{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:13:56Z","timestamp":1760645636468},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"628","license":[{"start":{"date-parts":[[1978,2,1]],"date-time":"1978-02-01T00:00:00Z","timestamp":255139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1978,2,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Two cases of severe metabolic alkalosis associated with gastric hypersecretion were successfully treated with dilute hydrochloric acid and a histamine H2-receptor antagonist given by intravenous infusion. This combined therapy with electrolyte replacement and suppression of gastric secretion is valuable in the control of this serious metabolic abnormality when conventional treatment is unsuccessful or contraindicated.<\/jats:p>","DOI":"10.1136\/pgmj.54.628.118","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"118-123","source":"Crossref","is-referenced-by-count":11,"title":["The use of dilute hydrochloric acid and cimetidine to reverse severe metabolic alkalosis"],"prefix":"10.1093","volume":"54","author":[{"given":"B J","family":"Rowlands","sequence":"first","affiliation":[{"name":"Department of Surgery and Anaesthetics, Northern General Hospital , Sheffield, S5 7AU"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S F","family":"Tindall","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anaesthetics, Northern General Hospital , Sheffield, S5 7AU"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D J","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anaesthetics, Northern General Hospital , Sheffield, S5 7AU"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1978,2,1]]},"reference":[{"key":"ref_1","first-page":"194","article-title":"Intravenous infusion of hydrochloric acid for treatment of severe metabolic acidosis","volume":"75","author":"ABOUNA, G.M.; VEASEY, P.R.; TERRY, D.B.","year":"1974","unstructured":"ABOUNA, G.M., VEASEY, P.R. & TERRY, D.B. (1974) Intravenous infusion of hydrochloric acid for treatment of severe metabolic acidosis. Surgery, 75, 194.","journal-title":"Surgery"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1136\/pgmj.47.549.516","article-title":"Metabolic alkalosis treated with intravenous hydrochloric acid","volume":"47","author":"BEACH, F.X.M.; JONES, E.S.","year":"1971","unstructured":"BEACH, F.X.M. & JONES, E.S. (1971) Metabolic alkalosis treated with intravenous hydrochloric acid. Postgraduate Medical Journal, 47, 516.","journal-title":"Postgraduate Medical Journal"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0140-6736(76)92342-4","article-title":"Cimetidine in the treatment of active duodenal and prepyloric ulcers","volume":"ii,","author":"BODEMAR, G.; WALAM, A.","year":"1976","unstructured":"BODEMAR, G. & WALAM, A. (1976) Cimetidine in the treatment of active duodenal and prepyloric ulcers. Lancet, ii, 161.","journal-title":"Lancet"},{"key":"ref_4","series-title":"Cimetidine. Proceedings of the Second International Symposium, Royal College of Physicians","first-page":"337","article-title":"Treatment of upper gastrointestinal haemorrhage with cimetidine","author":"DYKES, P.W.; KANG, J.Y.; HOARE, A.; HAWKINS, C.F.; MILLS, J.G.","year":"1977","unstructured":"DYKES, P.W., KANG, J.Y., HOARE, A., HAWKINS, C.F. & MILLS, J.G. (1977) Treatment of upper gastrointestinal haemorrhage with cimetidine. In: Cimetidine. Proceedings of the Second International Symposium, Royal College of Physicians (Ed. by W. L. Burland & M. A. Simkins), p. 337. Excerpta Medica, Amsterdam and Oxford."},{"key":"ref_5","article-title":"Hydrochloric acid for metabolic alkalosis","volume":"720","author":"E.D.I.T.O.R.I.A.L.","year":"1974","unstructured":"EDITORIAL (1974) Hydrochloric acid for metabolic alkalosis. Lancet, i, 720.