{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:29:47Z","timestamp":1759541387325},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"627","license":[{"start":{"date-parts":[[1978,1,1]],"date-time":"1978-01-01T00:00:00Z","timestamp":252460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1978,1,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A case of Whipple's disease in a female is described. Malabsorption of iron, vitamin B12, folic acid and fat was present. These abnormalities reverted to normal after introduction of co-trimoxazole therapy. The patient's humoral immune system was normal, in contrast to impairment of cell-mediated immunity, which has not improved in spite of co-trimoxazole treatment for 2 years, and a therapeutic trial of levamisole.<\/jats:p><jats:p>These findings are further evidence that there may be a primary immune deficiency in patients with Whipple's disease.<\/jats:p>","DOI":"10.1136\/pgmj.54.627.45","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"45-50","source":"Crossref","is-referenced-by-count":16,"title":["Whipple's disease in a female with impaired cell-mediated immunity unresponsive to co-trimoxazole and levamisole therapy"],"prefix":"10.1093","volume":"54","author":[{"given":"M R","family":"Haeney","sequence":"first","affiliation":[{"name":"Metabolic Unit, East Birmingham Hospital , Birmingham B9 5ST"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I N","family":"Ross","sequence":"additional","affiliation":[{"name":"Metabolic Unit, East Birmingham Hospital , Birmingham B9 5ST"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1978,1,1]]},"reference":[{"key":"ref_1","first-page":"650","article-title":"Agammaglobulinemia complicating Whipple's disease-Case Report","volume":"57","author":"ANTON, A.T.","year":"1961","unstructured":"ANTON, A.T. 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