{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:16:57Z","timestamp":1775085417598,"version":"3.50.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"621","license":[{"start":{"date-parts":[[1977,7,1]],"date-time":"1977-07-01T00:00:00Z","timestamp":236563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,7,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Two cases of lung granulomata associated with \u2018crescentic\u2019 glomerulonephritis both in a clinical setting of polyarteritis nodosa were treated with high doses of intravenous methylprednisolone (\u2018pulse therapy\u2019) in single injections of 30 mg\/kg body-weight. In the first case rapidly progressive glomerulonephritis with 100% crescents was arrested and followed by improvement of renal function from a creatinine clearance of 5 ml\/min to 30 ml\/min; in the second case multiple lung granulomata of 8 months' standing, unresponsive to oral steroids, disappeared 8 days after treatment with high dosage intravenous methylprednisolone.<\/jats:p>\n               <jats:p>The use of \u2018pulse therapy\u2019 with methylprednisolone is advocated, not only in such cases where arteritis is known or suspected, but also in radidly progressive glomerulonephritis associated with crescents.<\/jats:p>","DOI":"10.1136\/pgmj.53.621.382","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"382-387","source":"Crossref","is-referenced-by-count":34,"title":["Methylprednisolone pulse therapy in the treatment of polyarteritis nodosa"],"prefix":"10.1093","volume":"53","author":[{"given":"G H","family":"Neild","sequence":"first","affiliation":[{"name":"Wessex Regional Renal Unit, St Mary's Hospital , Portsmouth"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H A","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Southampton and Wessex Regional Renal Unit , Portsmouth"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,7,1]]},"reference":[{"key":"ref_1","article-title":"Reversal of acute clinical and experimental organ rejection using very large doses of intravenous prednisolone","volume":"876","author":"BELL, P.R.F.; CALMAN, K.C.; WOOD, R.F.M.; BRIGGS, J.D.; PATON, A.M.; MACPHERSON, S.G.","year":"1971","unstructured":"BELL, P.R.F., CALMAN, K.C., WOOD, R.F.M., BRIGGS, J.D., PATON, A.M. & MACPHERSON, S.G. 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