{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:16:01Z","timestamp":1759342561718},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"653","license":[{"start":{"date-parts":[[1980,3,1]],"date-time":"1980-03-01T00:00:00Z","timestamp":320716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,3,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A 27-year-old man with severe infantile kyphoscoliosis suffered from recurrent respiratory tract infections during childhood and early adult life. He deteriorated and was found to have pernicious anaemia and common variable immunodeficiency with hypogammaglobulinaemia and impairment of cell-mediated immunity. Marked clinical improvement has followed the institution of effective gamma-globulin replacement.<\/jats:p>","DOI":"10.1136\/pgmj.56.653.209","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"209-212","source":"Crossref","is-referenced-by-count":1,"title":["Pernicious anaemia and hypogammaglobulinaemia in a patient with severe infantile kyphoscoliosis"],"prefix":"10.1093","volume":"56","author":[{"given":"F I","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine (Gastroenterology), Victoria Hospital , Blackpool"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D R","family":"Norfolk","sequence":"additional","affiliation":[{"name":"Department of Medicine (Gastroenterology), Victoria Hospital , Blackpool"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1980,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1136\/bmj.2.5407.486","article-title":"Congenital hypogammaglobulinaemia with steatorrhoea in two adult brothers","volume":"2","author":"ALLEN, G.E.; HADDEN, D.R.","year":"1964","unstructured":"ALLEN, G.E. & HADDEN, D.R. (1964) Congenital hypogammaglobulinaemia with steatorrhoea in two adult brothers. British Medical Journal, 2, 486.","journal-title":"British Medical Journal"},{"key":"ref_2","first-page":"305","article-title":"Immunodeficiency with short-limbed dwarfs","volume":"24","author":"AMMANN, A.J.","year":"1977","unstructured":"AMMANN, A.J. (1977) Immunodeficiency with short-limbed dwarfs. Pediatric Clinics of North America, 24, 305.","journal-title":"Pediatric Clinics of North America"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00005792-195909000-00004","article-title":"Cardiorespiratory failure in kyphoscoliosis","volume":"38","author":"BERGOFSKY, E.H.; TURINO, G.M.; FISHMAN, A.P.","year":"1959","unstructured":"BERGOFSKY, E.H., TURINO, G.M. & FISHMAN, A.P. (1959) Cardiorespiratory failure in kyphoscoliosis. Medicine. Baltimore, 38, 263.","journal-title":"Medicine. Baltimore"},{"key":"ref_4","article-title":"Acquired agammaglobulinaemia in siblings","volume":"234","author":"ROSENBERG, H.A.","year":"1965","unstructured":"ROSENBERG, H.A. (1965) Acquired agammaglobulinaemia in siblings. Lancet, i, 234.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0002-9343(70)90097-5","article-title":"Clinical, serologic and leucocyte function studies on patients with idiopathic \"acquired\" agammaglobulinemia and their families","volume":"48","author":"DOUGLAS, D.D.; GOLDBERG, L.S.; FUDENBERG, H.H.","year":"1970","unstructured":"DOUGLAS, D.D., GOLDBERG, L.S. & FUDENBERG, H.H. (1970) Clinical, serologic and leucocyte function studies on patients with idiopathic \"acquired\" agammaglobulinemia and their families. 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(Ed. by Lipkin, M. & Good, R.A.), p. 93. Plenum Medical, New York and London. WEBSTER, A.B.D., ASHERSON, G.L., BALLARD, J., SHINER, M., SLAVIN, G., LEVI, J. & KENWRIGHT, S. (1973) Immune deficiency disease and lymphoid nodular hyperplasia. Gut, 14, 829.","journal-title":"Gut; Immune deficiency disease and lymphoid nodular hyperplasia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1136\/bmj.1.6021.1314","article-title":"Polyarthritis in adults with hypogammaglobulinaemia and its rapid response to immunoglobulin therapy","volume":"1","author":"WEBSTER, A.B.D.; LoEwI, G.; DOURMASHKIN, R.D.; GOULDING, D.N.; WARD, D.J.; ASHERSON, G.L.","year":"1976","unstructured":"WEBSTER, A.B.D., LoEwI, G., DOURMASHKIN, R.D., GOULDING, D.N., WARD, D.J. & ASHERSON, G.L. (1976) Polyarthritis in adults with hypogammaglobulinaemia and its rapid response to immunoglobulin therapy. 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