{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:56:46Z","timestamp":1757699806795},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"635","license":[{"start":{"date-parts":[[1978,9,1]],"date-time":"1978-09-01T00:00:00Z","timestamp":273456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1978,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A well documented sporadic case of multiple endocrine adenomatosis (MEA) type I, with the pituitary tumour presenting as a prolactinoma, is described in a 28-year-old female. Primary amenorrhoea, resulting from hyperprolactinaemia, was the first symptom of the polyglandular neoplasia. A gastrinoma was removed from the head of the pancreas and latent hyperparathyroidism appeared to be present. Treatment with bromocriptine was poorly tolerated; neurosurgical intervention was refused by the patient. The possibility that a serum prolactin determination may be useful in detecting pituitary involvement in MEA deserves consideration.<\/jats:p>","DOI":"10.1136\/pgmj.54.635.618","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"618-622","source":"Crossref","is-referenced-by-count":9,"title":["A case of multiple endocrine adenomatosis with primary amenorrhoea"],"prefix":"10.1093","volume":"54","author":[{"given":"M","family":"Vandeweghe","sequence":"first","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Academical Hospital , Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Braxel","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Academical Hospital , Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Schutyser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kliniek Maria's Voorzienigheid , Kortrijk, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Academical Hospital , Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1978,9,1]]},"reference":[{"key":"ref_1","article-title":"Occurrence of other endocrine tumours in primary hyperparathyroidism","volume":"781","author":"TAYLOR, S.","year":"1975","unstructured":"& TAYLOR, S. (1975) Occurrence of other endocrine tumours in primary hyperparathyroidism. Lancet, ii, 781.","journal-title":"Lancet"},{"key":"ref_2","first-page":"353","article-title":"Multiple endocrine adenomatosis with metabolic myopathy","volume":"1","author":"BOUILLON, R.; KONINCKX, P.; MOOR, D.E.; P.","year":"1974","unstructured":"BOUILLON, R., KONINCKX, P. & DE MOOR, P. (1974) In: Radioimmunoassay and Related Procedures in Medicine, vol. 1, p. 353. International Atomic Energy Agency, Vienna. CAUGHEY, J.E., PARENDEH, G., COHEN, L.B. & VAMEGHI, M. (1971) Multiple endocrine adenomatosis with metabolic myopathy. New Zealand Medical Journal, 74, 28.","journal-title":"Radioimmunoassay and Related Procedures in Medicine; New Zealand Medical Journal"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1136\/bmj.1.5958.604","article-title":"Prolactin studies in 'functionless' pituitary tumours","volume":"1","author":"CHILD, D.F.; NADER, S.; MASHITER, K.; KJELD, M.; BANKS, L.; FRASER, R.T.","year":"1975","unstructured":"CHILD, D.F., NADER, S., MASHITER, K., KJELD, M., BANKS, L. & FRASER, R.T. (1975) Prolactin studies in 'functionless' pituitary tumours. British Medical Journal, 1, 604.","journal-title":"British Medical Journal"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1210\/jcem-42-5-857","article-title":"Human mixed somatotrophic and lactotrophic pituitary adenomas","volume":"42","author":"CORENBLUM, B.; SIREK, A.M.T.; HORVATH, E.; KOVAcs, K.; EzRIN, C.","year":"1976","unstructured":"CORENBLUM, B., SIREK, A.M.T., HORVATH, E., KOVAcs, K. & EzRIN, C. (1976) Human mixed somatotrophic and lactotrophic pituitary adenomas. Journal of Clinical Endocrinology and Metabolism, 42, 857.