{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T18:21:23Z","timestamp":1699294883364},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"630","license":[{"start":{"date-parts":[[1978,4,1]],"date-time":"1978-04-01T00:00:00Z","timestamp":260236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1978,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A case of neutropenia in an infant is described, associated with repeated minor infections which responded to treatment with antibiotics. A granulocyte agglutinin was detected in the serum. Following treatment with prednisolone the neutropenia remitted, the antibody disappeared and the infections ceased. Treatment was discontinued after three months and the child remained well five months later. Reports of similar cases are reviewed and the significance of the antibody discussed.<\/jats:p>","DOI":"10.1136\/pgmj.54.630.278","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"278-280","source":"Crossref","is-referenced-by-count":3,"title":["Auto-immune neutropenia in an infant"],"prefix":"10.1093","volume":"54","author":[{"given":"D S","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Haematology, Whittington Hospital , London N19"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Stableforth","sequence":"additional","affiliation":[{"name":"Department of Haematology, Whittington Hospital , London N19"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Darlow","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Whittington Hospital , London N19"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"Brazier","sequence":"additional","affiliation":[{"name":"Medical Research Council Blood Group Reference Laboratory , Gatliff Road, London SW1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1978,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1056\/NEJM197510092931505","article-title":"Autoimmune neutropenia","volume":"293","author":"BOXER, L.A.; GREENBERG, M.S.; BOXER, G.J.; STOSSEL, T.P.","year":"1975","unstructured":"BOXER, L.A., GREENBERG, M.S., BOXER, G.J. & STOSSEL, T.P. (1975) Autoimmune neutropenia. New England Journal of Medicine, 293, 748.","journal-title":"New England Journal of Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1172\/JCI107704","article-title":"Effects of anti-human neutrophil antibodies in vitro","volume":"53","author":"BOXER, L.A.; STOSSEL, T.P.","year":"1974","unstructured":"BOXER, L.A. & STOSSEL, T.P. (1974) Effects of anti-human neutrophil antibodies in vitro. Journal of Clinical Investigation, 53, 1534.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_3","first-page":"783","article-title":"Isoimmune neonatal neutropenia","volume":"80","author":"BOXER, L.A.; YOKOYAMA, M.; LALEZARI, P.","year":"1972","unstructured":"BOXER, L.A., YOKOYAMA, M. & LALEZARI, P. (1972) Isoimmune neonatal neutropenia. Journal of Pediatrics, 80, 783.","journal-title":"Journal of Pediatrics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM197501302920503","article-title":"Quantitative determination of antibody in idiopathic thrombocytopenic purpura","volume":"292","author":"DIXON, R.; ROSSE, W.; EBBERT, L.","year":"1975","unstructured":"DIXON, R., ROSSE, W. & EBBERT, L. (1975) Quantitative determination of antibody in idiopathic thrombocytopenic purpura. New England Journal of Medicine, 292, 230.","journal-title":"New England Journal of Medicine"},{"key":"ref_5","first-page":"334","article-title":"Cytotoxic antibodies against leucocytes. Vox sanguinis","volume":"11","author":"ENGELFRIET, C.P.; BRIrrEN, A.","year":"1966","unstructured":"ENGELFRIET, C.P. & BRIrrEN, A. (1966) Cytotoxic antibodies against leucocytes. Vox sanguinis. Basel, 11, 334.","journal-title":"Basel"},{"key":"ref_6","first-page":"58","article-title":"Studies on the occurrence of leucocyte-antibodies. Vox sanguinis","volume":"3","author":"GOUDSMIT, R.; LOGHEM, V.A.N.; J, J.","year":"1953","unstructured":"GOUDSMIT, R. & VAN LOGHEM, J.J. (1953) Studies on the occurrence of leucocyte-antibodies. Vox sanguinis. Amsterdam, 3, 58.","journal-title":"Amsterdam"},{"key":"ref_7","first-page":"1205","article-title":"Letter","volume":"ii,","author":"KAUFMAN, D.B.","year":"1975","unstructured":"KAUFMAN, D.B. (1975) Letter. Lancet, ii, 1205.","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2141.1976.tb00948.x","article-title":"Leucocyte function in a case of chronic benign neutropenia of infancy associated with circulating leucoagglutinins","volume":"32","author":"KAY, A.B.; WHITE, A.G.; BARCLAY, G.R.; DARG, C.; RAEBURN, J.A.; UTTLEY, W.S.; MCCRAE, W.M.; INNES, E.M.","year":"1976","unstructured":"KAY, A.B., WHITE, A.G., BARCLAY, G.R., DARG, C., RAEBURN, J.A., UTTLEY, W.S., MCCRAE, W.M. & INNES, E.M. (1976) Leucocyte function in a case of chronic benign neutropenia of infancy associated with circulating leucoagglutinins. British Journal of Haematology, 32, 451.","journal-title":"British Journal of Haematology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1056\/NEJM197510092931504","article-title":"Chronic autoimmune neutropenia due to anti-NA2 antibody","volume":"293","author":"LALEZARI, P.; JIANG, A.F.; YEGEN, L.; SANTORINEOU, M.","year":"1975","unstructured":"LALEZARI, P., JIANG, A.F., YEGEN, L. & SANTORINEOU, M. (1975) Chronic autoimmune neutropenia due to anti-NA2 antibody. New England Journal of Medicine, 293, 744.","journal-title":"New England Journal of Medicine"},{"key":"ref_10","first-page":"281","article-title":"Neutrophil specific antigens: Immunology and clinical significance","volume":"11","author":"LALEZARI, P.; RADEL, E.","year":"1974","unstructured":"LALEZARI, P. & RADEL, E. (1974) Neutrophil specific antigens: Immunology and clinical significance. Seminars in Haematology, 11, 281.","journal-title":"Seminars in Haematology"},{"key":"ref_11","article-title":"Immune neutropenia","volume":"24","author":"ARTICLE, L.E.A.D.I.N.G.","year":"1976","unstructured":"LEADING ARTICLE (1976) Immune neutropenia. Lancet, i, 24.