{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T07:40:54Z","timestamp":1683531654805},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"620","license":[{"start":{"date-parts":[[1977,6,1]],"date-time":"1977-06-01T00:00:00Z","timestamp":233971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A neutropenic child of 20 months suffered generalized infection with Pseudomonas aeruginosa, involving the bloodstream and the meninges. This was successfully treated with intravenous and intrathecal antibiotics and granulocyte transfusions before granulopoiesis recovered spontaneously. No immunoglobulin replacement was given during the acute episode, as the diagnosis of X-linked hypogammaglobulinaemia was made subsequently.<\/jats:p>","DOI":"10.1136\/pgmj.53.620.334","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"334-337","source":"Crossref","is-referenced-by-count":1,"title":["Successful treatment of Pseudomonas aeruginosa septicaemia and meningitis with neutropenia\u2014the presenting feature of hypogammaglobulinaemia"],"prefix":"10.1093","volume":"53","author":[{"given":"P G","family":"Johnston","sequence":"first","affiliation":[{"name":"Departments of Paediatrics and Clinical Bacteriology, Bristol Royal Hospital for Sick Children , St Michael's Hill, Bristol BS2 8BJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D C","family":"Speller","sequence":"additional","affiliation":[{"name":"Departments of Clinical Bacteriology, Bristol Royal Hospital for Sick Children , St Michael's Hill, Bristol BS2 8BJ"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1172\/JCI107804","article-title":"Granulocyte transfusion therapy of experimental Pseudomonas pneumonia","volume":"54","author":"DALE, D.C.; REYNOLDS, H.Y.; PENNINGTON, J.E.; ELIN, R.J.; PITTS, T.W.; GRAW, Jr, R.G.","year":"1974","unstructured":"DALE, D.C., REYNOLDS, H.Y., PENNINGTON, J.E., ELIN, R.J., PITTS, T.W. & GRAW, R.G., Jr (1974) Granulocyte transfusion therapy of experimental Pseudomonas pneumonia. Journal of Clinical Investigation, 54, 664.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_2","first-page":"338","article-title":"Clinical Haematology in Medical Practice","author":"GRUCHY, D.E.; C, G.","year":"1964","unstructured":"DE GRUCHY, G.C. (1964) Clinical Haematology in Medical Practice, 2nd edn, p. 338. Blackwell Scientific Publications, Oxford.","edition":"2nd edn"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1056\/NEJM197208242870801","article-title":"Normal granulocyte transfusion therapy. Treatment of septicemia due to Gram-negative bacteria","volume":"287","author":"GRAW, R.G.; HERZIG, G.; PERRY, S.; HENDERSON, E.S.","year":"1972","unstructured":"GRAW, R.G., HERZIG, G., PERRY, S & HENDERSON, E.S. (1972) Normal granulocyte transfusion therapy. Treatment of septicemia due to Gram-negative bacteria. New England Journal of Medicine, 287, 367.","journal-title":"New England Journal of Medicine"},{"key":"ref_4","first-page":"283","article-title":"Fatal infections in childhood leukemia","volume":"122","author":"HUGHES, W.T.","year":"1971","unstructured":"HUGHES, W.T. (1971) Fatal infections in childhood leukemia. American Journal of Diseases of Childhood, 122, 283.","journal-title":"American Journal of Diseases of Childhood"},{"key":"ref_5","article-title":"Hypogammaglobulinaemia in the United Kingdom. MCR Special Report Series No","author":"COUNCIL, M.E.D.I.C.A.L.R.E.S.E.A.R.C.H.","year":"1971","unstructured":"MEDICAL RESEARCH COUNCIL (1971) Hypogammaglobulinaemia in the United Kingdom. MCR Special Report Series No. 130: London."},{"key":"ref_6","first-page":"375","article-title":"Suppression of granulocyte and platelet production by Pseudomonas burn wound infection","volume":"136","author":"NEWSOME, T.W.; EURENIUS, K.","year":"1973","unstructured":"NEWSOME, T.W. & EURENIUS, K. (1973) Suppression of granulocyte and platelet production by Pseudomonas burn wound infection. Surgery, Gynecology and Obstetrics, 136, 375.","journal-title":"Surgery, Gynecology and Obstetrics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJM197409052911021","article-title":"Intrathecal gentamicin","volume":"291","author":"RAHAL, J.J.; SIMBERKOFF, M.S.; RUBINSTEIN, E.","year":"1974","unstructured":"RAHAL, J.J., SIMBERKOFF, M.S. & RUBINSTEIN, E. (1974) Intrathecal gentamicin. New England Journal of Medicine, 291, 533.","journal-title":"New England Journal of Medicine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM196609292751307","article-title":"The gammaglobulins. III. The antibody deficiency syndromes","volume":"275","author":"ROSEN, F.S.; JANEWAY, C.A.","year":"1966","unstructured":"ROSEN, F.S. & JANEWAY, C.A. (1966) The gammaglobulins. III. The antibody deficiency syndromes. New England Journal of Medicine, 