{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T15:44:14Z","timestamp":1698075854720},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"647","license":[{"start":{"date-parts":[[1979,9,1]],"date-time":"1979-09-01T00:00:00Z","timestamp":304992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1979,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Oculomycosis may be divided into the orbital infections of phycomycosis of Aspergillus and other species and the infections of the globe. The latter comprise endogenous, post-surgical or traumatic intra-ocular infections and direct infections of the cornea: these are the commonest form of oculomycosis. They are not easy to differentiate from other, more common causes of septic infection of the eye. The early recognition of fungal infections of the eye thus rests on maintaining an efficient service for all septic infections of the eye.<\/jats:p>\n               <jats:p>Candida albicans and other dimorphic fungal infections are best treated with flucytosine combined with either polyenes such as amphotericin B and natamycin or combined with imidazoles such as clotrimazole or miconazole.<\/jats:p>\n               <jats:p>Aspergillus spp. account for about 50% of the cases of filamentous fungal infection of the cornea but more than 100 species of varying pathogenicity and drug sensitivity have been implicated. Econazole, clotrimazole or miconazole combined with thiabendazole are recommended for Aspergillus spp. Econazole, thiabendazole or miconazole combined with flucytosine for Cladosporium sp. For Fusarium solani and other species econazole is the best drug but some isolates are sensitive to thiabendazole or other imidazoles.<\/jats:p>\n               <jats:p>Alternatively, filamentous fungal infections may be treated with natamycin which has a broad spectrum of activity; but does not penetrate well and, like other polyenes, should not be combined with imidazole antifungal chemotherapy because of antagonistic drug interaction.<\/jats:p>\n               <jats:p>Overall, econazole emerges as the most widely acting drug; but successful results are dependent on rather complex investigation with intensive and protracted care that can best be provided in a few centres of referral.<\/jats:p>","DOI":"10.1136\/pgmj.55.647.625","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"625-628","source":"Crossref","is-referenced-by-count":10,"title":["Recognition and chemotherapy of oculomycosis"],"prefix":"10.1093","volume":"55","author":[{"given":"Barrie R","family":"Jones","sequence":"first","affiliation":[{"name":"British Postgraduate Medical Federation, University of London , London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne M","family":"Clayton","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, St John's Hospital for Diseases of the Skin , London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erasmus O","family":"Oji","sequence":"additional","affiliation":[{"name":"British Postgraduate Medical Federation, University of London , London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1979,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/ajcp\/35.3.195","article-title":"Pathogenic Acanthamoeba (Hartmonella)","volume":"5","author":"CULBERTSON, C.G.","year":"1961","unstructured":"CULBERTSON, C.G. (1961) Pathogenic Acanthamoeba (Hartmonella). American Journal of Clinical Pathology, 5, 195.","journal-title":"American Journal of Clinical Pathology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/ajcp\/43.4_ts.383","article-title":"Isolation of additional strains of pathogenic Hartmonella sp","volume":"43","author":"CULBERTSON, C.G.; ENSMINGER, P.W.; OVERTON, W.M.","year":"1965","unstructured":"CULBERTSON, C.G., ENSMINGER, P.W. & OVERTON, W.M. (1965) Isolation of additional strains of pathogenic Hartmonella sp. (Acanthamoeba). American Journal of Clinical Pathology, 43, 383.","journal-title":"(Acanthamoeba). American Journal of Clinical Pathology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/0002-9394(75)90730-8","article-title":"Principles in the management of oculomycosis. XXXI Edward Jackson Memorial Lecture","volume":"79","author":"JONES, B.R.","year":"1975","unstructured":"JONES, B.R. (1975) Principles in the management of oculomycosis. XXXI Edward Jackson Memorial Lecture. American Journal of Ophthalmology, 79, 719.","journal-title":"American Journal of Ophthalmology"},{"key":"ref_4","series-title":"Proceedings of the XXIII International Congress of Ophthalmology, Kyoto; Excerpta Medica","article-title":"Fungal infection of the cornea","author":"JONES, B.R.; CLAYTON, Y.M.","year":"1978","unstructured":"JONES, B.R. & CLAYTON, Y.M. (1978) Fungal infection of the cornea. In: Proceedings of the XXIII International Congress of Ophthalmology, Kyoto, May, 1978. Excerpta Medica, Amsterdam."},{"key":"ref_5","first-page":"758","article-title":"Corneal and intra-ocular infection due to Fusarium solani","volume":"89","author":"JONES, B.R.; JONES, D.B.; LIM, A.S.M.; BRON, A.J.; MORGAN, G.; CLAYTON, Y.M.","year":"1969","unstructured":"JONES, B.R., JONES, D.B., LIM, A.S.M., BRON, A.J., MORGAN, G. & CLAYTON, Y.M. (1969) Corneal and intra-ocular infection due to Fusarium solani. Transactions of the Ophthalmological Society of the United Kingdom, 89, 758.","journal-title":"Transactions of the Ophthalmological Society of the United Kingdom"},{"key":"ref_6","first-page":"727","article-title":"Direct fungal infection of the eye in Britain","volume":"89","author":"JONES, B.R.; RICHARDS, A.B.; MORGAN, G.","year":"1969","unstructured":"JONES, B.R., RICHARDS, A.B. & MORGAN, G. (1969) Direct fungal infection of the eye in Britain. Transactions of the Ophthalmological Society of the United Kingdom, 89, 727.","journal-title":"Transactions of the Ophthalmological Society of the United Kingdom"},{"key":"ref_7","first-page":"781","article-title":"Mycotic keratitis in South Florida: a review of thirty-nine cases","volume":"89","author":"JONES, D.B.; SEXTON, R.; REBELL, G.","year":"1969","unstructured":"JONES, D.B., SEXTON, R. & REBELL, G. (1969) Mycotic keratitis in South Florida: a review of thirty-nine cases. Transactions of the Ophthalmological Society of the United Kingdom, 89, 781.","journal-title":"Transactions of the Ophthalmological Society of the United Kingdom"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/0002-9394(66)92200-8","article-title":"Ocular absorption of thiabendazole-14C by the rabbit","volume":"62","author":"ROBINSON, H.J.; GRAESSLE, O.E.; LEHMAN, E.G.; KELLEY, K.L.; GEOFFROY, R.F.; ROSENBLUM, C.","year":"1966","unstructured":"ROBINSON, H.J., GRAESSLE, O.E., LEHMAN, E.G., KELLEY, K.L., GEOFFROY, R.F. & ROSENBLUM, C. (1966) Ocular absorption of thiabendazole-14C by the rabbit. American Journal of Ophthalmology, 62, 710.","journal-title":"American Journal of Ophthalmology"},{"key":"ref_9","first-page":"thesis.","article-title":"Laboratory studies of some fungi incriminated as opportunistic pathogens","author":"WINGFIELD, H.","year":"1974","unstructured":"WINGFIELD, H. (1974) Laboratory studies of some fungi incriminated as opportunistic pathogens. F.I.M.L.S. thesis."}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/55\/647\/625\/50159440\/postgradmedj-55-625.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/55\/647\/625\/50159440\/postgradmedj-55-625.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T09:33:54Z","timestamp":1683538434000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/55\/647\/625\/7063944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,9,1]]},"references-count":9,"journal-issue":{"issue":"647","published-online":{"date-parts":[[1979,9,1]]},"published-print":{"date-parts":[[1979,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.55.647.625","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1979,9]]},"published":{"date-parts":[[1979,9,1]]}}}