{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:14:03Z","timestamp":1760217243956},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"619","license":[{"start":{"date-parts":[[1977,5,1]],"date-time":"1977-05-01T00:00:00Z","timestamp":231292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The author's experience of fourteen patients with necrotizing fasciitis is reviewed. The pathognomonic feature of this condition is an extensive necrosis of subcutaneous tissue caused by a vicious cycle of infection, local ischaemia and reduced host defence mechanisms. The diagnosis can only be confirmed by immediate exploratory incision.<\/jats:p>\n               <jats:p>The reported mortality of 30-40% reflects the inadaquacy of conservative surgery in the treatment of this serious condition. Mortality can be reduced by early recognition followed by radical excision of the necrotic fascia and overlying skin. The preservation and subsequent use of the excised skin has the advantage of economy in the use of donor areas and reduction in morbidity. Hyperbaric oxygen therapy does not halt the spread of the necrotizing process and is not a substitute for radical surgery.<\/jats:p>","DOI":"10.1136\/pgmj.53.619.237","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"237-242","source":"Crossref","is-referenced-by-count":41,"title":["Necrotizing fasciitis"],"prefix":"10.1093","volume":"53","author":[{"given":"M A","family":"Tehrani","sequence":"first","affiliation":[{"name":"University Department of Surgery, Western Infirmary , Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I M","family":"Ledingham","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Western Infirmary , Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/archderm.1960.01580040083014","article-title":"Progressive fatal cutaneous gangrene associated","volume":"82","author":"ABELE, D.C.; DOBSON, R.L.; NEWSOME, J.F.; LINDBERGER, A.S.","year":"1960","unstructured":"ABELE, D.C., DOBSON, R.L., NEWSOME, J.F. & LINDBERGER, A.S. (1960) Progressive fatal cutaneous gangrene associated with hypogammaglobulinemia. A.M.A. Archives of Dermatology, 82, 565.","journal-title":"Archives of Dermatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1001\/archderm.1970.04000060036009","article-title":"Necrotizing fasciitis due to Group A 3-hemolytic streptococci","volume":"101","author":"BUCHANAN, C.S.; HASERICK, J.R.","year":"1970","unstructured":"BUCHANAN, C.S. & HASERICK, J.R. (1970) Necrotizing fasciitis due to Group A 3-hemolytic streptococci. Archives of Dermatology, 101, 664.","journal-title":"Archives of Dermatology"},{"key":"ref_3","first-page":"148","article-title":"Necrotizing fasciitis","volume":"4","author":"CROSTHWAIT, JR, R.W.; CROSTHWAIT, R.W.; JORDAN, JR, G.L.","year":"1964","unstructured":"CROSTHWAIT, R.W., JR, CROSTHWAIT, R.W. & JORDAN, G.L., JR (1964) Necrotizing fasciitis. Journal of Trauma, 4, 148.","journal-title":"Journal of Trauma"},{"key":"ref_4","first-page":"213","article-title":"Six cases of acute infective gangrene of the extremities","volume":"2","author":"FEDDEN, W.F.","year":"1909","unstructured":"FEDDEN, W.F. (1909) Six cases of acute infective gangrene of the extremities. Proceedings of the Royal Society of IMedicine, 2, 213.","journal-title":"Proceedings of the Royal Society of IMedicine"},{"key":"ref_5","first-page":"439","article-title":"Progressive bacterial synergistic gangrene: chronic undermining ulcer of Meleney","volume":"10","author":"GRAINGER, R.W.; MACKENZIE, D.A.; MCLACHLIN, A.D.","year":"1967","unstructured":"GRAINGER, R.W., MACKENZIE, D.A. & MCLACHLIN, A.D. (1967) Progressive bacterial synergistic gangrene: chronic undermining ulcer of Meleney. 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Journal of Pathology and Bacteriology, 33, 889.","journal-title":"Journal of Pathology and Bacteriology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/bjs.1800620510","article-title":"Diagnosis, clinical course and treatment of acute dermal gangrene","volume":"62","author":"LEDINGHAM, I.McA; TEHRANI, M.A.","year":"1975","unstructured":"LEDINGHAM, I.McA. & TEHRANI, M.A. (1975) Diagnosis, clinical course and treatment of acute dermal gangrene. British Journal of Surgery, 62, 364.","journal-title":"British Journal of Surgery"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/bjs.1800621008","article-title":"Septic shock","volume":"62","author":"LEDINGHAM, I.McA","year":"1975","unstructured":"LEDINGHAM, I.McA. (1975) Septic shock. British Journal of Surgery, 62, 777.","journal-title":"British Journal of Surgery"},{"key":"ref_10","first-page":"1","article-title":"Progressive postoperative gangrene of the skin. Observations on aetiology in two cases","volume":"29","author":"LYALL, A.; STUART, R.D.","year":"1948","unstructured":"LYALL, A. & STUART, R.D. (1948) Progressive postoperative gangrene of the skin. Observations on aetiology