{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:19:54Z","timestamp":1761016794439},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"615","license":[{"start":{"date-parts":[[1977,1,1]],"date-time":"1977-01-01T00:00:00Z","timestamp":220924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 71-year-old woman with myxoedema coma presenting in status epilepticus is reported. Although this complication of myxoedema coma is considered to be fatal the patient described responded dramatically to treatment and remains in good health.<\/jats:p>","DOI":"10.1136\/pgmj.53.615.46","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"46-48","source":"Crossref","is-referenced-by-count":14,"title":["Myxoedema coma presenting in status epilepticus"],"prefix":"10.1093","volume":"53","author":[{"given":"K L","family":"Woods","sequence":"first","affiliation":[{"name":"Selly Oak Hospital , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G K","family":"Holmes","sequence":"additional","affiliation":[{"name":"Selly Oak Hospital , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/00000441-197212000-00001","article-title":"Myxedema coma","volume":"264","author":"BLUM, M.","year":"1972","unstructured":"BLUM, M. (1972) Myxedema coma. American Journal of the Medical Sciences, 264, 432.","journal-title":"American Journal of the Medical Sciences"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.7326\/0003-4819-52-2-434","article-title":"Neurological complications of myxedema convulsions","volume":"52","author":"EVANS, E.C.","year":"1960","unstructured":"EVANS, E.C. (1960) Neurological complications of myxedema convulsions. Annals of Internal Medicine, 52, 434.","journal-title":"Annals of Internal Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1136\/jcp.18.5.660","article-title":"Serum enzymes in diseases of the thyroid gland","volume":"18","author":"GRIFFITHS, P.D.","year":"1965","unstructured":"GRIFFITHS, P.D. (1965) Serum enzymes in diseases of the thyroid gland. Journal of Clinical Pathology, 18, 660.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_4","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(62)92700-9","article-title":"Fits, faints, coma and dementia in myxoedema","author":"JELLINEK, E.H.","year":"1962","unstructured":"JELLINEK, E.H. (1962) Fits, faints, coma and dementia in myxoedema. Lancet,;;, 1010.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/0002-9343(55)90179-0","article-title":"Fatal coma due to myxedema","volume":"18","author":"LEVIN, M.E.; DAUGHADAY, W.H.","year":"1955","unstructured":"LEVIN, M.E. & DAUGHADAY, W.H. (1955) Fatal coma due to myxedema. American Journal of Medicine, 18, 1017.","journal-title":"American Journal of Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1136\/pgmj.47.548.361","article-title":"Syncope in myxoedema due to transient ventricular fibrillation","volume":"47","author":"MACAULEY, M.B.; SHEPHERD, R.J.","year":"1971","unstructured":"MACAULEY, M.B. & SHEPHERD, R.J. (1971) Syncope in myxoedema due to transient ventricular fibrillation. Postgraduate Medical Journal, 47, 361.","journal-title":"Postgraduate Medical Journal"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/bmj.4.5895.757","article-title":"Acute pancreatitis and diabetic keto-acidosis in accidental hypothermia and hypothermic myxoedema","volume":"4","author":"MACLEAN, D.; MURISON, J.; GRIFFITHS, P.D.","year":"1973","unstructured":"MACLEAN, D., MURISON, J. & GRIFFITHS, P.D. (1973) Acute pancreatitis and diabetic keto-acidosis in accidental hypothermia and hypothermic myxoedema. British Medical Journal, 4, 757.","journal-title":"British Medical Journal"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1136\/bmj.2.5157.932","article-title":"Hypothermia after chlorpromazine in myxoedematous psychosis","volume":"2","author":"MITCHELL, J.R.A.; SURRIDGE, D.H.C.; WILLISON, R.G.","year":"1959","unstructured":"MITCHELL, J.R.A., SURRIDGE, D.H.C. & WILLISON, R.G. (1959) Hypothermia after chlorpromazine in myxoedematous psychosis. British Medical Jouirnal, 2, 932.","journal-title":"British Medical Jouirnal"},{"key":"ref_9","first-page":"353","article-title":"Myxoedema coma. Two case reports and a review","volume":"45","author":"NEILSEN, P.E.; RANL0V, P.","year":"1964","unstructured":"NEILSEN, P.E. & RANL0V, P. (1964) Myxoedema coma. Two case reports and a review. Acta endocrinologica, 45, 353.","journal-title":"Acta endocrinologica"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1136\/bmj.1.5131.1204","article-title":"The electroencephalogram in myxoedema coma","volume":"1","author":"NIEMAN, E.A.","year":"1959","unstructured":"NIEMAN, E.A. (1959) The electroencephalogram in myxoedema coma. British Medical Journal, 1, 1204.","journal-title":"British Medical Journal"},{"key":"ref_11","first-page":"48","article-title":"Postgraduate Medical Journal (Jauuary","volume":"53","year":"1977","unstructured":"Postgraduate Medical Journal (Jauuary 1977) 53, 48-49."