{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T07:37:16Z","timestamp":1757576236414},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"622","license":[{"start":{"date-parts":[[1977,8,1]],"date-time":"1977-08-01T00:00:00Z","timestamp":239241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Van Buchem disease is a hereditary sclerosing dysplasia of bone. Both dominant and autosomal recessive modes of transmission have been described. The dominant form tends to be a benign disorder and symptoms are usually confined to those associated with the enlargement of the jaw. The recessive forms tend to have a greater morbidity and symptoms arise from pressure on cranial nerves by hyperostotic bone at the base of the skull. Patients of the dominant families have often had a torus palatinus.<\/jats:p>\n               <jats:p>No haematological changes are found. The alkaline phosphatase may be raised\u2014even if the total level is not elevated, the bone fraction may be increased.<\/jats:p>\n               <jats:p>The radiological appearances are regarded as characteristic. The jaw is enlarged and thickened to an extent not seen in other bone dysplasias such as osteopetrosis. The cortices of the diaphyses are thickened and the medullary cavities are encroached upon but not obliterated. Abnormal modelling of the bone ends is not found in van Buchem disease. In long bones the distribution is predominantly diaphyseal but the bone ends are also affected.<\/jats:p>","DOI":"10.1136\/pgmj.53.622.497","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"497-506","source":"Crossref","is-referenced-by-count":14,"title":["Van Buchem disease"],"prefix":"10.1093","volume":"53","author":[{"given":"P","family":"Jacobs","sequence":"first","affiliation":[{"name":"Royal Orthopaedic Hospital , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0007-117X(71)80040-9","article-title":"van Buchem's disease (hyperostosis corticalis generalisata familiaris)","volume":"9","author":"DYSON, D.P.","year":"1972","unstructured":"DYSON, D.P. (1972) van Buchem's disease (hyperostosis corticalis generalisata familiaris), British Journal of Oral Surgery, 9, 237.","journal-title":"British Journal of Oral Surgery"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1148\/90.4.771","article-title":"van Buchem's disease (hyperostosis corticalis generalisata familiaris). A case report","volume":"90","author":"FosMOE, R.J.; HOLM, R.S.; RosCOE, C.H.","year":"1968","unstructured":"FosMOE, R.J., HOLM, R.S. & RosCOE, C.H. (1968) van Buchem's disease (hyperostosis corticalis generalisata familiaris). A case report. Radiology, 90, 771.","journal-title":"Radiology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/bjs.18003714509","article-title":"A rare case of bone dystrophy","volume":"37","author":"HALLIDAY, J.A.","year":"1950","unstructured":"HALLIDAY, J.A. (1950) A rare case of bone dystrophy. British Journal of Surgery, 37, 52.","journal-title":"British Journal of Surgery"},{"key":"ref_4","first-page":"685","article-title":"L'hyperostose corticale generalisee a transmission dominante (Type Worth)","volume":"28","author":"MAROTEAUX, P.; FONTAINE, G.; SCHARFMAN, W.; FARRIAUX, J.P.","year":"1971","unstructured":"MAROTEAUX, P., FONTAINE, G., SCHARFMAN, W. & FARRIAUX, J.P. (1971) L'hyperostose corticale generalisee a transmission dominante (Type Worth). Archives Franfaises de Pe'diatrie, 28, 685.","journal-title":"Archives Franfaises de Pe'diatrie"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1259\/0007-1285-49-578-126","article-title":"van Buchem's disease (hyperostosis corticalis generalisata)","volume":"49","author":"OWEN, R.H.","year":"1976","unstructured":"OWEN, R.H. (1976) van Buchem's disease (hyperostosis corticalis generalisata), British Journal of Radiology, 49, 126.","journal-title":"British Journal of Radiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1259\/0007-1285-47-560-500","article-title":"Hyperostosis corticalis generalisata familiaris","volume":"47","author":"Scorr, W.C.; GAUTBY, T.H.T.","year":"1974","unstructured":"Scorr, W.C. & GAUTBY, T.H.T. (1974) Hyperostosis corticalis generalisata familiaris. British Journal of Radiology, 47, 500.","journal-title":"British Journal of Radiology"},{"key":"ref_7","author":"SPRANGER, J.W.; LANGER, L.O.; WIEDEMANN, H.-R.","year":"1974","unstructured":"SPRANGER, J.W., LANGER, L.O. & WIEDEMANN, H-R. (1974)"},{"issue":"3","key":"ref_8","first-page":"243","article-title":"The pathogenesis of hyperostosis corticalis and calcitonin","volume":"73","author":"Company, Bone Dysplasias W.B.Saunders; BUCHEM, Philadelphia V.A.N.; P, F.S.","year":"1970","unstructured":"Bone Dysplasias. W. B. Saunders Company, Philadelphia. VAN BUCHEM, F.S.P. (1970) The pathogenesis of hyperostosis corticalis and calcitonin. Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series C, Biological and Medical Studies, 73, 3, 243.","journal-title":"Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen, Series C, Biological and Medical Studies"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.0954-6820.1971.tb04373.x","article-title":"Hyperostosis corticalis generalisata. Eight new cases","volume":"189","author":"BUCHEM, V.A.N.; P, F.S.","year":"1971","unstructured":"VAN BUCHEM, F.S.P. (1971) Hyperostosis corticalis generalisata. Eight new cases. Acta medica scandinavica, 189, 257.","journal-title":"Acta medica scandinavica"},{"key":"ref_10","article-title":"Personal communication","author":"BUCHEM, V.A.N.; P, F.S.","year":"1973","unstructured":"VAN BUCHEM, F.S.P. (1973) Personal communication."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0002-9343(62)90235-8","article-title":"Hyperostosis corticalis generalisata. Report of seven cases","volume":"33","author":"WOLDRING, M.G.","year":"1962","unstructured":"WOLDRING, M.G. (1962) Hyperostosis corticalis generalisata. Report of seven cases. American Journal of Medicine, 33, 387.","journal-title":"American Journal of Medicine"},{"key":"ref_12","author":"BUCHEM, V.A.N.; P., F.S.; HADDERS, H.N.; UBBENS, R.","year":"1955","unstructured":"VAN BUCHEM, F.S.P., HADDERS, H.N. & UBBENS, R. (1955)"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1259\/0007-1285-47-564-909-a","article-title":"Hyperostosis corticalis generalisata familiaris (letter)","volume":"47","author":"WATSON, J.A.","year":"1974","unstructured":"WATSON, J.A. (1974) Hyperostosis corticalis generalisata familiaris (letter). British Journal of Radiology, 47, 909.","journal-title":"British Journal of Radiology"},{"key":"ref_14","first-page":"67","article-title":"Hyperostosis corticalis generalisata congenita","volume":"17","author":"WORTH, H.M.; WOLLIN, D.G.","year":"1966","unstructured":"WORTH, H.M. & WOLLIN, D.G. (1966) Hyperostosis corticalis generalisata congenita. Journal of the Canadian Association of Radiologists, 17, 67.","journal-title":"Journal of the Canadian Association of Radiologists"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/622\/497\/50202548\/postgradmedj-53-497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/622\/497\/50202548\/postgradmedj-53-497.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T14:25:53Z","timestamp":1683210353000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/53\/622\/497\/7038440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,8,1]]},"references-count":14,"journal-issue":{"issue":"622","published-online":{"date-parts":[[1977,8,1]]},"published-print":{"date-parts":[[1977,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.53.622.497","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1977,8]]},"published":{"date-parts":[[1977,8,1]]}}}