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"308","DOI":"10.2337\/diab.21.5.308","article-title":"The glycaemic response to arginine in man","volume":"21","author":"FELIG, P.; MARLISS, E.","year":"1972","unstructured":"FELIG, P. & MARLISS, E. (1972) The glycaemic response to arginine in man. Diabetes, 21, 308.","journal-title":"Diabetes"},{"key":"ref_7","first-page":"151","article-title":"The effect of cimetidine, a histamine-H2 antagonist on gastric acid and intrinsic factor secretion during pentagastrin infusion","volume":"63","author":"FIELDING, L.P.; CHALMERs, D.M.; STAFFORD, D.M.; LEVI, J.","year":"1976","unstructured":"FIELDING, L.P., CHALMERs, D.M., STAFFORD, D.M. & LEVI, J. (1976) The effect of cimetidine, a histamine-H2 antagonist on gastric acid and intrinsic factor secretion during pentagastrin infusion. British Journal of Surgery, 63, 151.","journal-title":"British Journal of Surgery"},{"key":"ref_8","first-page":"1924","article-title":"The treatment of severe metabolic alkalosis with intravenous NI1O or N\/5 hydrochloric acid","volume":"88","author":"FRICK, P.G.; SENNING, A.","year":"1963","unstructured":"FRICK, P.G. & SENNING, A. (1963) The treatment of severe metabolic alkalosis with intravenous NI1O or N\/5 hydrochloric acid. Deutsche medizinische Wochenschrift, 88, 1924.","journal-title":"Deutsche medizinische Wochenschrift"},{"key":"ref_9","article-title":"Treatment of duodenal ulcer with cimetidine","volume":"983","author":"HAGGIE, S.J.; FERMONT, D.C.; WYLLIE, J.H.","year":"1976","unstructured":"HAGGIE, S.J., FERMONT, D.C. & WYLLIE, J.H. (1976) Treatment of duodenal ulcer with cimetidine. Lancet, i, 983.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/archsurg.1975.01360130051010","article-title":"Hydrochloric acid in the correction of metabolic alkalosis","volume":"110","author":"HARKEN, A.H.; GABEL, R.A.; FENEL, V.; MOORE, F.D.","year":"1975","unstructured":"HARKEN, A.H., GABEL, R.A., FENEL, V. & MOORE, F.D. (1975). Hydrochloric acid in the correction of metabolic alkalosis. Archives of Surgery, 110, 819.","journal-title":"Archives of Surgery"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1001\/archinte.1972.03650050096020","article-title":"Arginine-induced hyperkalemia in renal failure patients","volume":"130","author":"HERTZ, P.; RICHARDSON, J.A.","year":"1972","unstructured":"HERTZ, P. & RICHARDSON, J.A. (1972) Arginine-induced hyperkalemia in renal failure patients. Archives of Internal Medicine, 130, 778.","journal-title":"Archives of Internal Medicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1056\/NEJM197410102911506","article-title":"Serious acid-base disorders","volume":"291","author":"KASSIRER, J.P.","year":"1974","unstructured":"KASSIRER, J.P. (1974) Serious acid-base disorders. New England Journal of Medicine, 291, 773.","journal-title":"New England Journal of Medicine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0002-9343(65)90172-5","article-title":"The critical role of chloride in the correction of hypokalemia alkalosis in man","volume":"38","author":"KASSIRER, J.P.; BERKMAN, P.M.; LAWRENZ, D.R.","year":"1965","unstructured":"KASSIRER, J.P., BERKMAN, P.M. & LAWRENZ, D.R. (1965) The critical role of chloride in the correction of hypokalemia alkalosis in man. American Journal of Medicine, 38, 172.","journal-title":"American Journal of Medicine"},{"key":"ref_14","article-title":"H2-receptor antagonists and antacids in the prevention of acute gastrointestinal haemorrhage in fulminant hepatic failure - two controlled trials","volume":"617","author":"MACDOUGALL, B.R.D.; BAILEY, R.J.; WILLIAMS, R.","year":"1977","unstructured":"MACDOUGALL, B.R.D., BAILEY, R.J. & WILLIAMS, R. (1977) H2-receptor antagonists and antacids in the prevention of acute gastrointestinal haemorrhage in fulminant hepatic failure - two controlled trials. Lancet, i, 617.","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1136\/bmj.2.6049.1445","article-title":"Cimetidine and