{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T21:56:35Z","timestamp":1753739795923},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"622","license":[{"start":{"date-parts":[[1977,8,1]],"date-time":"1977-08-01T00:00:00Z","timestamp":239241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Five atypical cases were observed amongst ninety children with Perthes' disease, ten of whom had bilateral hip joint involvement. All five were boys, four being under 4 years of age. Four had bilateral hip joint disease, four presented with hip pain, three showing some degree of retardation of bone growth. In one case the hip disorder was familial, and in four there were bony abnormalities elsewhere. Despite the absence of the classic signs of multiple epiphyseal dysplasia, a mild form of this condition is a possible alternative diagnosis for these children. Racial and familial differences are known in the prevalence of Perthes' disease which itself may represent a dysplasia. The pathogenesis of Perthes' disease is still uncertain, although some abnormality of the blood supply to the proximal femoral epiphysis is postulated. That such a vascular defect may be engrafted on to multiple epiphyseal dysplasia is possible, with subsequent joint degeneration which may come to resemble Perthes' disease either clinically or radiologically. A plea is made for the closer study of young children presenting with what may seem to be atypical Perthes' disease.<\/jats:p>","DOI":"10.1136\/pgmj.53.622.464","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"464-472","source":"Crossref","is-referenced-by-count":8,"title":["Perthes' disease and multiple epiphyseal dysplasia"],"prefix":"10.1093","volume":"53","author":[{"given":"H E","family":"Griffiths","sequence":"first","affiliation":[{"name":"Southmead Hospital, Bristol and Royal Hospital for Sick Children , Bristol"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Witherow","sequence":"additional","affiliation":[{"name":"Royal Hospital for Sick Children , Bristol"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1302\/0301-620X.41B3.514","article-title":"Bilateral hereditary micro-epiphyseal dysplasia of the hips","volume":"41","author":"ELSBACH, L.","year":"1959","unstructured":"ELSBACH, L. (1959) Bilateral hereditary micro-epiphyseal dysplasia of the hips. Journal of Bone and Joint Surgery, 41B, 514.","journal-title":"Journal of Bone and Joint Surgery"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/bjs.18003413502","article-title":"Dysplasia epiphysealis mutliplex","volume":"34","author":"FAIRBANK, H.A.T.","year":"1947","unstructured":"FAIRBANK, H.A.T. (1947) Dysplasia epiphysealis mutliplex. British Journal of Surgery, 34, 225.","journal-title":"British Journal of Surgery"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2106\/00004623-197254040-00007","article-title":"An epidemiological study of LeggPerthes disease","volume":"54","author":"FISHER, R.L.","year":"1972","unstructured":"FISHER, R.L. (1972) An epidemiological study of LeggPerthes disease. Journal of Bone and Joint Surgery, 54A, 769.","journal-title":"Journal of Bone and Joint Surgery"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.2106\/00004623-196749080-00014","article-title":"Multiple epiphyseal dysplasia in two siblings: histological and biochemical analysis of epiphyseal plate cartilage in one","volume":"49","author":"HUNT, D.D.; PONSETI, I.V.; PEDRINI-MILLE, A.; PEDRINI, V.","year":"1967","unstructured":"HUNT, D.D., PONSETI, I.V., PEDRINI-MILLE, A. & PEDRINI, V. (1967) Multiple epiphyseal dysplasia in two siblings: histological and biochemical analysis of epiphyseal plate cartilage in one. Journal of Bone and Joint Surgery, 49A, 1611.","journal-title":"Journal of Bone and Joint Surgery"},{"key":"ref_5","article-title":"Skeletal maturation in Perthes disease","author":"JACOBS, P.; HARRISON, M.H.A.; TURNER, M.H.","year":"1974","unstructured":"JACOBS, P., HARRISON, M.H.A. & TURNER, M.H. (1974) Skeletal maturation in Perthes disease. Journal of Bone and Joint Surgery, 56B, 199.","journal-title":"Journal of Bone and Joint Surgery"},{"key":"ref_6","first-page":"18","article-title":"Perthes disease: an experimental and clinical study","volume":"52","author":"KEMP, H.B.S.","year":"1973","unstructured":"KEMP, H.B.S. (1973) Perthes disease: an experimental and clinical study. Annals of the Royal College of Surgeons of England, 52, 18.","journal-title":"Annals of the Royal College of Surgeons of England"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1302\/0301-620X.37B2.228","article-title":"Dysplasia epiphysealis multiplex: a report of fourteen cases in three families","volume":"37","author":"MAUDSLEY, R.H.","year":"1955","unstructured":"MAUDSLEY, R.H. (1955) Dysplasia epiphysealis multiplex: a report of fourteen cases in three families. Journal of Bone and Joint Surgery, 37B, 228.","journal-title":"Journal of Bone and Joint Surgery"},{"key":"ref_8","first-page":"177","article-title":"Pathological histology of the Legg-Calv6-Perthes disease with a special reference to its experimental production","volume":"17","author":"MIzuNo, S.; HIRAYAMA, M.; KOTANI, P.T.; SIMAZU, A.","year":"1966","unstructured":"MIzuNo, S., HIRAYAMA, M., KOTANI, P.T. & SIMAZU, A. (1966) Pathological histology of the Legg-Calv6-Perthes disease with a special reference to its experimental production. Medical Journal of Osaka University, 17, 177.","journal-title":"Medical Journal of Osaka University"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3109\/00016925909171135","article-title":"Hereditary enchondral dysostosis: twelve cases in three generations mainly with peripheral location","volume":"52","author":"ODMAN, P.","year":"1959","unstructured":"ODMAN, P. (1959) Hereditary enchondral dysostosis: twelve cases in three generations mainly with peripheral location. Acta Radiologica, 52, 97.","journal-title":"Acta Radiologica"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/oxfordjournals.jhered.a105605","article-title":"Hereditary LeggCalve-Perthes disease","volume":"37","author":"STEPHENS, F.E.; KERBY, J.P.","year":"1946","unstructured":"STEPHENS, F.E. & KERBY, J.P. (1946) Hereditary LeggCalve-Perthes disease. Journal of Heredity, 37, 153.","journal-title":"Journal of Heredity"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1302\/0301-620X.39B2.358","article-title":"The normal vascular anatomy of the human femoral head during growth","volume":"39","author":"TRUETA, J.","year":"1957","unstructured":"TRUETA, J. (1957) The normal vascular anatomy of the human femoral head during growth. Journal of Bone and Joint Surgery, 39B, 358.","journal-title":"Journal of Bone and Joint Surgery"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1302\/0301-620X.34B1.82","article-title":"Dysplasia epiphysealis multiplex in three sisters","volume":"34","author":"WAUGH, W.","year":"1952","unstructured":"WAUGH, W. (1952) Dysplasia epiphysealis multiplex in three sisters. Journal of Bone and Joint Surgery, 34B, 82.","journal-title":"Journal of Bone and Joint Surgery"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/622\/464\/50202514\/postgradmedj-53-464.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/622\/464\/50202514\/postgradmedj-53-464.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T14:26:07Z","timestamp":1683210367000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/53\/622\/464\/7038467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,8,1]]},"references-count":12,"journal-issue":{"issue":"622","published-online":{"date-parts":[[1977,8,1]]},"published-print":{"date-parts":[[1977,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.53.622.464","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1977,8]]},"published":{"date-parts":[[1977,8,1]]}}}