{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:56:17Z","timestamp":1762541777175},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"649","license":[{"start":{"date-parts":[[1979,11,1]],"date-time":"1979-11-01T00:00:00Z","timestamp":310262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1979,11,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A patient is described who developed symptomatic hypopituitarism within 18 months of radiotherapy for nasopharyngeal carcinoma. Detailed investigation indicated a lesion at hypothalamic level. The effect of radiation on hypothalamic-pituitary function is discussed.<\/jats:p>","DOI":"10.1136\/pgmj.55.649.812","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"812-813","source":"Crossref","is-referenced-by-count":3,"title":["Symptomatic hypothalamic hypopituitarism following radiotherapy"],"prefix":"10.1093","volume":"55","author":[{"given":"B M","family":"Frier","sequence":"first","affiliation":[{"name":"Department of Medicine, Western General Hospital , Edinburgh EH4 2XU"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J M","family":"Corrall","sequence":"additional","affiliation":[{"name":"Department of Medicine, Western General Hospital , Edinburgh EH4 2XU"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1979,11,1]]},"reference":[{"key":"ref_1","article-title":"The thyrotrophin-releasing hormone test in diseases of the pituitary and hypothalamus","volume":"759","author":"HALL, R.; ORMSTON, B.J.; BESSER, G.M.; CRYER, R.J.; MCKENDRICK, M.","year":"1972","unstructured":"HALL, R., ORMSTON, B.J., BESSER, G.M., CRYER, R.J. & MCKENDRICK, M. (1972) The thyrotrophin-releasing hormone test in diseases of the pituitary and hypothalamus. Lancet, i, 759.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1136\/bmj.1.5846.152","article-title":"Hypopituitarism after extracranial irradiation: Evidence for hypothalamic origin","volume":"1","author":"LARKINS, R.G.; MARTIN, F.I.R.","year":"1973","unstructured":"LARKINS, R.G. & MARTIN, F.I.R. (1973) Hypopituitarism after extracranial irradiation: Evidence for hypothalamic origin. British Medical Journal, 1, 152.","journal-title":"British Medical Journal"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1001\/jama.1976.03270150025024","article-title":"Primary and secondary hypothyroidism in nasopharyngeal carcinoma","volume":"236","author":"ROSENTHAL, M.B.; GOLDFINE, I.D.","year":"1976","unstructured":"ROSENTHAL, M.B. & GOLDFINE, I.D. (1976) Primary and secondary hypothyroidism in nasopharyngeal carcinoma. 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Annals of Internal Medicine, 83, 771.","journal-title":"Annals of Internal Medicine"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0009-9260(66)80043-0","article-title":"Hypopituitary dwarfism following radiotherapy for nasopharyngeal carcinoma","volume":"17","author":"TAN, B.C.; KUNARATNAM, N.","year":"1966","unstructured":"TAN, B.C. & KUNARATNAM, N. (1966) Hypopituitary dwarfism following radiotherapy for nasopharyngeal carcinoma. Clinical Radiology, 17, 302.","journal-title":"Clinical Radiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/path.1700730216","article-title":"Epidermoid carcinoma of the nasopharynx among Chinese: a study of 31 necropsies","volume":"63","author":"TEOH, T.B.","year":"1957","unstructured":"TEOH, T.B. (1957) Epidermoid carcinoma of the nasopharynx among Chinese: a study of 31 necropsies. Journal of Pathology and Bacteriology, 63, 451.","journal-title":"Journal of Pathology and Bacteriology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1056\/NEJM197711242972103","article-title":"Hypothalamic dysfunction in secondary amenorrhea associated with simple weight loss","volume":"297","author":"VIGERSKY, R.A.; ANDERSEN, A.E.; THOMPSON, R.H.; LORlAUX, D.L.","year":"1977","unstructured":"VIGERSKY, R.A., ANDERSEN, A.E., THOMPSON, R.H. & LORlAUX, D.L. (1977) Hypothalamic dysfunction in secondary amenorrhea associated with simple weight loss. New England Journal of Medicine, 297, 1141.","journal-title":"New England Journal of Medicine"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/55\/649\/812\/50093580\/postgradmedj-55-812.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/55\/649\/812\/50093580\/postgradmedj-55-812.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T10:05:33Z","timestamp":1683540333000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/55\/649\/812\/7063889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,11,1]]},"references-count":7,"journal-issue":{"issue":"649","published-online":{"date-parts":[[1979,11,1]]},"published-print":{"date-parts":[[1979,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.55.649.812","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1979,11]]},"published":{"date-parts":[[1979,11,1]]}}}