{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:11:53Z","timestamp":1761765113061},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"644","license":[{"start":{"date-parts":[[1979,6,1]],"date-time":"1979-06-01T00:00:00Z","timestamp":297043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1979,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Two Iraqi sisters and a female cousin developed diabetes insipidus (DI), diabetes mellitus (DM), optic atrophy (OA), and deafness (D), (the \u2018DIDMOAD\u2019 syndrome) before the age of 12 years. One girl exhibited all the features of this disease complex only 3 months after an unusually late onset of recognizable symptoms at 11 years 9 months. Another girl died suddenly and unexpectedly. This family study illustrates the recessive inheritance pattern of the syndrome.<\/jats:p>","DOI":"10.1136\/pgmj.55.644.377","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"377-380","source":"Crossref","is-referenced-by-count":10,"title":["Diabetes insipidus, diabetes mellitus, optic atrophy and deafness. A clinical and genetic study"],"prefix":"10.1093","volume":"55","author":[{"given":"N A","family":"Nagi","sequence":"first","affiliation":[{"name":"College of Medicine, University of Mosul , Mosul, Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1979,6,1]]},"reference":[{"key":"ref_1","article-title":"On the Use of the Ophthalmoscope in Diseases of the Nervous System and of the Kidneys, Also in Certain other General Disorders","author":"ALLBUTT, T.C.","year":"1871","unstructured":"ALLBUTT, T.C. (1871) On the Use of the Ophthalmoscope in Diseases of the Nervous System and of the Kidneys, Also in Certain other General Disorders. MacMillan & Co.. London & New York."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0022-5347(17)64559-2","article-title":"Nephrogenic diabetes insipidus accompanied by massive dilatation of the kidneys, ureters and bladder","volume":"89","author":"CARTER, R.D.; GOODMAN, A.D.","year":"1963","unstructured":"CARTER, R.D. & GOODMAN, A.D. (1963) Nephrogenic diabetes insipidus accompanied by massive dilatation of the kidneys, ureters and bladder. Journal of Urology, 89, 366.","journal-title":"Journal of Urology"},{"key":"ref_3","first-page":"320","article-title":"The relation of spinal cord disease to gynecomastia and testicular atrophy","volume":"25","author":"S, C.A.R.T.Y.C.","year":"1950","unstructured":"CARTY. C.S. (1950) The relation of spinal cord disease to gynecomastia and testicular atrophy. Proceedings. Mayo Clinic, 25, 320.","journal-title":"Proceedings. Mayo Clinic"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1530\/acta.0.0650095","article-title":"Association of juvenile diabetes mellitus, primary optic atrophy and perceptive hearing loss in three sibs, with additional idiopathic diabetes mellitus insipidus in one case","volume":"65","author":"PETROCHILOS, M.","year":"1970","unstructured":"PETROCHILOS, M. (1970) Association of juvenile diabetes mellitus, primary optic atrophy and perceptive hearing loss in three sibs, with additional idiopathic diabetes mellitus insipidus in one case. Acta endocrinologica, 65, 95.","journal-title":"Acta endocrinologica"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1001\/archinte.1974.00320190034003","article-title":"Diabetes mellitus and optic atrophy","volume":"134","author":"MARQUARDT, J.L.; LORIAUX, L.","year":"1974","unstructured":"MARQUARDT, J.L. & LORIAUX, L. (1974) Diabetes mellitus and optic atrophy. Archives of Internal Medicine, 134, 32.","journal-title":"Archives of Internal Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1177\/003591577106400716","article-title":"Juvenile diabetes mellitus, diabetes insipidus and neurological abnormalities","volume":"64","author":"MOORE, J.R.","year":"1971","unstructured":"MOORE, J.R. (1971) Juvenile diabetes mellitus, diabetes insipidus and neurological abnormalities, Proceedings of tlhe Royal Society of Medicine, 64, 730.","journal-title":"Proceedings of tlhe Royal Society of Medicine"},{"key":"ref_7","first-page":"366","article-title":"Mendelian Inheritance in Man","author":"A, McKUSICK V.","year":"1971","unstructured":"McKUSICK. V.A. (1971) Mendelian Inheritance in Man. 3rd edn, p. 366. Johns Hopkins Press, Baltimore & London.","edition":"3rd edn"},{"key":"ref_8","first-page":"505","article-title":"The syndrome of diabetes insipidus, diabetes mellitus, optic atrophy and deafness","volume":"45","author":"PAGE, M.McB; ASMAL, A.C.; EDWARDS, C.R.W.","year":"1976","unstructured":"PAGE, M. McB., ASMAL, A.C. & EDWARDS, C.R.W. (1976) The syndrome of diabetes insipidus, diabetes mellitus, optic atrophy and deafness. Quarterly Journal of Medicine, 45, 505.