},{"key":"ref_12","article-title":"Introduction The development of neoplasms after immunosuppressive therapy has been reported previously (Doll and Kinlen","volume-title":"The great majority have been either of the lymphoreticular type, frequently involving the central nervous system, or cancers involving superficial epithelium. The occurrence of a poorly differentiated sarcoma in a patient during treatment with cyclophosphamide is reported","year":"1970","unstructured":"Introduction The development of neoplasms after immunosuppressive therapy has been reported previously (Doll and Kinlen, 1970). The great majority have been either of the lymphoreticular type, frequently involving the central nervous system, or cancers involving superficial epithelium. The occurrence of a poorly differentiated sarcoma in a patient during treatment with cyclophosphamide is reported."},{"key":"ref_13","article-title":"Case history The patient, a janitor aged 62, initially presented in August 1969 with painful hands and feet. A diagnosis of seropositive rheumatoid arthritis was made and treated with chloroquine phosphate 250 mg daily for 1 year. In November 1972 there was an exacerbation of his joint symptoms and he was started on prednisolone 15 mg daily but continuing disease activity necessitated the addition of cyclophosphamide 50 mg twice daily in February","year":"1975","unstructured":"Case history The patient, a janitor aged 62, initially presented in August 1969 with painful hands and feet. A diagnosis of seropositive rheumatoid arthritis was made and treated with chloroquine phosphate 250 mg daily for 1 year. In November 1972 there was an exacerbation of his joint symptoms and he was started on prednisolone 15 mg daily but continuing disease activity necessitated the addition of cyclophosphamide 50 mg twice daily in February 1975."},{"key":"ref_14","article-title":"he was admitted to the Manchester Royal Infirmary. There was a 2-month history of progressive exertional dyspnoea and 10 kg weightloss. Examination revealed a hypercorticoid cyanosed patient with finger clubbing, a left pleural effusion and chronic rheumatoid joint changes. Investigations showed a haemoglobin of 13-6 g\/100 ml; white cell count of 6,900 with a normal differential; an ESR of 40 mm in 1 hr (Westergren). Routine biochemical tests were all normal. A chest X-ray film confirmed the presence of a left pleural effusion. Cytological examination of the blood-stained pleural aspirate showed it to contain neoplastic cells and needle biopsy of the pleura revealed infiltration with anaplastic tumour cells","author":"August","year":"1975","unstructured":"In August 1975 he was admitted to the Manchester Royal Infirmary. There was a 2-month history of progressive exertional dyspnoea and 10 kg weightloss. Examination revealed a hypercorticoid cyanosed patient with finger clubbing, a left pleural effusion and chronic rheumatoid joint changes. Investigations showed a haemoglobin of 13-6 g\/100 ml; white cell count of 6,900 with a normal differential; an ESR of 40 mm in 1 hr (Westergren). Routine biochemical tests were all normal. A chest X-ray film confirmed the presence of a left pleural effusion. Cytological examination of the blood-stained pleural aspirate showed it to contain neoplastic cells and needle biopsy of the pleura revealed infiltration with anaplastic tumour cells."},{"key":"ref_15","article-title":"Discussion The alkylating agent cyclophosphamide appears to be an effective therapeutic agent in certain connective tissue disorders including rheumatoid arthritis (Cooperating Clinics Committee","volume-title":"The adverse side effects of this drug constitute a major limitation to its widespread clinical use and in particular there is a possible risk of malignant transformation. A full","year":"1970","unstructured":"Discussion The alkylating agent cyclophosphamide appears to be an effective therapeutic agent in certain connective tissue disorders including rheumatoid arthritis (Cooperating Clinics Committee, 1970). The adverse side effects of this drug constitute a major limitation to its widespread clinical use and in particular there is a possible risk of malignant transformation. A full"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/615\/46\/50185032\/postgradmedj-53-46.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/615\/46\/50185032\/postgradmedj-53-46.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T06:49:53Z","timestamp":1683528593000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/53\/615\/46\/7038241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1,1]]},"references-count":15,"journal-issue":{"issue":"615","published-online":{"date-parts":[[1977,1,1]]},"published-print":{"date-parts":[[1977,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.53.615.46","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1977,1]]},"published":{"date-parts":[[1977,1,1]]}}}