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The buccal absorption of indomethacin over the pH range 5-9 was also studied in normal volunteers, and showed that the percentage absorption increased markedly as the pH was reduced. The clinical importance both of pH-partition and of adsorption are discussed in the context of antacid interactions. It is concluded that caution must be exercised when prescribing an antacid with other orally-administered drugs.<\/jats:p>","DOI":"10.1136\/pgmj.53.617.126","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"126-129","source":"Crossref","is-referenced-by-count":8,"title":["The different effects of sodium bicarbonate and aluminium hydroxide on the absorption of indomethacin in man"],"prefix":"10.1093","volume":"53","author":[{"given":"J C","family":"Garnham","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, St Bartholomew's Hospital , London EC1A 7BE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kaspi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, St Bartholomew's Hospital , London EC1A 7BE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C M","family":"Kaye","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, St Bartholomew's Hospital , London EC1A 7BE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V M","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, St Bartholomew's Hospital , London EC1A 7BE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/cpt1973142231","article-title":"Effect of coadministration of aluminium and magnesium hydroxide on absorption of anticoagulants in man","volume":"14","author":"AMBRE, J.J.; FISCHER, L.J.","year":"1973","unstructured":"AMBRE, J.J. & FISCHER, L.J. 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