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1136\/bmj.2.5373.1625","article-title":"Diabetes mellitus and insipidus in two sisters","volume":"2","author":"RAITI, S.; PLOTKIN, S.; NEWNS, G.H.","year":"1963","unstructured":"RAITI, S., PLOTKIN, S. & NEWNS, G.H. (1963) Diabetes mellitus and insipidus in two sisters. British Medical Journal, 2, 1625.","journal-title":"British Medical Journal"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/adc.52.10.796","article-title":"Diabetes insipidus, diabetes mellitus, optic atrophy and deafness: 3 cases of 'DIDMOAD' syndrome","volume":"52","author":"RICHARDSON, J.E.; HAMILTON, W.","year":"1977","unstructured":"RICHARDSON, J.E. & HAMILTON, W. (1977) Diabetes insipidus, diabetes mellitus, optic atrophy and deafness: 3 cases of 'DIDMOAD' syndrome. Archives of Disease in Childhood, 52, 796.","journal-title":"Archives of Disease in Childhood"},{"key":"ref_11","first-page":"385","article-title":"The association of juvenile diabetes mellitus and optic atrophy; clinical and genetical aspects","volume":"35","author":"ROSE, F.C.; FRASER, G.R.; FRIEDMAN, A.I.; KOHNER, E.M.","year":"1966","unstructured":"ROSE, F.C., FRASER, G.R., FRIEDMAN, A.I. & KOHNER, E.M. (1966) The association of juvenile diabetes mellitus and optic atrophy; clinical and genetical aspects. Quarterly Journal of Medicine, 35, 385.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/jnnp.21.1.47","article-title":"Optic atrophy and nerve deafness in diabetes mellitus","volume":"21","author":"SHAW, D.A.; DUNCAN, L.J.","year":"1958","unstructured":"SHAW, D.A. & DUNCAN, L.J. (1958) Optic atrophy and nerve deafness in diabetes mellitus. Journal of Neurology, Neurosurgery and Psychiatry, 21, 47.","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0022-3476(70)80012-9","article-title":"Progressive hydronephrosis, hydroureter and dilatation of the bladder in siblings with congenital nephrogenic diabetes insipidus","volume":"77","author":"BENSEL, T.E.N.; W., R.; PETERS, E.R.","year":"1970","unstructured":"TEN BENSEL, R.W. & PETERS, E.R. (1970) Progressive hydronephrosis, hydroureter and dilatation of the bladder in siblings with congenital nephrogenic diabetes insipidus. Journal of Pediatrics, 77, 439.","journal-title":"Journal of Pediatrics"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0022-5347(17)63888-6","article-title":"Pituitary diabetes indipidus associated with progressive urinary tract dilatation","volume":"92","author":"WHEELER, J.S.; ADELSON, W.J.","year":"1964","unstructured":"WHEELER, J.S. & ADELSON, W.J. (1964) Pituitary diabetes indipidus associated with progressive urinary tract dilatation. Journal of Urology, 92, 64.","journal-title":"Journal of Urology"},{"key":"ref_15","first-page":"715","article-title":"Diabetes mellitus and simple optic atrophy among siblings","volume":"13","author":"WOLFRAM, D.J.; WAGENER, H.P.","year":"1938","unstructured":"WOLFRAM, D.J. & WAGENER, H.P. (1938) Diabetes mellitus and simple optic atrophy among siblings. Proceedings. Mayo Clinic. 13. 715.","journal-title":"Proceedings. Mayo Clinic"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/55\/644\/377\/50159564\/postgradmedj-55-377.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/55\/644\/377\/50159564\/postgradmedj-55-377.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T09:10:52Z","timestamp":1683537052000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/55\/644\/377\/7063750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,6,1]]},"references-count":15,"journal-issue":{"issue":"644","published-online":{"date-parts":[[1979,6,1]]},"published-print":{"date-parts":[[1979,6,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.55.644.377","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1979,6]]},"published":{"date-parts":[[1979,6,1]]}}}