{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:52:30Z","timestamp":1759009950907},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"618","license":[{"start":{"date-parts":[[1977,4,1]],"date-time":"1977-04-01T00:00:00Z","timestamp":228700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>This article reviews the current place of erythromycin in antibiotic therapy. Overall, erythromycin is thought to be underused because: (1) the fear of resistance has been exaggerated; (2) significant toxicity has been associated with only one derivative (the estolate); (3) newer antibiotics have very rarely been demonstrated to be superior to erythromycin. Erythromycin has an important place in treating acute upper and lower respiratory tract infections, acute otitis media, sinusitis, skin and soft tissue, osteomyelitis, prostatitis, infections due to Mycoplasma spp. and Chlamydia organisms, and infections due to anaerobes.<\/jats:p>","DOI":"10.1136\/pgmj.53.618.195","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"195-200","source":"Crossref","is-referenced-by-count":19,"title":["A new look at erythromycin"],"prefix":"10.1093","volume":"53","author":[{"given":"R W","family":"Lacey","sequence":"first","affiliation":[{"name":"North Cambridgeshire Hospital , Wisbech, Cambridgeshire"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1302\/0301-620X.54B2.299","article-title":"Antibiotics in acute osteomyelitis in children","volume":"54","author":"BLOCKEY, N.J.; MCALLISTER, T.A.","year":"1972","unstructured":"BLOCKEY, N.J. & MCALLISTER, T.A. (1972) Antibiotics in acute osteomyelitis in children. Journal of Bone and Joint Surgery, 54B, 299.","journal-title":"Journal of Bone and Joint Surgery"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1136\/bmj.2.5524.1244","article-title":"Failure of cephaloridine in a case of staphylococcal endocarditis","volume":"3","author":"BURGESS, H.A.; EVANS, K.J.","year":"1966","unstructured":"BURGESS, H.A. & EVANS, K.J. (1966) Failure of cephaloridine in a case of staphylococcal endocarditis. British Medical Journal, 3, 1244.","journal-title":"British Medical Journal"},{"key":"ref_3","first-page":"173","article-title":"Antibiotic and Chemotherapy","author":"GARROD, L.P.; LAMBERT, H.P.; O'GRADY, F.","year":"1973","unstructured":"GARROD, L.P., LAMBERT, H.P. & O'GRADY, F. (1973) Antibiotic and Chemotherapy, pp. 173-174. Churchill Livingstone, Edinburgh and London."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/978-3-642-66062-7_32","volume-title":"Erythromycin and resistance transfer factors in the intestinal tract. In: Drug Inactivating Enzymes and Antibiotic Resistance","author":"GOULD, J.C.","year":"1975","unstructured":"GOULD, J.C. (1975) Erythromycin and resistance transfer factors in the intestinal tract. In: Drug Inactivating Enzymes and Antibiotic Resistance, pp. 259-263. Avicenum, Prague."},{"key":"ref_5","first-page":"209","article-title":"Erythromycin stearate in acute maxillary sinusitis","volume":"7","year":"1976","unstructured":"KALM, O., KAMME, C., BERGSTROM, B., LUFKIST, T. & NORMAN, 0. (1976) Erythromycin stearate in acute maxillary sinusitis. Scandinavian Journal of Infectious Diseases, 7, 209.","journal-title":"Scandinavian Journal of Infectious Diseases"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/jcp.26.12.899","article-title":"Genetic basis, epidemiology and future significance of antibiotic resistance in Staphylococcus aureus","volume":"26","author":"LACEY, R.W.","year":"1973","unstructured":"LACEY, R.W. (1973) Genetic basis, epidemiology and future significance of antibiotic resistance in Staphylococcus aureus. Journal of Clinical Pathology, 26, 899.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_7","article-title":"Lack of evidence for mutation to erythromycin resistance in clinical strains of Staphylococcus aureus","author":"LACEY, R.W.","year":"1976","unstructured":"LACEY, R.W. (1976) Lack of evidence for mutation to erythromycin resistance in clinical strains of Staphylococcus aureus. (In preparation.)"