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_5","first-page":"494","article-title":"L'ad6nomatose polyendocrinienne (Syndrome de Wermer); A propos d'une observation personelle; Revue de la litt6rature. Semaine des h6pitaux de","volume":"47","author":"CROISIER, J.C.; AZERAD, E.; LUBETZKI, J.","year":"1971","unstructured":"CROISIER, J.C., AZERAD, E. & LUBETZKI, J. (1971) L'ad6nomatose polyendocrinienne (Syndrome de Wermer); A propos d'une observation personelle; Revue de la litt6rature. Semaine des h6pitaux de Paris, 47, 494.","journal-title":"Paris"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/0002-9343(72)90059-9","article-title":"Glucagonoma as apart ofthe polyglandular adenoma syndrome","volume":"52","author":"CROUGHS, R.J.M.; HULSMANS, H.A.M.; ISRAEL, D.E.; HACKENG, W.H.L.; SCHOPMAN, W.","year":"1972","unstructured":"CROUGHS, R.J.M., HULSMANS, H.A.M., ISRAEL, D.E., HACKENG, W.H.L. & SCHOPMAN, W. (1972) Glucagonoma as apart ofthe polyglandular adenoma syndrome. American Journal of Medicine, 52, 690.","journal-title":"American Journal of Medicine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1056\/NEJM197610212951711","article-title":"Prolactin and amenor-rhea","volume":"295","author":"E.D.I.T.O.R.I.A.L.","year":"1976","unstructured":"EDITORIAL (1976) Prolactin and amenor-rhea. New England Journal of Medicine, 295, 954.","journal-title":"New England Journal of Medicine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/bmj.3.5768.225","article-title":"Plasma prolactin activity in inappropriate lactation","volume":"3","author":"FORSYTH, I.A.; BESSER, G.M.; EDWARDS, C.R.W.; FRANCIS, L.; MYRES, R.P.","year":"1971","unstructured":"FORSYTH, I.A., BESSER, G.M., EDWARDS, C.R.W., FRANCIS, L. & MYRES, R.P. (1971) Plasma prolactin activity in inappropriate lactation. British Medical Journal, 3, 225.","journal-title":"British Medical Journal"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0002-9378(16)33789-9","article-title":"Current understanding of human prolactin physiology and its diagnostic and therapeutic applications: a review","volume":"118","author":"FOURNIER, P.J.R.; DESJARDINS, P.D.; FRIESEN, H.G.","year":"1974","unstructured":"FOURNIER, P.J.R., DESJARDINS, P.D. & FRIESEN, H.G. (1974) Current understanding of human prolactin physiology and its diagnostic and therapeutic applications: a review. American Journal of Obstetrics and Gynecology, 118, 337.","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"ref_10","first-page":"55","article-title":"Studies of prolactin secretion in pituitary disease","volume":"67","author":"FRANKS, S.; JACOBS, H.S.; NABARRO, J.D.N.","year":"1975","unstructured":"FRANKS, S., JACOBS, H.S. & NABARRO, J.D.N. (1975) Studies of prolactin secretion in pituitary disease. Journal of Endocrinology, 67, 55P.","journal-title":"Journal of Endocrinology"},{"key":"ref_11","first-page":"41","article-title":"Pituitary prolactinomas. Incidence in 56 patients with chromophobe adenoma: clinical features, treatment. Abstracts of the Vth International Congress of Endocrinology","author":"FRANKS, S.F.; JACOBS, H.S.; NABARRO, J.D.N.","year":"1976","unstructured":"FRANKS, S.F., JACOBS, H.S. & NABARRO, J.D.N. (1976) Pituitary prolactinomas. Incidence in 56 patients with chromophobe adenoma: clinical features, treatment. Abstracts of the Vth International Congress of Endocrinology, Hamburg, p. 41."},{"key":"ref_12","first-page":"273","volume-title":"International Symposium on Human Prolactin; Excerpta Medica, Amsterdam.","author":"FRANTZ, A.G.; HABIF, D.V.; HYMAN, G.A.; SUH, H.K.; SASSIN, I.F.; ZIMMERMAN, E.A.; NOEL, G.L.; KLEINBERG, D.L.","year":"1973","unstructured":"FRANTZ, A.G., HABIF, D.V., HYMAN, G.A., SUH, H.K., SASSIN, I.F., ZIMMERMAN, E.A., NOEL, G.L. & KLEINBERG, D.L. (1973) In: Pasteels, J.L. & Robijn, C. (Eds) International Symposium on Human Prolactin, p. 273. Excerpta Medica, Amsterdam."