{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T02:58:01Z","timestamp":1697943481875},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"622","license":[{"start":{"date-parts":[[1977,8,1]],"date-time":"1977-08-01T00:00:00Z","timestamp":239241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Craniofacial dysplasia of a syndromic pattern can usually be classified into one of two easily identifiable groups. In the first group are those malformations of the craniofacial skeleton and soft tissues that are asymmetrical in form and in the other, those that are principally symmetrical. Clinical studies have demonstrated that affected subjects in the symmetrical group frequently improve in terms of facial appearance as growth and development proceed to maturity, while those with asymmetrical defects often deteriorate in this respect. Embryological studies on animal models of these malformations have shown that asymmetrical lateral facial dysplasia and symmetrical mandibulofacial dysplasia exhibit discrete and widely disparate causal mechanisms of malformation. Analysis of these mechanisms and their effects on subsequent growth and development has suggested significant variations in the timing and technique of reconstructive procedures which will enable the surgeon to produce the most effective results when used for the rehabilitation of the afflicted.<\/jats:p>","DOI":"10.1136\/pgmj.53.622.517","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"517-524","source":"Crossref","is-referenced-by-count":4,"title":["The embryological basis of craniofacial dysplasias"],"prefix":"10.1093","volume":"53","author":[{"given":"D E","family":"Poswillo","sequence":"first","affiliation":[{"name":"Department of Teratology, Royal College of Surgeons of England, and Queen Victoria Hospital , East Grinstead"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,8,1]]},"reference":[{"key":"ref_1","first-page":"53","article-title":"In: Developmental Aspects of Oral Biology","author":"JOHNSTON, M.C.; LISTGARTEN, M.","year":"1972","unstructured":"JOHNSTON, M.C. & LISTGARTEN, M. (1972) In: Developmental Aspects of Oral Biology (Ed. by H. C. Slavkin and M. C. Bavetta), p. 53. Academic Press, New York."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/0030-4220(73)90070-4","article-title":"The pathogenesis of the first and second branchial arch syndrome","volume":"35","author":"POSWILLO, D.","year":"1973","unstructured":"POSWILLO, D. (1973) The pathogenesis of the first and second branchial arch syndrome. Oral Surgery, Oral Medicine, Oral Pathology, 35, 302.","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0007-117X(75)90019-0","article-title":"The pathogenesis of the Treacher Collins syndrome","volume":"13","author":"POSWILLO, D.","year":"1975","unstructured":"POSWILLO, D. (1975). The pathogenesis of the Treacher Collins syndrome. British Journal of Oral Surgery, 13, 1.","journal-title":"British Journal of Oral Surgery"},{"issue":"7","key":"ref_4","first-page":"51","article-title":"Lateral facial dysplasia (first and second branchial arch syndrome, hemifacial microsomia)","volume":"11","author":"Ross, R.B.","year":"1975","unstructured":"Ross, R.B. (1975) Lateral facial dysplasia (first and second branchial arch syndrome, hemifacial microsomia). Birth De.fects, 11, 7, 51.","journal-title":"Birth De.fects"},{"key":"ref_5","first-page":"273","article-title":"Osteotomies totales de la face syndrome de Crouzon, syndrome d'Apert","volume":"12","author":"TESSIER, P.","year":"1967","unstructured":"TESSIER, P. (1967). Osteotomies totales de la face syndrome de Crouzon, syndrome d'Apert. Annales de chirurgie plastique, 12, 273.","journal-title":"Annales de chirurgie plastique"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/622\/517\/50202523\/postgradmedj-53-517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/53\/622\/517\/50202523\/postgradmedj-53-517.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T14:26:37Z","timestamp":1683210397000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/53\/622\/517\/7038401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,8,1]]},"references-count":5,"journal-issue":{"issue":"622","published-online":{"date-parts":[[1977,8,1]]},"published-print":{"date-parts":[[1977,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.53.622.517","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1977,8]]},"published":{"date-parts":[[1977,8,1]]}}}