{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:26:44Z","timestamp":1759541204217},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"612","license":[{"start":{"date-parts":[[1976,10,1]],"date-time":"1976-10-01T00:00:00Z","timestamp":212976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,10,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The growth-inhibiting effect of exogenous corticosteroids has been reported in many papers. Most of them have concerned the clinical problems of asthma and rheumatoid arthritis but it is probable that the underlying disease is relatively unimportant in determining the effect on growth. Steroid therapy on alternate days seems to produce less undesirable effects than steroid treatment every day and corticotrophin may be preferable. Although the mechanisms are uncertain it seems likely that the action is peripheral and certainly exogenous growth hormone does not prevent the steroid effect. A minimal dosage of corticosteroids should always be used in replacement therapy for hypopituitarism.<\/jats:p>","DOI":"10.1136\/pgmj.52.612.625","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:31:39Z","timestamp":1230582699000},"page":"625-630","source":"Crossref","is-referenced-by-count":42,"title":["The effect of administered corticosteroids on the growth of children"],"prefix":"10.1093","volume":"52","author":[{"given":"M A","family":"Preece","sequence":"first","affiliation":[{"name":"Department of Growth and Development, Institute of Child Health, University of London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1976,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0022-3476(74)80277-5","article-title":"Experience with long-term therapy in congenital adrenal hyperplasia","volume":"85","author":"BROOK, C.G.D.; ZACHMAN, M.; PRADER, A.; MURSET, G.","year":"1974","unstructured":"BROOK, C.G.D., ZACHMAN, M., PRADER, A. & MURSET, G. (1974) Experience with long-term therapy in congenital adrenal hyperplasia. Journal of Pediatrics, 85, 12.","journal-title":"Journal of Pediatrics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1177\/003591576505800843","article-title":"The present status of steroid treatment in rheumatoid arthritis","volume":"58","author":"BYWATERS, E.G.L.","year":"1965","unstructured":"BYWATERS, E.G.L. (1965) The present status of steroid treatment in rheumatoid arthritis. Proceedings of the Royal Society of Medicine, 58, 649.","journal-title":"Proceedings of the Royal Society of Medicine"},{"key":"ref_3","first-page":"521","article-title":"Comparison of effects of long-term corticotrophin and corticosteroid treatment on responses of plasma growth hormone, ACTH, and corticosteroid to hypoglycaemia","volume":"3","author":"DALY, J.R.; FLETCHER, M.R.; GLASS, D.; CHAMBERS, D.J.; BITENSKY, L.; CHAYEN, J.","year":"1974","unstructured":"DALY, J.R., FLETCHER, M.R., GLASS, D., CHAMBERS, D.J., BITENSKY, L. & CHAYEN, J. (1974) Comparison of effects of long-term corticotrophin and corticosteroid treatment on responses of plasma growth hormone, ACTH, and corticosteroid to hypoglycaemia. British Medical Journal, 3, 521.","journal-title":"British Medical Journal"},{"key":"ref_4","first-page":"127","article-title":"Childhood asthma and steroid therapy as influences on growth","volume":"105","author":"FALLIERS, C.J.; TAN, L.S.; SZENTIVANYI, J.; JORGENSEN, J.R.; BUKANTZ, S.C.","year":"1963","unstructured":"FALLIERS, C.J., TAN, L.S., SZENTIVANYI, J., JORGENSEN, J.R. & BUKANTZ, S.C. (1963) Childhood asthma and steroid therapy as influences on growth. American Journal of Diseases of Children, 105, 127.","journal-title":"American Journal of Diseases of Children"},{"key":"ref_5","article-title":"Effects of long-term corticosteroids and corticotrophin on the growth of children","volume":"568","author":"FRIEDMAN, M.; STRANG, L.B.","year":"1966","unstructured":"FRIEDMAN, M. & STRANG, L.B. (1966) Effects of long-term corticosteroids and corticotrophin on the growth of children. Lancet, ii, 568.","journal-title":"Lancet"},{"key":"ref_6","article-title":"Radiographic Atlas of Skeletal Development of the Hand and Wrist, second edition","author":"GREULICH, W.W.; PYLE, S.I.","year":"1959","unstructured":"GREULICH, W.W. & PYLE, S.I. (1959) Radiographic Atlas of Skeletal Development of the Hand and Wrist, second edition. Stanford University Press, California."