},{"key":"ref_8","article-title":"Inactivation of'penicillinase-resistant' penicillins and cephalosporins by staphylococcal penicillinase; clinical and laboratory studies","volume-title":"Third International Symposium on Staphylococci and Staphylococcal Diseases","author":"LACEY, R.W.; LEWIS, E.L.","year":"1976","unstructured":"LACEY, R.W. & LEWIS, E.L. (1976) Inactivation of'penicillinase-resistant' penicillins and cephalosporins by staphylococcal penicillinase; clinical and laboratory studies. In: Third International Symposium on Staphylococci and Staphylococcal Diseases. Fischer Verlag, Stuttgart."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/bmj.4.5991.243","article-title":"Antibiotic diarrhoea","volume":"4","author":"ARTICLE, L.E.A.D.I.N.G.","year":"1975","unstructured":"LEADING ARTICLE (1975) Antibiotic diarrhoea. British Medical Journal, 4, 243.","journal-title":"British Medical Journal"},{"key":"ref_10","series-title":"Proceedings, Ninth International Congress of Chemotherapy; An","first-page":"439","article-title":"Concentration of antibacterials in human seminal plasma","volume":"216","author":"MALMBORG, A.; DORNBUSCH, K.; ELIASSON, R.; LINDHOLMER, C.","year":"1976","unstructured":"MALMBORG, A., DORNBUSCH, K., ELIASSON, R. & LINDHOLMER, C. (1976) Concentration of antibacterials in human seminal plasma. In: Proceedings, Ninth International Congress of Chemotherapy, July 1975. MANNERS, T.B., GROB, P.R., BENYON, G.P.J. & GIBBS, F.J. (1976) An investigation of antibiotic resistance of Staphylococcus aureus in general practice. Practitioner, 216, 439."},{"key":"ref_11","article-title":"Thymine-requiring bacteria associated with co-trimoxazole therapy","volume":"834","author":"MASKELL, R.; OKUBADEJO, O.A.; PAYNE, R.H.","year":"1976","unstructured":"MASKELL, R., OKUBADEJO, O.A. & PAYNE, R.H. (1976) Thymine-requiring bacteria associated with co-trimoxazole therapy. Lancet, i, 834.","journal-title":"Lancet"},{"key":"ref_12","first-page":"46","article-title":"Antibiotics used in sequence in the treatment of chronic Haemophilus influenzae respiratory infections. In: Clinical Use of Combinations of Antibiotics","volume":"52","author":"MAY, J.R.","year":"1973","unstructured":"MAY, J.R. (1973) Antibiotics used in sequence in the treatment of chronic Haemophilus influenzae respiratory infections. In: Clinical Use of Combinations of Antibiotics. Hodder and Stoughton, London. ORIEL, J.D., REEVE, P., WRIGHT, J. & OWEN, J.M. (1976) Chlamydial infections of the male urethra. British Journal of Venereal Disease, 52, 46.","journal-title":"British Journal of Venereal Disease; Chlamydial infections of the male urethra"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1136\/jcp.28.5.388","article-title":"Antibiotic-disc tests for rapid identification of non-sporing anaerobes","volume":"28","author":"PEACH, S.","year":"1975","unstructured":"PEACH, S. (1975) Antibiotic-disc tests for rapid identification of non-sporing anaerobes. Journal of Clinical Pathology, 28, 388.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/jac\/2.1.71","article-title":"A method of testing the antibiotic susceptibility of Chlamydia trachomatis in a cell culture system","volume":"2","author":"RIDGEWAY, G.L.; OWEN, J.M.; ORIEL, J.D.","year":"1976","unstructured":"RIDGEWAY, G.L., OWEN, J.M. & ORIEL, J.D. (1976) A method of testing the antibiotic susceptibility of Chlamydia trachomatis in a cell culture system. Journal of Antimicrobial Chemotherapy, 2, 71.","journal-title":"Journal of Antimicrobial Chemotherapy"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/618\/195\/50185369\/postgradmedj-53-195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/618\/195\/50185369\/postgradmedj-53-195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T07:06:18Z","timestamp":1683529578000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/53\/618\/195\/7038271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,4,1]]},"references-count":14,"journal-issue":{"issue":"618","published-online":{"date-parts":[[1977,4,1]]},"published-print":{"date-parts":[[1977,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.53.618.195","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1977,4]]},"published":{"date-parts":[[1977,4,1]]}}}