ulcers","volume":"2","author":"MISIEWICZ, J.J.; BURLAND, W.L.","year":"1976","unstructured":"MISIEWICZ, J.J. & BURLAND, W.L. (1976) Cimetidine and ulcers. (Correspondence.) British Medical Journal, 2, 1445.","journal-title":"(Correspondence.) British Medical Journal"},{"key":"ref_16","article-title":"Healing of gastric ulcer during treatment with cimetidine","volume":"337","author":"POUNDER, R.E.; HUNT, R.H.; STEKELMAN, M.; MILTONTHOMPSON, G.J.; MISIEWICZ, J.J.","year":"1976","unstructured":"POUNDER, R.E., HUNT, R.H., STEKELMAN, M., MILTONTHOMPSON, G.J. & MISIEWICZ, J.J. (1976) Healing of gastric ulcer during treatment with cimetidine. Lancet, i, 337.","journal-title":"Lancet"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0039-6109(16)41030-3","article-title":"Fluid, electrolyte and acid-base balance","volume":"56","author":"RANDALL, H.T.","year":"1976","unstructured":"RANDALL, H.T. (1976) Fluid, electrolyte and acid-base balance. Surgical Clinics of North America, 56, 1019.","journal-title":"Surgical Clinics of North America"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1056\/NEJM196809192791204","article-title":"Role of anions in metabolic alkalosis and potassium deficiency","volume":"279","author":"SCHWARTZ, W.B.; STRIHOU, V.A.N.Y.P.E.R.S.E.L.E.D.E.; C.; KASSIRER, J.P.","year":"1968","unstructured":"SCHWARTZ, W.B., VAN YPERSELE DE STRIHOU, C. & KASSIRER, J.P. (1968) Role of anions in metabolic alkalosis and potassium deficiency. New England Journal of Medicine, 279, 630.","journal-title":"New England Journal of Medicine"},{"key":"ref_19","first-page":"439","article-title":"Postoperative metabolic alkalosis and acute renal failure: rationale for the use of hydrochloric acid","volume":"78","author":"SHAVELLE, H.S.; PARKE, R.","year":"1975","unstructured":"SHAVELLE, H.S. & PARKE, R. (1975) Postoperative metabolic alkalosis and acute renal failure: rationale for the use of hydrochloric acid. Surgery, 78, 439.","journal-title":"Surgery"},{"key":"ref_20","series-title":"Cimetidine. Proceedings of the Second International Symposium, Royal College of Physicians","first-page":"306","article-title":"Treatment of Zollinger-Ellison patients with cimetidine","author":"STAGE, J.G.; RUNE, S.J.; STADIL, F.; WORNING, H.","year":"1977","unstructured":"STAGE, J.G., RUNE, S.J., STADIL, F. & WORNING, H. (1977) Treatment of Zollinger-Ellison patients with cimetidine. In: Cimetidine. Proceedings of the Second International Symposium, Royal College of Physicians (Ed. by W. L. Burland & M. A. Simkins), p. 306. Excerpta Medica, Amsterdam and Oxford."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1136\/bmj.1.6019.1189","article-title":"Hydrogen ion infusion for treating severe metabolic alkalosis","volume":"1","author":"WILLIAMS, S.E.","year":"1976","unstructured":"WILLIAMS, S.E. (1976) Hydrogen ion infusion for treating severe metabolic alkalosis. British Medical Journal, 1, 1189.","journal-title":"British Medical Journal"},{"key":"ref_22","first-page":"123","article-title":"Postgraduate Medical Journal","volume":"54","year":"1978","unstructured":"Postgraduate Medical Journal (February 1978) 54, 123-126."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/54\/628\/118\/50158441\/postgradmedj-54-118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/54\/628\/118\/50158441\/postgradmedj-54-118.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T08:07:31Z","timestamp":1683533251000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/54\/628\/118\/7063140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,2,1]]},"references-count":22,"journal-issue":{"issue":"628","published-online":{"date-parts":[[1978,2,1]]},"published-print":{"date-parts":[[1978,2,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.54.628.118","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1978,2]]},"published":{"date-parts":[[1978,2,1]]}}}