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1530\/acta.0.0660491","article-title":"Effect of administration of human growth hormone on sulphation factor activity in serum of hypopituitary patients","volume":"66","author":"HALL, K.","year":"1971","unstructured":"HALL, K. (1971) Effect of administration of human growth hormone on sulphation factor activity in serum of hypopituitary patients. Acta endocrinologica, 66, 491.","journal-title":"Acta endocrinologica"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1530\/acta.0.0690417","article-title":"Sulphation factor activity and growth rate during long-term treatment of patients with pituitary dwarfism with human growth hormone","volume":"69","author":"HALL, K.; OLIN, P.","year":"1972","unstructured":"HALL, K. & OLIN, P. (1972) Sulphation factor activity and growth rate during long-term treatment of patients with pituitary dwarfism with human growth hormone. Acta endocrinologica, 69, 417.","journal-title":"Acta endocrinologica"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1136\/adc.43.231.556","article-title":"Effect on height of corticosteroid therapy in asthmatic children","volume":"43","author":"KERREBIJN, K.F.; KROON, J.P.M.","year":"1968","unstructured":"KERREBIJN, K.F. & KROON, J.P.M. (1968) Effect on height of corticosteroid therapy in asthmatic children. Archives of Disease in Childhood, 43, 556.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0022-3476(73)80373-7","article-title":"Growth and development of children with renal transplants. Use of alternate day steroid therapy","volume":"83","author":"McENERY, P.T.; GONZALEZ, L.L.; MARTIN, L.W.; WEST, C.D.","year":"1973","unstructured":"McENERY, P.T., GONZALEZ, L.L., MARTIN, L.W. & WEST, C.D. (1973) Growth and development of children with renal transplants. Use of alternate day steroid therapy. Journal of Pediatrics, 83, 806.","journal-title":"Journal of Pediatrics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1203\/00006450-197507000-00005","article-title":"Growth and skeletal maturation in asthmatic children: effect of corticosteroid treatment","volume":"9","author":"MORRIS, H.G.","year":"1975","unstructured":"MORRIS, H.G. (1975) Growth and skeletal maturation in asthmatic children: effect of corticosteroid treatment. Pediatric Research, 9, 579.","journal-title":"Pediatric Research"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1172\/JCI105740","article-title":"Metabolic effects of human growth hormone in corticosteroid-treated children","volume":"47","author":"MORRIS, H.G.; JORGENSEN, J.R.; ELRICK, H.; GOLDSMITH, R.E.","year":"1968","unstructured":"MORRIS, H.G., JORGENSEN, J.R., ELRICK, H. & GOLDSMITH, R.E. (1968) Metabolic effects of human growth hormone in corticosteroid-treated children. Journal of Clinical Investigation, 47, 436.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_13","article-title":"Studies of sulphation in vitro by rib cartilage of rats undergoing growth arrest and recovery","volume-title":"Educazione Permanente 2, Supplement 1, Abstract 42","author":"MOSIER, Jr, H.D.; JANSONS, S.R.A.","year":"1975","unstructured":"MOSIER, H.D., Jr & JANSONS, S.R.A. (1975) Studies of sulphation in vitro by rib cartilage of rats undergoing growth arrest and recovery. Ricerca Scientifica ed Educazione Permanente 2, Supplement 1, Abstract 42."},{"key":"ref_14","article-title":"Effect of corticotrophin on skeletal maturation and linear growth in six patients with severe asthma","volume":"287","author":"NORMAN, A.P.; SANDFRS, S.","year":"1979","unstructured":"NORMAN, A.P. & SANDFRS, S. (1979) Effect of corticotrophin on skeletal maturation and linear growth in six patients with severe asthma. Lancet, i, 287.","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0022-3476(63)80035-9","article-title":"Catch-up growth following illness or starvation","volume":"62","author":"PRADER, A.; TANNER, J.M.; HARNACK, V.O.N.; A, G.","year":"1963","unstructured":"PRADER, A., TANNER, J.M. & VON HARNACK, G.A. (1963) Catch-up growth following illness or starvation. Journal of Pediatrics, 62, 646.","journal-title":"Journal of Pediatrics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1001\/archderm.1961.01580120092023","article-title":"Alternate-day corticosteroid therapy","volume":"83","author":"REICHLING, G.H.; KLIGMAN, A.M.","year":"1961","unstructured":"REICHLING, G.H. & KLIGMAN, A.M. (1961) Alternate-day corticosteroid therapy. Archives of Dermatology, 83, 980.","journal-title":"Archives of Dermatology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1172\/JCI107256","article-title":"Diurnal variation in the responsiveness of humani subjects to human growth hormone","volume":"52","author":"RUDMAN, D.; FREIDES, D.; PATTERSON, J.H.; GIBBAS, D.L.","year":"1973","unstructured":"RUDMAN, D., FREIDES, D., PATTERSON, J.H. & GIBBAS, D.L. (1973) Diurnal variation in the responsiveness of