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0022-3476(75)80596-8","article-title":"Autoimmune neutropenia in an infant","volume":"87","author":"NEPO, A.G.; GUNAY, U.; BOXER, L.A.; HONIG, G.R.","year":"1975","unstructured":"NEPO, A.G., GUNAY, U., BOXER, L.A. & HONIG, G.R. (1975) Autoimmune neutropenia in an infant. Journal of Pediatrics, 87, 251.","journal-title":"Journal of Pediatrics"},{"key":"ref_13","first-page":"203","article-title":"The incidence and significance of complete and incomplete white cell antibodies with special reference to the use of the Coombs consumption test. Vox sanguinis","volume":"3","author":"LOGHEM, V.A.N.; J., J.; HART, V.A.N.D.E.R.; M., H.I.J.M.A.N.S.; W.; SCHUIT, H.R.E.","year":"1958","unstructured":"VAN LOGHEM, J.J., VAN DER HART, M., HIJMANS, W. & SCHUIT, H.R.E. (1958) The incidence and significance of complete and incomplete white cell antibodies with special reference to the use of the Coombs consumption test. Vox sanguinis. Basel, 3, 203.","journal-title":"Basel"},{"key":"ref_14","first-page":"280","article-title":"Postgraduate Medical Journal","volume":"54","year":"1978","unstructured":"Postgraduate Medical Journal (April 1978) 54, 280-281."},{"key":"ref_15","article-title":"Summary A case of pituitary coma with continuing menstruation is presented. This association is extremely rare, but a history of recent menstrual periods does not exclude advanced hypopituitarism from the differential diagnosis of severe hyponatraemia","unstructured":"Summary A case of pituitary coma with continuing menstruation is presented. This association is extremely rare, but a history of recent menstrual periods does not exclude advanced hypopituitarism from the differential diagnosis of severe hyponatraemia."},{"key":"ref_16","article-title":"Introduction The pattern of hormone deficiency in pituitary failure is variable and the occurrence of deficiencies of single hormones is well recognized","volume-title":"Although menstrual cycles and even pregnancy are known to occur in patients with partial hypopituitarism (Simpson, 1959), gonadotrophin loss is usually an early if not the first feature of most patients with hypopituitarism (Sheehan, 1939). This is a report of a patient, presenting with coma due to advanced pituitary failure, who was still menstruating","year":"1974","unstructured":"Introduction The pattern of hormone deficiency in pituitary failure is variable and the occurrence of deficiencies of single hormones is well recognized (Hall, 1974). Although menstrual cycles and even pregnancy are known to occur in patients with partial hypopituitarism (Simpson, 1959), gonadotrophin loss is usually an early if not the first feature of most patients with hypopituitarism (Sheehan, 1939). This is a report of a patient, presenting with coma due to advanced pituitary failure, who was still menstruating."},{"key":"ref_17","article-title":"A 50-year-old housewife was admitted to hospital in July 1976 48 hr after an episode of unconsciousness lasting several hours from which she had made a spontaneous recovery. A previous attack had occurred in September 1975. Following both attacks, which were unrelated to fasting, she had noticed a dull frontal headache and sweating. After the first attack, she had been seen in out-patients and found to have a fasting blood sugar of 2-7 mmol\/l (43 mg\/dl) with normal plasma electrolytes. She had felt generally unwell since the death of her husband 4 years previously, and for 2 years had noticed increasing lethargy","unstructured":"A 50-year-old housewife was admitted to hospital in July 1976 48 hr after an episode of unconsciousness lasting several hours from which she had made a spontaneous recovery. A previous attack had occurred in September 1975. Following both attacks, which were unrelated to fasting, she had noticed a dull frontal headache and sweating. After the first attack, she had been seen in out-patients and found to have a fasting blood sugar of 2-7 mmol\/l (43 mg\/dl) with normal plasma electrolytes. She had felt generally unwell since the death of her husband 4 years previously, and for 2 years had noticed increasing lethargy."},{"key":"ref_18","article-title":"She had had normal pregnancies and had lactated normally over 24 and 16 years previously. She had been under regular review in gynaecological outpatients for vaginal prolapse since 1973 and there is a well documented account of her menstrual history. During the 12 months before admission she had had","unstructured":"She had had normal pregnancies and had lactated normally over 24 and 16 years previously. She had been under regular review in gynaecological outpatients for vaginal prolapse since 1973 and there is a well documented account of her menstrual history. During the 12 months before admission she had had"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/54\/630\/278\/50158759\/postgradmedj-54-278.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/54\/630\/278\/50158759\/postgradmedj-54-278.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T08:16:55Z","timestamp":1683533815000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/54\/630\/278\/7063179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,4,1]]},"references-count":18,"journal-issue":{"issue":"630","published-online":{"date-parts":[[1978,4,1]]},"published-print":{"date-parts":[[1978,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.54.630.278","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1978,4]]},"published":{"date-parts":[[1978,4,1]]}}}