to be removed from isolation for psychiatric reasons. Unfortunately the reduced incidence of clinical infection in the isolated patients was not obviously associated with an increase in effectiveness of their anti-leukaemic treatment.<\/jats:p>","DOI":"10.1136\/pgmj.52.611.558","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"558-562","source":"Crossref","is-referenced-by-count":1,"title":["The use of plastic isolators to prevent infection in neutropenic patients"],"prefix":"10.1093","volume":"52","author":[{"given":"J M","family":"Goldman","sequence":"first","affiliation":[{"name":"M.R.C. Leukaemia Unit, Hammersmith Hospital , London W12 0HS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A S D","family":"Spiers","sequence":"additional","affiliation":[{"name":"M.R.C. Leukaemia Unit, Hammersmith Hospital , London W12 0HS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P C","family":"Trexler","sequence":"additional","affiliation":[{"name":"The Royal Veterinary College , Royal College Street, London NW1 0TU"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Gaya","sequence":"additional","affiliation":[{"name":"St Mary's Hospital Medical School , London W2 1PG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Gordon","sequence":"additional","affiliation":[{"name":"St Mary's Hospital Medical School , London W2 1PG"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1976,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.7326\/0003-4819-64-2-328","article-title":"Quantitative relationship between circulating leukocytes and infection in patients with acute leukemia","volume":"64","author":"BODEY, G.P.; BUCKLEY, M.; SATHE, Y.S.; FREIREICH, E.J.","year":"1966","unstructured":"BODEY, G.P., BUCKLEY, M., SATHE, Y.S. & FREIREICH, E.J. (1966) Quantitative relationship between circulating leukocytes and infection in patients with acute leukemia. Annals of Internal Medicine, 64, 328.","journal-title":"Annals of Internal Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/1097-0142(196811)22:5<1018::AID-CNCR2820220518>3.0.CO;2-0","article-title":"Studies of a patient isolator unit and prophylactic antibiotics in cancer chemotherapy: general techniques and preliminary results","volume":"22","author":"BODEY, G.P.; HART, J.; FREIREICH, E.J.; FREI, E.","year":"1968","unstructured":"BODEY, G.P., HART, J., FREIREICH, E.J. & FREI, E. (1968) Studies of a patient isolator unit and prophylactic antibiotics in cancer chemotherapy: general techniques and preliminary results. Cancer, 22, 1018.","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2141.1973.tb01741.x","article-title":"Phagocytic function of leucocytes from patients with acute myeloid and chronic granulocytic leukaemia","volume":"25","author":"GOLDMAN, J.M.; TH'NG, K.H.","year":"1974","unstructured":"GOLDMAN, J.M. & TH'NG, K.H. (1974) Phagocytic function of leucocytes from patients with acute myeloid and chronic granulocytic leukaemia. British Journal of Haematology, 25, 299.","journal-title":"British Journal of Haematology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000286922","article-title":"Psychological adaptation to isolator therapy in acute leukaemia","volume":"26","author":"GORDON, A.M.","year":"1975","unstructured":"GORDON, A.M. (1975a) Psychological adaptation to isolator therapy in acute leukaemia. Psychotherapy and Psychosomatics, 26, 132.","journal-title":"Psychotherapy and Psychosomatics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1192\/bjp.127.6.588","article-title":"Psychological aspects of isolator therapy in acute leukaemia","volume":"127","author":"GORDON, A.M.","year":"1975","unstructured":"GORDON, A.M. (1975b) Psychological aspects of isolator therapy in acute leukaemia. British Journal of Psychiatry, 127, 588.","journal-title":"British Journal of Psychiatry"},{"key":"ref_6","first-page":"105","article-title":"Causes of death in acute leukemia: a ten-year study of 414 patients from 1954-1963","volume":"193","author":"HERSH, E.M.; BODEY, G.P.; NiEs, B.A.; FREIREICH, E.J.","year":"1963","unstructured":"HERSH, E.M., BODEY, G.P., NiEs, B.A. & FREIREICH, E.J. (1963) Causes of death in acute leukemia: a ten-year study of 414 patients from 1954-1963. Journal of American Medical Association, 193, 105.","journal-title":"Journal of American Medical Association"},{"key":"ref_7","article-title":"Five-year analysis of protective isolation","volume":"1034","author":"JAMESON, B.; GAMBLE, D.R.; LYNCH, J.; KAY, H.E.M.","year":"1971","unstructured":"JAMESON, B., GAMBLE, D.R., LYNCH, J. & KAY, H.E.M. (1971) Five-year analysis of protective isolation. Lancet, i, 