{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T09:40:25Z","timestamp":1683538825185},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"646","license":[{"start":{"date-parts":[[1979,8,1]],"date-time":"1979-08-01T00:00:00Z","timestamp":302313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1979,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 76-year-old man with pigmentation and Cushing's disease is described, who was found to have a large chromophobe adenoma of the pituitary. Despite normal skull X-rays the presence of bitemporal hemianopia led to the diagnosis which was later confirmed at post-mortem. Adrenalectomy performed in the treatment of Cushing's disease may be followed by skin pigmentation and an enlarging pituitary tumour (Nelson's syndrome), changes which are commonly attributed to the removal of the negative feed-back mechanism. The spontaneous occurrence of these changes in this patient who did not undergo adrenalectomy supports the view that a pituitary tumour pre-exists in cases of Nelson's syndrome and emphasizes the importance of directing initial treatment to the pituitary.<\/jats:p>","DOI":"10.1136\/pgmj.55.646.564","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"564-566","source":"Crossref","is-referenced-by-count":1,"title":["Chromophobe adenoma of the pituitary with Cushing's syndrome and skin pigmentation"],"prefix":"10.1093","volume":"55","author":[{"given":"N","family":"Sterling","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine, Southampton General Hospital, and Faculty of Medicine, University of Southampton , Southampton SO9 4XY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R P","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Southampton General Hospital, and Faculty of Medicine, University of Southampton , Southampton SO9 4XY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1979,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0300-595X(72)80027-6","article-title":"Cushing's syndrome","volume":"1","author":"BESSER, G.M.; EDWARDS, C.R.W.","year":"1972","unstructured":"BESSER, G.M. & EDWARDS, C.R.W. (1972) Cushing's syndrome. Clinics in Endocrinology and Metabolism, 1, 451.","journal-title":"Clinics in Endocrinology and Metabolism"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/bmj.2.5518.847","article-title":"The adrenal cortex in internal medicine","volume":"2","author":"COPE, C.L.","year":"1966","unstructured":"COPE, C.L. (1966) The adrenal cortex in internal medicine. British Medical Journal, 2, 847.","journal-title":"British Medical Journal"},{"key":"ref_3","first-page":"205","article-title":"Subclinical adenoma of the pituitary gland","volume":"12","author":"COSTELLO, R.T.","year":"1936","unstructured":"COSTELLO, R.T. (1936) Subclinical adenoma of the pituitary gland. American Journal of Pathology, 12, 205.","journal-title":"American Journal of Pathology"},{"key":"ref_4","first-page":"137","article-title":"The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism)","volume":"50","author":"CUSHING, H.","year":"1932","unstructured":"CUSHING, H. (1932) The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Bulletin of the Johns Hopkins Hospital, 50, 137.","journal-title":"Bulletin of the Johns Hopkins Hospital"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1136\/bmj.1.6068.1049","article-title":"Pituitary-dependent Cushing's disease","volume":"1","author":"ARTICLE, L.E.A.D.I.N.G.","year":"1977","unstructured":"LEADING ARTICLE (1977) Pituitary-dependent Cushing's disease. British Medical Journal, 1, 1049.","journal-title":"British Medical Journal"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1177\/003591576105400718","article-title":"Ocular symptoms and signs in pituitary tumours","volume":"54","author":"LYLE, T.K.; CLOVER, P.","year":"1961","unstructured":"LYLE, T.K. & CLOVER, P. (1961) Ocular symptoms and signs in pituitary tumours. Proceedings of the Royal Society of Medicine, 54, 611.","journal-title":"Proceedings of the Royal Society of Medicine"},{"key":"ref_7","first-page":"527","article-title":"Cushing's syndrome occurring with pituitary chromophobe tumours. Acta endocrinologica","volume":"32","author":"MARKS, V.","year":"1959","unstructured":"MARKS, V. (1959) Cushing's syndrome occurring with pituitary chromophobe tumours. Acta endocrinologica. Copenhagen, 32, 527.","journal-title":"Copenhagen"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJM195807242590403","article-title":"ACTH-producing tumor of the pituitary gland","volume":"259","author":"NELSON, D.H.; MEAKIN, J.W.; DEALY, J.B.; MATSON, D.D.; EMMERSON, K.; THORN, G.W.","year":"1958","unstructured":"NELSON, D.H., MEAKIN, J.W., DEALY, J.B., MATSON, D.D., EMMERSON, K. & THORN, G.W. (1958) ACTH-producing tumor of the pituitary gland. New England Joutrnal of Medicine, 259, 161.","journal-title":"New England Joutrnal of Medicine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0002-9343(52)90027-2","article-title":"The natural history of Cushing's syndrome","volume":"13","author":"PLOTZ, C.M.; KNOWLTON, A.I.; RAGAN, C.","year":"1952","unstructured":"PLOTZ, C.M., KNOWLTON, A.I. & RAGAN, C. (1952) The natural history of Cushing's syndrome. American Jouirnal of Medicine, 13, 597.","journal-title":"American Jouirnal of Medicine"},{"key":"ref_10","article-title":"Pituitary tumors in patients with Cushing's syndrome","volume":"19","author":"SALASSA, R.M.; KEARNS, T.P.; KERNOHAN, J.W.; SPRAGUE, R.G.; MACCARTY, C.J.","year":"1959","unstructured":"SALASSA, R.M., KEARNS, T.P., KERNOHAN, J.W., SPRAGUE, R.G. & MACCARTY, C.J. 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