{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T07:08:28Z","timestamp":1697785708146},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"646","license":[{"start":{"date-parts":[[1979,8,1]],"date-time":"1979-08-01T00:00:00Z","timestamp":302313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1979,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A patient treated for hypertension with labetalol developed left ventricular failure. When the drug was withdrawn and the BP controlled with 2 other agents, the signs of heart failure regressed. The ill effects in this case could have been because the beta-blocking effects of labetalol are 4 to 6 times greater than the alpha-blocking effects. Caution should be exercised when prescribing this drug for patients with heart failure or with previous symptoms.<\/jats:p>","DOI":"10.1136\/pgmj.55.646.567","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"567-568","source":"Crossref","is-referenced-by-count":8,"title":["Left ventricular failure with labetalol"],"prefix":"10.1093","volume":"55","author":[{"given":"M A","family":"Frais","sequence":"first","affiliation":[{"name":"Broadgreen Hospital , Thomas Lane, Liverpool L14 3LB"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T J","family":"Bayley","sequence":"additional","affiliation":[{"name":"Broadgreen Hospital , Thomas Lane, Liverpool L14 3LB"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1979,8,1]]},"reference":[{"key":"ref_1","article-title":"A review of the animal pharmacology of labetalol, a combined alphaand betaadrenoceptor-blocking drug","volume":"681","author":"BRITTAIN, R.T.; LEVY, G.P.","year":"1976","unstructured":"BRITTAIN, R.T. & LEVY, G.P. (1976) A review of the animal pharmacology of labetalol, a combined alphaand betaadrenoceptor-blocking drug. British Journal of Clinical Pharmacology (Suppl.), 681.","journal-title":"British Journal of Clinical Pharmacology (Suppl.)"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1136\/bmj.2.6089.737","article-title":"Pressor response after intravenous labetalol","volume":"2","author":"CROFTON, M.; GABRIEL, R.","year":"1977","unstructured":"CROFTON, M. & GABRIEL, R. (1977) Pressor response after intravenous labetalol. British Medical Journal, 2, 737.","journal-title":"British Medical Journal"},{"key":"ref_3","first-page":"733","article-title":"The haemodynamic effects of long-term oral labetalol","volume":"3","author":"EDWARDS, R.C.; RAFTERY, E.B.","year":"1976","unstructured":"EDWARDS, R.C. & RAFTERY, E.B. (1976) The haemodynamic effects of long-term oral labetalol. British Journal of Clinical Pharmacology, 3, 733.","journal-title":"British Journal of Clinical Pharmacology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-2125.1974.tb01702.x","article-title":"The effects of oral AH5158, a combined alpha and beta adrenoceptor antagonist, in healthy volunteers","volume":"1","author":"RICHARDS, D.A.; WOODINGS, E.P.; STEPHENS, M.D.B.; MACONOCHIE, J.G.","year":"1974","unstructured":"RICHARDS, D.A., WOODINGS, E.P., STEPHENS, M.D.B. & MACONOCHIE, J.G. (1974) The effects of oral AH5158, a combined alpha and beta adrenoceptor antagonist, in healthy volunteers. British Journal of Clinical Pharmacology, 1, 505.","journal-title":"British Journal of Clinical Pharmacology"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/55\/646\/567\/50159308\/postgradmedj-55-567.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/55\/646\/567\/50159308\/postgradmedj-55-567.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T09:24:42Z","timestamp":1683537882000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/55\/646\/567\/7063536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,8,1]]},"references-count":4,"journal-issue":{"issue":"646","published-online":{"date-parts":[[1979,8,1]]},"published-print":{"date-parts":[[1979,8,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.55.646.567","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1979,8]]},"published":{"date-parts":[[1979,8,1]]}}}