{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:25:17Z","timestamp":1759541117475},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"617","license":[{"start":{"date-parts":[[1977,3,1]],"date-time":"1977-03-01T00:00:00Z","timestamp":226022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,3,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A new-born baby with Beckwith's syndrome had severe hypoglycaemia, and was treated with glucagon and prednisone. Treatment was stopped at 1 month of age and his blood glucose levels were satisfactory for the ensuing 6 weeks. However, at 10 weeks of age, he had a hypoglycaemic convulsion and required large doses of diazoxide and prednisone for the next 2 months to maintain the blood glucose above 40 mg\/100 ml. Insulin excretion was raised until he was 4 months old. Cases of Beckwith's syndrome which develop hypoglycaemia, should be treated with diazoxide and corticosteroids until insulin excretion is normal.<\/jats:p>","DOI":"10.1136\/pgmj.53.617.159","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"159-161","source":"Crossref","is-referenced-by-count":12,"title":["Management of prolonged hypoglycaemia in Beckwith's syndrome"],"prefix":"10.1093","volume":"53","author":[{"given":"M W","family":"Moncrieff","sequence":"first","affiliation":[{"name":"Special Care Baby Unit and Derbyshire Children's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K A","family":"Lacey","sequence":"additional","affiliation":[{"name":"Special Care Baby Unit and Derbyshire Children's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P N","family":"Malleson","sequence":"additional","affiliation":[{"name":"Special Care Baby Unit and Derbyshire Children's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,3,1]]},"reference":[{"key":"ref_1","first-page":"188","article-title":"Macroglossia, omphalocele, adrenal cytomegaly, gigantism and hyperplastic visceromegaly","volume":"5","author":"BECKWITH, J.B.","year":"1969","unstructured":"BECKWITH, J.B. (1969) Macroglossia, omphalocele, adrenal cytomegaly, gigantism and hyperplastic visceromegaly. Birth Defects: Original Article Series, 5, 188.","journal-title":"Birth Defects: Original Article Series"},{"key":"ref_2","first-page":"236","article-title":"Hyperplastic fetal visceromegaly with macroglossia, omphalocele, cytomegaly of adrenal fetal cortex, postnatal somatic gigantism, and other abnormalities: newly recognized syndrome","volume":"275","author":"BECKWITH, J.B.; WANG, C.; DONNELL, G.N.; GWINN, J.L.","year":"1964","unstructured":"BECKWITH, J.B., WANG, C., DONNELL, G.N. & GWINN, J.L. (1964) Hyperplastic fetal visceromegaly with macroglossia, omphalocele, cytomegaly of adrenal fetal cortex, postnatal somatic gigantism, and other abnormalities: newly recognized syndrome. Proceedings of the American Pediatric Society, June (16-18) (Abst. No. 41). COMBS, J.T., GRUNT, J.A. & BRANDT, I.K. (1966) New syndrome of neonatal hypoglycaemia; association with visceromegaly, macroglossia, microcephaly, and abnormal umbilicus. New England Journal of Medicine, 275, 236.","journal-title":"Proceedings of the American Pediatric Society; New syndrome"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0022-3476(73)80509-8","article-title":"Diazoxide therapy in the syndrome of Beckwith-Weidemann-Coombs","volume":"83","author":"GOTLIN, R.W.","year":"1973","unstructured":"GOTLIN, R.W. (1973) Diazoxide therapy in the syndrome of Beckwith-Weidemann-Coombs. Journal of Pediatrics, 83, 342.","journal-title":"Journal of Pediatrics"},{"key":"ref_4","first-page":"337","article-title":"Hypoglyc6mie du nouveau-n6 avec microc6phalie, macroglossie et m6galosplanchnie","volume":"26","author":"MARIANI, R.; UNAL, D.; SPRIET, A.; CARCASSONNE, M.; BERNARD, R.","year":"1969","unstructured":"MARIANI, R., UNAL, D., SPRIET, A., CARCASSONNE, M. & BERNARD, R. (1969) Hypoglyc6mie du nouveau-n6 avec microc6phalie, macroglossie et m6galosplanchnie. Archives Fran,aises de P'diatrie, 26, 337.","journal-title":"Archives Fran, aises de P'diatrie"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1542\/peds.52.3.372","article-title":"Beckwith's syndrome with extreme organ hyperplasia","volume":"52","author":"ROE, T.F.; KERSHNAR, A.K.; WEITZMAN, J.J.; MADRIGAL, L.S.","year":"1973","unstructured":"ROE, T.F., KERSHNAR, A.K., WEITZMAN, J.J. & MADRIGAL, L.S. (1973) Beckwith's syndrome with extreme organ hyperplasia. Pediatrics, 52, 372.","journal-title":"Pediatrics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0022-3476(73)80163-5","article-title":"Metabolic aspects of the Beckwith-Weidemann syndrome","volume":"82","author":"SCHIFF, D.; COLLE, E.; WELLS, D.; STERN, L.","year":"1973","unstructured":"SCHIFF, D., COLLE, E., WELLS, D. & STERN, L. (1973) Metabolic aspects of the Beckwith-Weidemann syndrome. Journal of Pediatrics, 82, 258.","journal-title":"Journal of Pediatrics"},{"key":"ref_7","first-page":"161","volume":"53","author":"Journal, Postgraduate Medical","year":"1977","unstructured":"Postgraduate Medical Journal (March 1977) 53, 161-164."},{"key":"ref_8","article-title":"Introduction In 1951, McArdle reported the case of a 30-year-","unstructured":"Introduction In 1951, McArdle reported the case of a 30-year-"},{"key":"ref_9","article-title":"old man who had suffered from life-long muscular pain on slight exertion, progressing on continued exertion to weakness and stiffness. These symptoms usually disappeared on resting. Localized swellings in muscle and abnormal shortening of flexor muscles were seen to occur after ischaemic exercise. Electromyography showed that muscle shortening was a reversible physiological contracture of the muscle fibre not associated with any conducted action potential in the muscle. An important finding was the absence of the normal rise in blood lactic acid on ischaemic exercise. Subsequently, further cases were reported by Pearson, Rimmer and Mommaerts","volume-title":"(1959), Schmid and Mahler (1959), Mellick, Mahler and Hughes (1962) and Schmid and Hammaker (1961), and in; blood lactic acid level failed to rise on ischaemic exercise. Histochemical study of muscles from these patients","author":"all instances the","unstructured":"old man who had suffered from life-long muscular pain on slight exertion, progressing on continued exertion to weakness and stiffness. These symptoms usually disappeared on resting. Localized swellings in muscle and abnormal shortening of flexor muscles were seen to occur after ischaemic exercise. Electromyography showed that muscle shortening was a reversible physiological contracture of the muscle fibre not associated with any conducted action potential in the muscle. An important finding was the absence of the normal rise in blood lactic acid on ischaemic exercise. Subsequently, further cases were reported by Pearson, Rimmer and Mommaerts (1959), Schmid and Mahler (1959), Mellick, Mahler and Hughes (1962) and Schmid and Hammaker (1961), and in all instances the blood lactic acid level failed to rise on ischaemic exercise. Histochemical study of muscles from these patients"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/617\/159\/50185178\/postgradmedj-53-159.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/617\/159\/50185178\/postgradmedj-53-159.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T06:29:49Z","timestamp":1684823389000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/53\/617\/159\/7038234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,3,1]]},"references-count":9,"journal-issue":{"issue":"617","published-online":{"date-parts":[[1977,3,1]]},"published-print":{"date-parts":[[1977,3,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.53.617.159","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1977,3]]},"published":{"date-parts":[[1977,3,1]]}}}