{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:14:23Z","timestamp":1788174863061,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"643","license":[{"start":{"date-parts":[[1979,5,1]],"date-time":"1979-05-01T00:00:00Z","timestamp":294364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1979,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Coagulation problems in pregnancy are primarily associated with overactivity of the intrinsic clotting system. This accounts for the increased incidence of thrombo-embolism during pregnancy. Where specific obstetric complications cause clotting problems the common underlying feature is usually placental pathology as in abruptio placentae, pre-eclampsia or hydatidiform mole.<\/jats:p>\n               <jats:p>Abnormal activation of the clotting system is an early, and occasionally the first detectable feature of pre-eclampsia, but there is no evidence that this is a primary change. Therefore the role of anticoagulant treatment in the management of pre-eclampsia remains questionable. A new test for estimating factor VIII consumption is proving to be a sensitive index of early activation of the clotting system and can be used for the diagnosis of early pre-eclampsia.<\/jats:p>","DOI":"10.1136\/pgmj.55.643.367","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"367-371","source":"Crossref","is-referenced-by-count":18,"title":["Coagulation problems in human pregnancy"],"prefix":"10.1093","volume":"55","author":[{"given":"C W","family":"Redman","sequence":"first","affiliation":[{"name":"Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital , Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1979,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1136\/bmj.1.6115.756-a","article-title":"Recurrent abruptio placentae treated with the fibrinolytic inhibitor tranexamic acid","volume":"1","author":"ASTEDT, B.; NILSSON, I.M.","year":"1978","unstructured":"ASTEDT, B. & NILSSON, I.M. 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