humani subjects to human growth hormone. Jouirnal of Clinical Investigation, 52, 912.","journal-title":"Jouirnal of Clinical Investigation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1542\/peds.43.2.277","article-title":"Adrenal function, growth, and insulin in patients treated with corticoids on alternate days","volume":"43","author":"SADEGHI-NEJAD, A.; SENIOR, B.","year":"1969","unstructured":"SADEGHI-NEJAD, A. & SENIOR, B. (1969) Adrenal function, growth, and insulin in patients treated with corticoids on alternate days. Pediatrics, 43, 277.","journal-title":"Pediatrics"},{"key":"ref_19","first-page":"207","article-title":"Growth retardation in Cushing's syndrome","volume":"123","author":"STRICKLAND, A.L.; UNDERWOOD, L.E.; VOINA, S.J.; FRENCH, F.S.; WYK, V.A.N.; J, J.","year":"1972","unstructured":"STRICKLAND, A.L., UNDERWOOD, L.E., VOINA, S.J., FRENCH, F.S. & VAN WYK, J.J. (1972) Growth retardation in Cushing's syndrome. American Journal of Diseases of Children, 123, 207.","journal-title":"American Journal of Diseases of Children"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1136\/bmj.3.5722.547","article-title":"Cortisol and growth secretion in relation to linear growth: Patients with Still's disease on different therapeutic regimes","volume":"3","author":"STURGE, R.A.; BEARDWELL, C.; HARTOG, M.; WRIGHT, D.; ANSELL, B.M.","year":"1970","unstructured":"STURGE, R.A., BEARDWELL, C., HARTOG, M., WRIGHT, D. & ANSELL, B.M. (1970) Cortisol and growth secretion in relation to linear growth: Patients with Still's disease on different therapeutic regimes. British Medical Journal, 3, 547.","journal-title":"British Medical Journal"},{"key":"ref_21","first-page":"745","article-title":"Effects of human growth hormone treatment","volume-title":"Archives of Disease in Childhood; growth of 100 children, with growth hormone deficiency, low birthweight, inherited smallness, Turner's syndrome, and other complaints","volume":"46","author":"TANNER, J.M.; WHITEHOUSE, R.H.; HUGHES, P.C.R.; VINCE, F.P.","year":"1971","unstructured":"TANNER, J.M., WHITEHOUSE, R.H., HUGHES, P.C.R. & VINCE, F.P. (1971) Effects of human growth hormone treatment for 1 to 7 years on growth of 100 children, with growth hormone deficiency, low birthweight, inherited smallness, Turner's syndrome, and other complaints. Archives of Disease in Childhood, 46, 745."},{"key":"ref_22","article-title":"Plasma somatomedin activity","volume-title":"clinical conditions, Ricerca Scientifica ed Educazione Permanente 2, Supplement 1, Abstract 82","author":"BRANDE, V.A.N.D.E.N.; L, J.","year":"1975","unstructured":"VAN DEN BRANDE, J.L. (1975) Plasma somatomedin activity in clinical conditions, Ricerca Scientifica ed Educazione Permanente 2, Supplement 1, Abstract 82."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1210\/jcem-33-1-14","article-title":"Twenty-fourhour pattern of the episodic secretion of cortisol in normal subjects","volume":"33","author":"WEITZMAN, E.D.; FUKUSHIMA, D.; NOGEIRE, C.; ROFFWARG, H.; GALLAGHER, T.F.; HELLMAN, L.","year":"1971","unstructured":"WEITZMAN, E.D., FUKUSHIMA, D., NOGEIRE, C., ROFFWARG, H., GALLAGHER, T.F. & HELLMAN, L. (1971) Twenty-fourhour pattern of the episodic secretion of cortisol in normal subjects. Journal of Clinical E'ndocrinology and Metabolism, 33, 14.","journal-title":"Journal of Clinical E'ndocrinology and Metabolism"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1136\/adc.46.249.584","article-title":"Corticotrophin therapy in juvenile chronic polyarthritis (Still's disease) and effect on growth","volume":"46","author":"ZUTSHI, D.M.; FRIEDMAN, M.; ANSELL, B.M.","year":"1971","unstructured":"ZUTSHI, D.M., FRIEDMAN, M. & ANSELL, B.M. (1971) Corticotrophin therapy in juvenile chronic polyarthritis (Still's disease) and effect on growth. Archives of Disease in Childhood, 46, 584.","journal-title":"Archives of Disease in Childhood"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/612\/625\/50185234\/postgradmedj-52-625.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/52\/612\/625\/50185234\/postgradmedj-52-625.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T06:20:50Z","timestamp":1684822850000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/52\/612\/625\/7038064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,10,1]]},"references-count":24,"journal-issue":{"issue":"612","published-online":{"date-parts":[[1976,10,1]]},"published-print":{"date-parts":[[1976,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.52.612.625","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1976,10]]},"published":{"date-parts":[[1976,10,1]]}}}