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0025-7125(16)32067-3","article-title":"Clinical aspects of gastrin physiology","volume":"58","author":"HANSKY, J.","year":"1974","unstructured":"HANSKY, J. (1974) Clinical aspects of gastrin physiology. Medical Clinics of North America, 58, 1217.","journal-title":"Medical Clinics of North America"},{"key":"ref_14","author":"JACOBS, H.S.; DAUGHADAY, W.","year":"1973","unstructured":"JACOBS, H.S. & DAUGHADAY, W. (1973) In: Pasteels, & L.J."},{"key":"ref_15","first-page":"189","volume-title":"International Symposium on Human Prolactin; Excerpta Medica, Amsterdam.","author":"Robijn, C.","unstructured":"Robijn, C. (Eds) International Symposium on Human Prolactin, p. 189. Excerpta Medica, Amsterdam."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1365-2265.1976.tb01974.x","article-title":"Clinical and endocrine features of hyperprolactinaemic amenorrhoea","volume":"5","author":"JACOBS, H.S.; FRANKS, S.; MURRAY, M.A.F.; HULL, M.G.R.; STEELE, S.J.; NABARRO, J.D.N.","year":"1976","unstructured":"JACOBS, H.S., FRANKS, S., MURRAY, M.A.F., HULL, M.G.R., STEELE, S.J. & NABARRO, J.D.N. (1976) Clinical and endocrine features of hyperprolactinaemic amenorrhoea. Clinical Endocrinology, 5, 439.","journal-title":"Clinical Endocrinology"},{"key":"ref_17","first-page":"179","article-title":"Multiple endocrine adenomatosis","volume":"31","author":"KOLODNY, H.D.; GRIBOFF, S.I.","year":"1964","unstructured":"KOLODNY, H.D. & GRIBOFF, S.I. (1964) Multiple endocrine adenomatosis. Journal of the Mount Sinai Hospital, 31, 179.","journal-title":"Journal of the Mount Sinai Hospital"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1001\/archinte.1976.03630010028005","article-title":"Pituitary tumours and hyperprolactinemia","volume":"136","author":"MALARKEY, W.B.; JOHNSON, J.C.","year":"1976","unstructured":"MALARKEY, W.B. & JOHNSON, J.C. (1976) Pituitary tumours and hyperprolactinemia. Archives of Internal Medicine, 136, 40.","journal-title":"Archives of Internal Medicine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0016-5085(19)35152-2","article-title":"Zollinger-Ellison syndrome in a Bantu woman, with isolation of gastrin-like substance from the primary and secondary tumors","volume":"41","author":"MARKS, I.N.; SELZER, G.; Louw, J.H.; BANK, S.","year":"1961","unstructured":"MARKS, I.N., SELZER, G., Louw, J.H. & BANK, S. (1961) Zollinger-Ellison syndrome in a Bantu woman, with isolation of gastrin-like substance from the primary and secondary tumors. Gastroenterology, 41, 77.","journal-title":"Gastroenterology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/jcp.15.4.374","article-title":"A simple fluorimetric method for the estimation of free 1 1-hydroxycorticoids in human plasma","volume":"15","author":"MATTINGLY, D.","year":"1962","unstructured":"MATTINGLY, D. (1962) A simple fluorimetric method for the estimation of free 1 1-hydroxycorticoids in human plasma. Journal of Clinical Pathology, 15, 374.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1210\/jcem-43-6-1398","article-title":"Ovarian refractoriness to gonadotrophins in cases of inappropriate lactation: restoration of ovarian function with bromocriptine","volume":"43","author":"MROUEH, A.M.; SILER-KHODR, T.M.","year":"1976","unstructured":"MROUEH, A.M. & SILER-KHODR, T.M. (1976) Ovarian refractoriness to gonadotrophins in cases of inappropriate lactation: restoration of ovarian function with bromocriptine. Journal of Clinical Endocrinology and Metabolism, 43, 1398.