275, 709.","journal-title":"New England Journal of Medicine"},{"key":"ref_9","first-page":"457","article-title":"Rapid microassay of gentamicin, kanamycin, neomycin, streptomycin and vancomycin in serum or plasma","volume":"78","author":"SABATH, L.D.; CASEY, J.I.; RUCH, P.A.; STUMPF, L.L.; FINLAND, M.","year":"1971","unstructured":"SABATH, L.D., CASEY, J.I., RUCH, P.A., STUMPF, L.L. & FINLAND, M. (1971) Rapid microassay of gentamicin, kanamycin, neomycin, streptomycin and vancomycin in serum or plasma. Journal of Laboratory and Clinical Medicine, 78, 457.","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"ref_10","article-title":"Hypogammaglobulinaemia presenting as pseudomonas septicaemia","volume":"710","author":"SPEIRS, C.F.; SELWYN, S.; NICHOLSON, D.N.","year":"1963","unstructured":"SPEIRS, C.F., SELWYN, S. & NICHOLSON, D.N. (1963) Hypogammaglobulinaemia presenting as pseudomonas septicaemia. Lancet, ii, 710.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/ajcp\/63.3.135","article-title":"Successful treatment of Pseudomonas meningitis and septicemia in a leukemic neutropenic adult","volume":"63","author":"TURGEON, P.L.; LAVERDIERE, M.; PERRON, L.","year":"1975","unstructured":"TURGEON, P.L., LAVERDIERE, M. & PERRON, L. (1975) Successful treatment of Pseudomonas meningitis and septicemia in a leukemic neutropenic adult. American Journal of Clinical Pathology, 63, 135.","journal-title":"American Journal of Clinical Pathology"},{"key":"ref_12","first-page":"337","article-title":"Postgraduate Medical Journal","volume":"53","year":"1977","unstructured":"Postgraduate Medical Journal (June 1977) 53, 337-342."},{"key":"ref_13","article-title":"Chronic rhinocerebral phycomycosis in","author":"association with diabetes","unstructured":"Chronic rhinocerebral phycomycosis in association with diabetes"},{"key":"ref_14","article-title":"Phycomycosis is a fungal infection caused by organisms belonging to the class Phycomycetes. Clinical infection with these fungi is found in association with pre-existing diseases such as diabetic ketoacidosis, leukaemia and lymphoma, uraemia, cirrhosis, septic abortion, and treatment with steroids and antibiotics. The infection can present clinically in several localized forms such as rhinocerebral, pulmonary or gastrointestinal, or may be seen in a","volume-title":"Medoff and","author":"form (Abramson, Wilson; Arky, 1967, Battock","year":"1971","unstructured":"Phycomycosis is a fungal infection caused by organisms belonging to the class Phycomycetes. Clinical infection with these fungi is found in association with pre-existing diseases such as diabetic ketoacidosis, leukaemia and lymphoma, uraemia, cirrhosis, septic abortion, and treatment with steroids and antibiotics. The infection can present clinically in several localized forms such as rhinocerebral, pulmonary or gastrointestinal, or may be seen in a disseminated form (Abramson, Wilson and Arky, 1967; Battock et al., 1968; Best et al., 1971; Gass, 1961; Gregory, Golden and Haymaker, 1943; Helderman, Cooper and Mann, 1974; Hoagland et al., 1961; McBride, Corson and Dammin, 1960; Meyer, Rosen and Armstrong, 1972; Medoff and Kobayashi, 1972; Sander et al., 1971; Straatsma, Zimmermal and Gass, 1962; Touche, Sutherland and Telling, 1963; Wasserman, Shields and Sporn, 1961)."},{"key":"ref_15","article-title":"The rhinocerebral form is seen most often in association with diabetic ketoacidosis with","volume-title":"Phycomycosis of the rhinocerebral type usually presents as a progressive disease with a fulminant course. Despite present therapy, death often occurs within a few days to several weeks after","year":"1968","unstructured":"The rhinocerebral form is seen most often in association with diabetic ketoacidosis with 75% of all reported cases having such an association (Battock et al., 1968). Phycomycosis of the rhinocerebral type usually presents as a progressive disease with a fulminant course. Despite present therapy, death often occurs within a few days to several weeks after"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/620\/334\/50185686\/postgradmedj-53-334.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/620\/334\/50185686\/postgradmedj-53-334.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T07:27:07Z","timestamp":1683530827000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/53\/620\/334\/7038414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,6,1]]},"references-count":15,"journal-issue":{"issue":"620","published-online":{"date-parts":[[1977,6,1]]},"published-print":{"date-parts":[[1977,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.53.620.334","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1977,6]]},"published":{"date-parts":[[1977,6,1]]}}}