{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:23:59Z","timestamp":1760189039489},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"644","license":[{"start":{"date-parts":[[1979,6,1]],"date-time":"1979-06-01T00:00:00Z","timestamp":297043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1979,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Twenty-five patients with healed gastric ulcers completed an 11-month double-blind controlled trial comparing cimetidine 1 g daily with placebo in the prevention of ulcer relapse. Ulcers recurred in 14 patients, 12 on placebo, 2 on cimetidine. In 11 patients, 9 on cimetidine, 2 on placebo, the ulcers remained healed at the end of the trial (P &amp;lt; 0.002).<\/jats:p>\n               <jats:p>Cimetidine 1 g daily significantly reduces the relapse rate in gastric ulceration.<\/jats:p>","DOI":"10.1136\/pgmj.55.644.393","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"393-395","source":"Crossref","is-referenced-by-count":35,"title":["Cimetidine in the prevention of gastric ulcer relapse"],"prefix":"10.1093","volume":"55","author":[{"given":"R J","family":"Machell","sequence":"first","affiliation":[{"name":"Department of Medical Gastroenterology, Addenbrooke's Hospital , Cambridge"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Ciclitira","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, Addenbrooke's Hospital , Cambridge"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J G","family":"Farthing","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, Addenbrooke's Hospital , Cambridge"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P","family":"Dick","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, Addenbrooke's Hospital , Cambridge"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J O","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, Addenbrooke's Hospital , Cambridge"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1979,6,1]]},"reference":[{"key":"ref_1","first-page":"533","article-title":"A study of the factors influencing mortality rates from gastro-intestinal haemorrhage","volume":"180","author":"ALLAN, R.; DYKES, P.","year":"1976","unstructured":"ALLAN, R. & DYKES, P. (1976) A study of the factors influencing mortality rates from gastro-intestinal haemorrhage. Quarterly Journal of Medicine, 180, 533.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_2","article-title":"Cimetidine in duodenal ulcer","volume":"174","author":"BLACKWOOD, W.S.; MAUDGAL, D.P.; PICKARD, R.G.; LAWRENCE, D.; NORTHFIELD, T.C.","year":"1976","unstructured":"BLACKWOOD, W.S., MAUDGAL, D.P., PICKARD, R.G., LAWRENCE, D. & NORTHFIELD, T.C. (1976) Cimetidine in duodenal ulcer. Lancet, ii, 174.","journal-title":"Lancet"},{"key":"ref_3","article-title":"Prevention by bedtime cimetidine of duodenal ulcer relapse","volume":"626","author":"BLACKWOOD, W.S.; MAUDGAL, D.P.; NORTHFIELD, T.C.","year":"1978","unstructured":"BLACKWOOD, W.S., MAUDGAL, D.P. & NORTHFIELD, T.C. (1978) Prevention by bedtime cimetidine of duodenal ulcer relapse. Lancet, i, 626.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0140-6736(76)92342-4","article-title":"Cimetidine in the treatment of active duodenal and pre-pyloric ulcers","volume":"ii,","author":"BODEMAR, G.; WALAN, A.","year":"1976","unstructured":"BODEMAR, G. & WALAN, A. (1976) Cimetidine in the treatment of active duodenal and pre-pyloric ulcers. Lancet, ii, 161.","journal-title":"Lancet"},{"key":"ref_5","series-title":"Cimetidine: Proceedings of the Second International Symposium on Histamine H2-Receptor Antagonists","first-page":"282","article-title":"A controlled trial of cimetidine in the treatment of gastric ulcer","author":"CICLITIRA, P.J.; J., M.A.C.H.E.L.L.R.; FARTHING, M.J.G.; DICK, A.P.; HUNTER, J.O.","year":"1977","unstructured":"CICLITIRA, P.J., MACHELL. R.J., FARTHING, M.J.G., DICK, A.P. & HUNTER, J.O. (1977) A controlled trial of cimetidine in the treatment of gastric ulcer. In: Cimetidine: Proceedings of the Second International Symposium on Histamine H2-Receptor Antagonists (Ed. by Burland, W.L. & Simkins, M.A.), p. 282. Excerpta Medica, Amsterdam."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0016-5085(78)90773-4","article-title":"Cimetidine and placebo in the treatment of benign gastric ulcer","volume":"74","author":"DYCK, W.P.; BELSITO, A.; FLESHLER, B.; LIEBERMANN, T.R.; DICKINSON, P.B.; WOOD, J.M.","year":"1978","unstructured":"DYCK, W.P., BELSITO, A., FLESHLER, B., LIEBERMANN, T. R., DICKINSON, P.B. & WOOD, J.M. (1978) Cimetidine and placebo in the treatment of benign gastric ulcer, Gastroenterology, 74, 410.","journal-title":"Gastroenterology"},{"key":"ref_7","first-page":"795","article-title":"Cimetidine in patients with gastric ulcer: a multicentre trial","volume":"3","year":"1977","unstructured":"FROST, F., RAHBEK, 1., RUNE. S.J., BIRGER JENSEN, K., GUDMAND-HOYER, E., KRAG, E., RASK-MADSEN, J., WULFF, H.R., GARBOL, J., GOTLIEB JENSEN, K., HOJLUND, M. & NISSEN, V.R. (1977) Cimetidine in patients with gastric ulcer: a multicentre trial. British Medical Journal, 3, 795.","journal-title":"British Medical Journal"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0016-5085(78)90770-9","article-title":"Long term cimetidine in the management of severe duodenal ulcer, dyspepsia","volume":"74","author":"GRAY, G.R.; SMITH, I.S.; MACKENZIE, I.; GILLESPIE, G.","year":"1978","unstructured":"GRAY, G.R., SMITH, I.S., MACKENZIE, I. & GILLESPIE, G. (1978) Long term cimetidine in the management of severe duodenal ulcer, dyspepsia. Gastroenterology, 74, 397.","journal-title":"Gastroenterology"},{"key":"ref_9","article-title":"Treatment of duodenal ulcer with cimetidine","volume":"983","author":"HAGGIE, S.J.; FUMONT, D.C.; WYLLIE, J.H.","year":"1976","unstructured":"HAGGIE, S.J., FUMONT, D.C. & WYLLIE, J.H. (1976) Treatment of duodenal ulcer with cimetidine. Lancet, i, 983.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1136\/bmj.2.6100.1440","article-title":"Preventing recurrence of ulcers","volume":"2","author":"ARTICLE, L.E.A.D.I.N.G.","year":"1977","unstructured":"LEADING ARTICLE (1977) Preventing recurrence of ulcers. British Medical Journal, 2, 1440.","journal-title":"British Medical Journal"},{"key":"ref_11","series-title":"Cimetidine: Proceedings of the Second International Symposium on Histamine H2-Receptor Antagonists","first-page":"287","article-title":"Treatment of gastric ulcer by cimetidine","author":"TRIAL, M.U.L.T.I.C.E.N.T.R.E.","year":"1977","unstructured":"MULTICENTRE TRIAL (1977) Treatment of gastric ulcer by cimetidine. In: Cimetidine: Proceedings of the Second International Symposium on Histamine H2-Receptor Antagonists (Ed. by Burland, W.L. & Simkins, M.A.), p. 287. 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