{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:13:30Z","timestamp":1759335210554},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"619","license":[{"start":{"date-parts":[[1977,5,1]],"date-time":"1977-05-01T00:00:00Z","timestamp":231292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 67-year-old man developed dermatomyositis. Investigation revealed an oat cell carcinoma of the lung. When he developed unilateral gynaecomastia this tumour was found to secrete gonadotrophins. The gynaecomastia disappeared after treatment with an anti-oestrogen\u2014tamoxifen. This use of tamoxifen has not previously been described. Partial tumour regression was obtained with several cytotoxic drug regimes. His dermatomyositis responded to this treatment and remains in remission.<\/jats:p>","DOI":"10.1136\/pgmj.53.619.269","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"269-271","source":"Crossref","is-referenced-by-count":19,"title":["Gynaecomastia associated with gonadotrophin-secreting carcinoma of the lung"],"prefix":"10.1093","volume":"53","author":[{"given":"D","family":"Fairlamb","sequence":"first","affiliation":[{"name":"The Royal Free Hospital , Pond Street, Hampstead, London, NW3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Boesen","sequence":"additional","affiliation":[{"name":"The Royal Free Hospital , Pond Street, Hampstead, London, NW3"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,5,1]]},"reference":[{"key":"ref_1","author":"ARUNDELL, F.D.; WILKINSON, R.D.; HASERICK, J.R.","year":"1960","unstructured":"ARUNDELL, F.D., WILKINSON, R.D. & HASERICK, J.R. 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Archives of Dermatology; Gynecomastia: clinicopathological study of 351 cases"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1210\/jcem-28-6-809","article-title":"Endocrine studies in a patient with gonadotrophin secreting bronchogenic carcinoma","volume":"28","author":"BECKER, K.L.; COTTRELL, J.; MOORE, C.F.; WINNAKER, J.L.; MATTHEWS, M.J.; KATZ, S.","year":"1968","unstructured":"BECKER, K.L., COTTRELL, J., MOORE, C.F., WINNAKER, J.L., MATTHEWS, M.J. & KATZ, S. (1968) Endocrine studies in a patient with gonadotrophin secreting bronchogenic carcinoma. 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(1951) Dermatomyositis as an index of malignant neoplasm: report of case and review of literature. Annals of Internal Medicine, 34, 1269.","journal-title":"Annals of Internal Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/bjc.1971.33","article-title":"A new anti-oestrogenic agent in late breast cancer. A clinical appraisal of","volume":"25","author":"COLE, M.P.; JONES, C.T.A.; TODD, I.D.H.","year":"1971","unstructured":"COLE, M.P., JONES, C.T.A. & TODD, I.D.H. (1971) A new anti-oestrogenic agent in late breast cancer. A clinical appraisal of I.C.I. 46474. British Journal of Cancer, 25, 270.","journal-title":"I. C. I. 46474. 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Lancet, ii, 485.","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.7326\/0003-4819-81-2-182","article-title":"Polymyositis and dermatomyositis: combined methotrexate and corticosteroid therapy","volume":"81","author":"METZGER, A.L.; BOHAN, A.; GOLDBERG, L.S.; BLUESTONE, R.; PEARSON, C.M.","year":"1974","unstructured":"METZGER, A.L., BOHAN, A., GOLDBERG, L.S., BLUESTONE, R. & PEARSON, C.M. (1974) Polymyositis and dermatomyositis: combined methotrexate and corticosteroid therapy. Annals of Internal Medicine, 81, 182.","journal-title":"Annals of Internal Medicine"},{"key":"ref_17","first-page":"448","article-title":"Side Effects of Drugs, Vol. VII. Excepta Medica","volume":"166","author":"MEYLER, L.; HERXHEIMER, A.","year":"1972","unstructured":"MEYLER, L. & HERXHEIMER, A. (Editors) (1972) Side Effects of Drugs, Vol. VII. Excepta Medica, Amsterdam. PRASAD, M.R.N. & SARKARAN, M.S. (1972) Mode of action of non-steroidal anti-oestrogens. Acta endocrinologica (Suppl.), 166, 448.","journal-title":"Acta endocrinologica (Suppl.); Mode of action of non-steroidal anti-oestrogens"},{"key":"ref_18","first-page":"347","article-title":"Gynecomastia associated with vincristine therapy","volume":"107","author":"SMITH, R. M. & BARRETT, 0","year":"1967","unstructured":"SMITH, R.M. & BARRETT, 0. (1967) Gynecomastia associated with vincristine therapy. California Medicine, 107, 347.","journal-title":"California Medicine"},{"key":"ref_19","article-title":"Treatment of corticosteroid-resistant polymyositis with methotrexate","volume":"14","author":"SOKOLOFF, M.C.; GOLDBERG, L.S.; PEARSON, C.M.","year":"1971","unstructured":"SOKOLOFF, M.C., GOLDBERG, L.S. & PEARSON, C.M. (1971) Treatment of corticosteroid-resistant polymyositis with methotrexate. Lancet, i, 14.","journal-title":"Lancet"},{"key":"ref_20","article-title":"Gynecomastia","author":"TREVES, N.","year":"1958","unstructured":"TREVES, N. (1958) Gynecomastia. Cancer, New York, Philadelphia, etc., 11, 1083."},{"key":"ref_21","article-title":"Anti-oestrogen therapy for breast cancer: a trial of tamoxifen at two different dose levels","author":"WARD, H.W.C.","year":"1973","unstructured":"WARD, H.W.C. (1973) Anti-oestrogen therapy for breast cancer: a trial of tamoxifen at two different dose levels."},{"key":"ref_22","first-page":"14","article-title":"British Medical","volume":"1","unstructured":"British Medical Journal, 1, 14.","journal-title":"Journal"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.7326\/0003-4819-50-5-1174","article-title":"Dermatomyositis and malignancy: a review of the literature","volume":"50","author":"WILLIAMS, R.C.","year":"1959","unstructured":"WILLIAMS, R.C. (1959) Dermatomyositis and malignancy: a review of the literature. 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