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0039-6109(16)40286-0","article-title":"Multiple endocrine adenomatosis","volume":"54","author":"NEWSOME, H.H.","year":"1974","unstructured":"NEWSOME, H.H. (1974) Multiple endocrine adenomatosis. Surgical Clinics of North America, 54, 387.","journal-title":"Surgical Clinics of North America"},{"key":"ref_23","first-page":"1383","article-title":"Ultrastructural, histologic and hormonal characterization of a prolactin-rich human pituitary tumour","volume":"39","author":"PEAKE, G.T.; MCKEEL, D.W.; JARETT, L.; DAUGHADAY, W.H.","year":"1969","unstructured":"PEAKE, G.T., MCKEEL, D.W., JARETT, L. & DAUGHADAY, W.H. (1969) Ultrastructural, histologic and hormonal characterization of a prolactin-rich human pituitary tumour. Journal of Clinical Endocrinology and Metabolism, 39, 1383.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.7326\/0003-4819-76-1-53","article-title":"Five families with multiple endocrine adenomatosis","volume":"76","year":"1972","unstructured":"SNYDER, N., SCURRY, M.T. & DE1Ss JR, W.P. (1972) Five families with multiple endocrine adenomatosis. Annals of Internal Medicine, 76, 53.","journal-title":"Annals of Internal Medicine"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2265.1976.tb01979.x","article-title":"Acromegaly caused by pulmonary carcinoid tumours","volume":"5","author":"SONKSEN, P.H.; AYREs, A.B.; BRAIMBRIDGE, M.; CORRIN, B.; DAVIES, D.R.; JEREMIAH, G.M.; OATEN, S.W.; LOWY, C.; WEST, T.E.T.","year":"1976","unstructured":"SONKSEN, P.H., AYREs, A.B., BRAIMBRIDGE, M., CORRIN, B., DAVIES, D.R., JEREMIAH, G.M., OATEN, S.W., LOWY, C. & WEST, T.E.T. (1976) Acromegaly caused by pulmonary carcinoid tumours. Clinical Endocrinology, 5, 503.","journal-title":"Clinical Endocrinology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0039-6109(16)40583-9","article-title":"Gastrinomas","volume":"55","author":"STREMPLE, J.F.","year":"1975","unstructured":"STREMPLE, J.F. (1975) Gastrinomas. Surgical Clinics of North America, 55, 303.","journal-title":"Surgical Clinics of North America"},{"key":"ref_27","article-title":"Hyperprolactinemia asso ciated with empty sella syndrome","volume":"235","author":"TAH-HSIUNG, H.; SHAPIRO, J.R.; TYSON, J.E.; LEDDY, A.L.; PAz-GuEvARA, A.T.","year":"1976","unstructured":"TAH-HSIUNG, H., SHAPIRO, J.R., TYSON, J.E., LEDDY, A.L. & PAz-GuEvARA, A.T. (1976) Hyperprolactinemia asso ciated with empty sella syndrome. Journal of the American Medical Association, 235, 2002.","journal-title":"Journal of the American Medical Association"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/00000658-197209000-00014","article-title":"Effect of secretin on circulating gastrin","volume":"176","author":"THOMPSON, J.C.; REEDER, D.D.; BUNCHMAN, H.H.; BECKER, H.D.; BRANDT, E.N.","year":"1972","unstructured":"THOMPSON, J.C., REEDER, D.D., BUNCHMAN, H.H., BECKER, H.D. & BRANDT, E.N. (1972) Effect of secretin on circulating gastrin. Annals of Surgery, 176, 384.","journal-title":"Annals of Surgery"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0002-9378(16)33651-1","article-title":"Prolactin secretion in 65 patients with galactorrhea","volume":"118","author":"TOLIS, G.; SommA, M.; CAMPENHOUT, V.A.N.; J.; FRIESEN, H.","year":"1974","unstructured":"TOLIS, G., SommA, M., VAN CAMPENHOUT, J. & FRIESEN, H. (1974) Prolactin secretion in 65 patients with galactorrhea. American Journal of Obstetrics and Gynecology, 118, 91.","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"ref_30","first-page":"465","article-title":"Polyad6nomatose endocrinienne associant