1034.","journal-title":"Lancet"},{"key":"ref_8","first-page":"141","article-title":"Hematologic malignancies and other marrow failure states: progress in the management of complicating infections","volume":"11","author":"LEVINE, A.S.; SCHIMPFF, S.C.; GRAW, R.G.; YOUNG, R.C.","year":"1974","unstructured":"LEVINE, A.S., SCHIMPFF, S.C., GRAW, R.G. & YOUNG, R.C. (1974) Hematologic malignancies and other marrow failure states: progress in the management of complicating infections. Seminars in Hematology, 11, 141.","journal-title":"Seminars in Hematology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1056\/NEJM197303082881001","article-title":"Protected environments and prophylactic antibiotics. A prospective controlled study of their utility in the therapy of acute leukemia","volume":"288","author":"LEVINE, A.S.; SIEGEL, S.E.; SCHREIBER, A.D.; HAUSER, J.; PREISLER, H.; GOLDSTEIN, I.M.; SEIDLER, F.; SIMON, R.; PERRY, S.; BENNETT, J.E.; HENDERSON, E.S.","year":"1973","unstructured":"LEVINE, A.S., SIEGEL, S.E., SCHREIBER, A.D., HAUSER, J., PREISLER, H., GOLDSTEIN, I.M., SEIDLER, F., SIMON, R., PERRY, S., BENNETT, J.E. & HENDERSON, E.S. (1973) Protected environments and prophylactic antibiotics. A prospective controlled study of their utility in the therapy of acute leukemia. New England Journal of Medicine, 288, 477.","journal-title":"New England Journal of Medicine"},{"key":"ref_10","article-title":"Portable laminar-air-flow isolator","volume":"174","author":"PENLAND, W.Z.; PERRY, S.","year":"1970","unstructured":"PENLAND, W.Z. & PERRY, S. (1970) Portable laminar-air-flow isolator. Lancet, i, 174.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.7326\/0003-4819-82-3-351","article-title":"Infection prevention in acute nonlymphocytic leukemia. Laminar air flow room reverse isolation with oral, nonabsorbable antibiotic prophylaxis","volume":"82","author":"SCHIMPFF, S.C.; GREENE, W.H.; YOUNG, V.M.; FORTNER, C.L.; JEPSEN, L.; CUSACK, N.; BLOCK, J.B.; WIERNIK, P.H.","year":"1975","unstructured":"SCHIMPFF, S.C., GREENE, W.H., YOUNG, V.M., FORTNER, C.L., JEPSEN, L., CUSACK, N., BLOCK, J.B. & WIERNIK, P.H. (1975) Infection prevention in acute nonlymphocytic leukemia. Laminar air flow room reverse isolation with oral, nonabsorbable antibiotic prophylaxis. Annals of Internal Medicine, 82, 351.","journal-title":"Annals of Internal Medicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"707","DOI":"10.7326\/0003-4819-77-5-707","article-title":"Origin of infection in acute nonlymphocytic leukemia. Significance of hospital acquisition of potential pathogens","volume":"77","author":"SCHIMPFF, S.C.; YOUNG, V.M.; GREENE, W.H.; VERMEULEN, G.D.; MOODY, M.R.; WIERNIK, P.H.","year":"1972","unstructured":"SCHIMPFF, S.C., YOUNG, V.M., GREENE, W.H., VERMEULEN, G.D., MOODY, M.R. & WIERNIK, P. H. (1972) Origin of infection in acute nonlymphocytic leukemia. Significance of hospital acquisition of potential pathogens. Annals of Internal Medicine, 77, 707.","journal-title":"Annals of Internal Medicine"},{"key":"ref_13","first-page":"66","article-title":"The use of a plastic isolator for the prevention of infection in patients with acute leukaemia","volume":"231","author":"SPIERS, A.S.D.; TREXLER, P.C.","year":"1973","unstructured":"SPIERS, A.S.D. & TREXLER, P.C. (1973) The use of a plastic isolator for the prevention of infection in patients with acute leukaemia. Journal of Physiology, 231, 66P.","journal-title":"Journal of Physiology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1136\/bmj.4.5996.549","article-title":"Plastic isolators for treatment of acute leukaemia patients under 'germ-free' conditions","volume":"4","author":"TREXLER, P.C.; SPIERS, A.S.D.; GAYA, H.","year":"1975","unstructured":"TREXLER, P.C., SPIERS, A.S.D. & GAYA, H. (1975) Plastic isolators for treatment of acute leukaemia patients under 'germ-free' conditions. British Medical Journal, 4, 549.","journal-title":"British Medical Journal"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/611\/558\/50184974\/postgradmedj-52-558.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/611\/558\/50184974\/postgradmedj-52-558.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T06:37:37Z","timestamp":1683527857000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/52\/611\/558\/7037944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,9,1]]},"references-count":14,"journal-issue":{"issue":"611","published-online":{"date-parts":[[1976,9,1]]},"published-print":{"date-parts":[[1976,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.52.611.558","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1976,9]]},"published":{"date-parts":[[1976,9,1]]}}}