{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:13:57Z","timestamp":1760645637090},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"655","license":[{"start":{"date-parts":[[1980,5,1]],"date-time":"1980-05-01T00:00:00Z","timestamp":325987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A patient who developed significant metabolic acidosis and severe hyperkalaemia while taking Moduretic (amiloride and hydrochlorothiazide) is reported. During the period of hyperkalaemia (maximum potassium 7-6 mmol\/l) the patient\u2019s whole body potassium content was normal. His acid-base balance and serum potassium returned to normal some 10 days after stopping the drug. The possible mechanism of acidosis and hyperkalaemia in this patient is discussed.<\/jats:p>","DOI":"10.1136\/pgmj.56.655.348","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"348-350","source":"Crossref","is-referenced-by-count":13,"title":["Moduretic-induced metabolic acidosis and hyperkalaemia"],"prefix":"10.1093","volume":"56","author":[{"given":"H H","family":"Wan","sequence":"first","affiliation":[{"name":"University Hospital of South Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M D W","family":"Lye","sequence":"additional","affiliation":[{"name":"University Hospital of South Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1980,5,1]]},"reference":[{"key":"ref_1","first-page":"1618","article-title":"Diuretics in the elderly","volume":"1","author":"BAILEY, R.R.","year":"1978","unstructured":"BAILEY, R.R. (1978) Diuretics in the elderly. British Medical Journal, 1, 1618.","journal-title":"British Medical Journal"},{"key":"ref_2","first-page":"472","article-title":"Renal Disease","volume":"90","author":"BLACK, D.A.K.","year":"1972","unstructured":"BLACK, D.A.K. (1972) Renal Disease, p. 472. Blackwell Scientific Publications, Oxford. GABOW, P.A., MOORE, S. & SCHRIER, R.W. (1979) Spironolactone-induced hyperchloremic acidosis in cirrhosis. Annals of Internal Medicine, 90, 338.","journal-title":"Annals of Internal Medicine; Spironolactone-induced hyperchloremic acidosis in cirrhosis"},{"key":"ref_3","first-page":"839","article-title":"The Pharmacological Basis of Therapeutics","author":"GOODMAN, L.S.; GILMAN, A.","year":"1975","unstructured":"GOODMAN, L.S. & GILMAN, A. (1975) The Pharmacological Basis of Therapeutics. 5th edn, p. 839. MacMillan Publishing Co. Inc., New York.","edition":"5th edn"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1001\/jama.1973.03220280028007","article-title":"Adverse reactions to spironolactone","volume":"225","author":"GREENBLATT, D.J.; KOCH-WESER, J.","year":"1973","unstructured":"GREENBLATT, D.J. & KOCH-WESER, J. (1973) Adverse reactions to spironolactone. Journal of the American Medical Association, 225, 40.","journal-title":"Journal of the American Medical Association"},{"key":"ref_5","first-page":"147","article-title":"Spironolactone-associated aggravation of renal function impairment","volume":"83","author":"NEALE, T.J.; LYNN, K.L.; BAILEY, R.R.","year":"1976","unstructured":"NEALE, T.J., LYNN, K.L. & BAILEY, R.R. (1976) Spironolactone-associated aggravation of renal function impairment. New Zealand Medical Journal, 83, 147.","journal-title":"New Zealand Medical Journal"},{"key":"ref_6","first-page":"1118","article-title":"Possible role for impaired renal prostaglandin production in pathogenesis of hyporeninaemic hypoaldosteronism","volume":"ii,","author":"FLAMENBAUM, W.","year":"1978","unstructured":"FLAMENBAUM, W. (1978) Possible role for impaired renal prostaglandin production in pathogenesis of hyporeninaemic hypoaldosteronism. Lancet, ii, 1118.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ki.1977.63","article-title":"Relationship of renal ammonia production and potassium homeostasis","volume":"11","author":"TANNEN, R.L.","year":"1977","unstructured":"TANNEN, R.L. (1977) Relationship of renal ammonia production and potassium homeostasis. Kidney International, 11, 453.","journal-title":"Kidney International"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/56\/655\/348\/50215313\/postgradmedj-56-348.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/56\/655\/348\/50215313\/postgradmedj-56-348.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T20:12:25Z","timestamp":1683749545000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/56\/655\/348\/7050622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,5,1]]},"references-count":7,"journal-issue":{"issue":"655","published-online":{"date-parts":[[1980,5,1]]},"published-print":{"date-parts":[[1980,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.56.655.348","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1980,5]]},"published":{"date-parts":[[1980,5,1]]}}}