{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:01:24Z","timestamp":1761058884143},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"624","license":[{"start":{"date-parts":[[1977,10,1]],"date-time":"1977-10-01T00:00:00Z","timestamp":244512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1977,10,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A patient with hereditary angio-oedema (HAO) developed mesangiocapillary glomerulonephritis (MCGN) under observation. HAO is characterized by an inherited defect of complement-deficiency of C1 esterase. MCGN is often associated with another complement abnormality which leads to depression of serum C3 and there is some evidence that the complement abnormality precedes the nephritis. The coincidence of these two rare diseases in the present patient, and in one previously described, suggests that other complement abnormalities may predispose to the development of MCGN.<\/jats:p>","DOI":"10.1136\/pgmj.53.624.627","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"627-630","source":"Crossref","is-referenced-by-count":15,"title":["Hereditary angio-oedema with mesangiocapillary glomerulonephritis"],"prefix":"10.1093","volume":"53","author":[{"given":"J","family":"Plaza","sequence":"first","affiliation":[{"name":"University of Newcastle-upon-Tyne , England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Malasit","sequence":"additional","affiliation":[{"name":"University of Newcastle-upon-Tyne , England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D N","family":"Kerr","sequence":"additional","affiliation":[{"name":"University of Newcastle-upon-Tyne , England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.4049\/jimmunol.108.3.837","article-title":"Hereditary C2 deficiency with some manifestations of systemic lupus erythematosus","volume":"108","author":"AGUELLO, V.; BRACCO, D.E.; M., M.; KUNKEL, H.G.","year":"1972","unstructured":"AGUELLO, V., DE BRACCO, M.M., & KUNKEL, H.G. (1972) Hereditary C2 deficiency with some manifestations of systemic lupus erythematosus. Journal of Immunology, 108, 837.","journal-title":"Journal of Immunology"},{"key":"ref_2","author":"ALPER, C.A.; COLTEN, H.R.; ROSEN, F.S.","year":"1972","unstructured":"ALPER, C.A., COLTEN, H.R., & ROSEN, F.S. (1972)"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1056\/NEJM197303222881204","article-title":"Increased susceptibility to infection in a patient with type II essential hypercatabolism of C3","volume":"288","author":"ALPER, C.A.; BLOCH, K.J.; ROSEN, F.S.","year":"1973","unstructured":"ALPER, C.A., BLOCH, K.J. & ROSEN, F.S. (1973) Increased susceptibility to infection in a patient with type II essential hypercatabolism of C3. 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Factors governing the ability of circulating complexes to localize in blood vessels. Journal of Experimental Medicine, 127, 137.","journal-title":"Journal of Experimental Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0002-9343(63)90162-1","article-title":"A biochemical abnormality in hereditary angioneurotic oedema: absence of serum inhibitor of Cl esterase","volume":"35","author":"DONALDSON, V.H.; EVANS, R.R.","year":"1963","unstructured":"DONALDSON, V.H. & EVANS, R.R. (1963). A biochemical abnormality in hereditary angioneurotic oedema: absence of serum inhibitor of Cl esterase. American Journal of Medicine, 35, 37.","journal-title":"American Journal of Medicine"},{"key":"ref_7","first-page":"2","article-title":"Hereditary angioedema: a review with particular reference to pathogenesis and treatment","volume":"1","author":"HADJIYANNAKI, K.; LACHMANN, P.J.","year":"1971","unstructured":"HADJIYANNAKI, K., & LACHMANN, P.J. (1971) Hereditary angioedema: a review with particular reference to pathogenesis and treatment. Clinical Allergy, 1, 2.","journal-title":"Clinical Allergy"},{"key":"ref_8","author":"HAUPTMANN, G.; GROSSHANs, E.; HEID, E.","unstructured":"HAUPTMANN, G., GROSSHANs, E. & HEID, E. (In press)"},{"key":"ref_9","first-page":"107","article-title":"Systemic lupus erythematosus and hereditary complement deficiencies. A case with total C4 deficiency. Annales de Dermatologie et","volume":"16","author":"de Syphiligraphie HENSON; M, P.","year":"1969","unstructured":"Systemic lupus erythematosus and hereditary complement deficiencies. A case with total C4 deficiency. Annales de Dermatologie et de Syphiligraphie HENSON, P.M. (1969) The adherence of leucocyte and platelets induced by fixed IgG antibody or complement. Immunology, 16, 107.","journal-title":"Immunology; The adherence of leucocyte and platelets induced by fixed IgG antibody or complement"},{"key":"ref_10","first-page":"76","article-title":"Some clinical aspects of hereditary angioedema (HAE)","volume":"12","author":"HOLTI, G.","year":"1975","unstructured":"HOLTI G. (1975) Some clinical aspects of hereditary angioedema (HAE). (Abstract.) Biorheology, 12, 76.","journal-title":"(Abstract.) Biorheology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJM197203302861304","article-title":"Lupus erythematosus-like syndrome with a familial defect of complement","volume":"286","author":"MONCADA, B.; NOORBIBI, K.B.; GOOD, R.A.; WHINDHORST, D.B.","year":"1972","unstructured":"MONCADA, B., NOORBIBI, K.B., GOOD, R.A. & WHINDHORST, D.B. (1972) Lupus erythematosus-like syndrome with a familial defect of complement. New England Journal of Medicine, 286, 689.","journal-title":"New England Journal of Medicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ki.1976.6","article-title":"Classical complement pathway activation in membranoproliferative glomerulonephritis","volume":"9","author":"M., Y.; VALLOTA, E.H.; WEST, C.D.","year":"1976","unstructured":", Y.M., VALLOTA, E.H., WEST, C.D. (1976) Classical complement pathway activation in membranoproliferative glomerulonephritis. Kidney International, 9, 46.","journal-title":"Kidney International"},{"key":"ref_13","article-title":"Mesangiocapillary nephritis, partial lipodystrophy and hypocomplementaemia","volume":"535","author":"PETERS, D.K.; WILLIAMS, D.G.; CHARLESWORTH, J.A.; JONES, B.O.U.L.T.O.N.; M., J.; SISSON, J.G.P.; EVANS, D.J.","year":"1973","unstructured":"PETERS, D.K., WILLIAMS, D.G., CHARLESWORTH, J.A., BOULTON JONES, J.M., SISSON, J.G.P. & EVANS, D.J. 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Journal of Pediatrics, 78, 30.","journal-title":"Journal of Pediatrics"},{"key":"ref_15","first-page":"73","article-title":"Mesangiocapillary glomerulonephritis with dense 'deposits' in the basement membranes of the kidney","volume":"5","author":"VARGAS, R.; THOMSON, K.J.; WILSON, D.; CAMERON, J.S.; TURNER, D.R.; GILL, D.; CHANTLER, C.; OGG, C.S.","year":"1976","unstructured":"VARGAS, R., THOMSON, K.J., WILSON, D., CAMERON, J.S., TURNER, D.R., GILL, D., CHANTLER, C. & OGG, C.S. (1976) Mesangiocapillary glomerulonephritis with dense 'deposits' in the basement membranes of the kidney. Clinical Nephrology, 5, 73.","journal-title":"Clinical Nephrology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1172\/JCI105027","article-title":"Serum levels of Beta ic globulin, a complement component in the nephritides, lipoid nephrosis and other conditions","volume":"43","author":"WEST, C.D.; NORTHWAY, J.D.; DAVIS, N.C.","year":"1964","unstructured":"WEST, C.D., NORTHWAY, J.D. & DAVIS, N.C. (1964) Serum levels of Beta ic globulin, a complement component in the nephritides, lipoid nephrosis and other conditions. 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