in two cases. Glasgow Medical Journal, 29, 1.","journal-title":"Glasgow Medical Journal"},{"key":"ref_11","first-page":"438","article-title":"Suppurative fasciitis as the essential feature of haemolytic streptococcus gangrene with notes on fasciotomy and early wound closure as treatment of choice","volume":"24","author":"MCCAFFERTY, E.L.; LYONS, C.","year":"1948","unstructured":"MCCAFFERTY, E.L. & LYONS, C. (1948) Suppurative fasciitis as the essential feature of haemolytic streptococcus gangrene with notes on fasciotomy and early wound closure as treatment of choice. Surgery, St. Louis, etc., 24, 438.","journal-title":"Surgery, St. Louis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/00000658-196808000-00014","article-title":"Necrotizing infections of subcutaneous tissues and fascia","volume":"168","author":"MEADE, J.W.; MUELLER, C.B.","year":"1968","unstructured":"MEADE, J.W. & MUELLER, C.B. (1968) Necrotizing infections of subcutaneous tissues and fascia. Annals of Surgery, 168, 274.","journal-title":"Annals of Surgery"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1001\/archsurg.1924.01120080083007","article-title":"Hemolytic streptococcus gangrene","volume":"9","author":"MELENEY, F.L.","year":"1924","unstructured":"MELENEY, F.L. (1924) Hemolytic streptococcus gangrene. Archives of Surgery. Chicago, 9, 317.","journal-title":"Archives of Surgery. Chicago"},{"key":"ref_14","article-title":"Hemolytic streptococcus gangrene: importance of early diagnosis and operation","volume":"92","author":"MELENEY, F.L.","year":"1929","unstructured":"MELENEY, F.L. (1929) Hemolytic streptococcus gangrene: importance of early diagnosis and operation. Journal ofthe American Medical Association, 92, 2009.","journal-title":"Journal ofthe American Medical Association"},{"key":"ref_15","first-page":"847","article-title":"Differential diagnosis between certain types of infectious gangrene of the skin","volume":"56","author":"MELENEY, F.L.","year":"1933","unstructured":"MELENEY, F.L. (1933) Differential diagnosis between certain types of infectious gangrene of the skin. Surgery, Gynecology and Obstetrics, 56, 847.","journal-title":"Surgery, Gynecology and Obstetrics"},{"key":"ref_16","first-page":"108","article-title":"Zur kenntnis und Behandlung des nekrotisierenden Erysipels","volume-title":"Deutsche","volume":"144","author":"PFANNER, W.","year":"1918","unstructured":"PFANNER, W. (1918) Zur kenntnis und Behandlung des nekrotisierenden Erysipels. Deutsche Zeitschrift fur Chirurgie, 144, 108."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1097\/00000658-197012000-00005","article-title":"Necrotizing fasciitis","volume":"172","author":"REA, W.J.; WYRICK, W.J.","year":"1970","unstructured":"REA, W.J. & WYRICK, W.J. (1970) Necrotizing fasciitis. Annals of Surgery, 172, 957.","journal-title":"Annals of Surgery"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0002-9378(72)90605-9","article-title":"Progressive synergistic bacterial gangrene arising from abscesses of the vulva and Bartholin's gland duct","volume":"114","author":"ROBERTS, D.B.; HESTER, L.L.","year":"1972","unstructured":"ROBERTS, D.B. & HESTER, L.L. (1972) Progressive synergistic bacterial gangrene arising from abscesses of the vulva and Bartholin's gland duct. 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(1966) Symbiotic gangrene due to Pseudomonas pyocyanea and E. coli. Australian and New Zealand Journal of Surgery, 36, 159.","journal-title":"Australian and New Zealand Journal of Surgery"},{"key":"ref_21","first-page":"416","article-title":"Necrotizing fasciitis","volume":"18","author":"WILSON, B.","year":"1952","unstructured":"WILSON, B. (1952) Necrotizing fasciitis. American Surgeon, 18, 416.","journal-title":"American Surgeon"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1001\/archpedi.1973.04160040087018","article-title":"Acute necrotizing fasciitis in childhood","volume":"125","author":"WILSON, H.D.; HALTALIN, K.","year":"1973","unstructured":"WILSON, H.D. & HALTALIN, K. (1973) Acute necrotizing fasciitis in childhood. American Journal of Diseases of Children, 125, 591.","journal-title":"American Journal of Diseases of Children"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/619\/237\/50185417\/postgradmedj-53-237.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/619\/237\/50185417\/postgradmedj-53-237.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T07:14:17Z","timestamp":1683530057000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/53\/619\/237\/7038235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,5,1]]},"references-count":22,"journal-issue":{"issue":"619","published-online":{"date-parts":[[1977,5,1]]},"published-print":{"date-parts":[[1977,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.53.619.237","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1977,5]]},"published":{"date-parts":[[1977,5,1]]}}}