un ad6nome hypophysaire a prolactine et un ad6nome parathyroldien intrathyroldien. Annales d'Endocrinologie","volume":"37","author":"TOURNIARE, J.; TROUILLAS, J.; MAILLET, P.; DAVID, L.; PALLO, D.; MINH, T.R.A.N.; V.; BRESSOT, C.","year":"1976","unstructured":"TOURNIARE, J., TROUILLAS, J., MAILLET, P., DAVID, L., PALLO, D., TRAN MINH, V. & BRESSOT, C. (1976) Polyad6nomatose endocrinienne associant un ad6nome hypophysaire a prolactine et un ad6nome parathyroldien intrathyroldien. Annales d'Endocrinologie. Paris, 37, 465.","journal-title":"Paris"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0002-9343(72)90071-X","article-title":"Familial nesidioblastosis as the predominant manifestation of multiple endocrine adenomatosis","volume":"52","author":"VANCE, J.E.; STOLL, R.W.; KITABCHI, A.E.; BUCHANAN, K.D.; HOLLANDER, D.; WILLIAMS, R.H.","year":"1972","unstructured":"VANCE, J.E., STOLL, R.W., KITABCHI, A.E., BUCHANAN, K.D., HOLLANDER, D. & WILLIAMS, R.H. (1972) Familial nesidioblastosis as the predominant manifestation of multiple endocrine adenomatosis. American Journal of Medicine, 52, 211.","journal-title":"American Journal of Medicine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-4731(76)90156-4","article-title":"Radioimmunoassay of 17,3-hydroxy, 5a-androstan-3-one,4-androstene-3,17, dehydroepiandrosterone, 1 7-hydroxy-progesterone and progesterone and its application to human male plasma","volume":"7","author":"VERMEULEN, A.; VERDONCK, L.","year":"1976","unstructured":"VERMEULEN, A. & VERDONCK, L. (1976) Radioimmunoassay of 17,3-hydroxy, 5a-androstan-3-one,4-androstene-3,17, dehydroepiandrosterone, 1 7-hydroxy-progesterone and progesterone and its application to human male plasma. Journal of Steroid Biochemistry, 7, 1.","journal-title":"Journal of Steroid Biochemistry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0002-9343(54)90353-8","article-title":"Genetic aspects of adenomatosis of endocrine glands","volume":"16","author":"WERMER, P.","year":"1954","unstructured":"WERMER, P. (1954) Genetic aspects of adenomatosis of endocrine glands. American Journal of Medicine, 16, 363.","journal-title":"American Journal of Medicine"},{"key":"ref_34","first-page":"205","article-title":"Endocrine adenomatosis and peptic ulcer in a large kindred","volume":"35","author":"WERMER, P.","year":"1963","unstructured":"WERMER, P. (1963) Endocrine adenomatosis and peptic ulcer in a large kindred. American Journal ofMedicine, 35, 205.","journal-title":"American Journal ofMedicine"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0300-5089(21)00082-1","article-title":"Multiple endocrine adenomatosis; multiple hormone-producing tumours, a familial syndrome","volume":"3","author":"WERMER, P.","year":"1974","unstructured":"WERMER, P. (1974) Multiple endocrine adenomatosis; multiple hormone-producing tumours, a familial syndrome. Clinics in Gastroenterology, 3, 671.","journal-title":"Clinics in Gastroenterology"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/54\/635\/618\/50158933\/postgradmedj-54-618.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/54\/635\/618\/50158933\/postgradmedj-54-618.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T08:31:18Z","timestamp":1683534678000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/54\/635\/618\/7063571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,9,1]]},"references-count":35,"journal-issue":{"issue":"635","published-online":{"date-parts":[[1978,9,1]]},"published-print":{"date-parts":[[1978,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.54.635.618","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1978,9]]},"published":{"date-parts":[[1978,9,1]]}}}