{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:47:56Z","timestamp":1759481276185},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"655","license":[{"start":{"date-parts":[[1980,5,1]],"date-time":"1980-05-01T00:00:00Z","timestamp":325987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,5,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Charcoal haemoperfusion was successful in the treatment of severe butobarbitone poisoning complicated by resistant hypotension. At the same time the rapid removal of paracetamol may have lessened the severity of the subsequent hepatic injury. The mechanism and management of shock associated with barbiturate poisoning, and the possible application of haemoperfusion in paracetamol poisoning are discussed.<\/jats:p>","DOI":"10.1136\/pgmj.56.655.363","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"363-365","source":"Crossref","is-referenced-by-count":5,"title":["Severe barbiturate and paracetamol overdose: the simultaneous removal of both poisons by haemoperfusion"],"prefix":"10.1093","volume":"56","author":[{"given":"M","family":"Helliwell","sequence":"first","affiliation":[{"name":"Poisons Unit, Guy\u2019s Hospital , London SE1 9RT"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1980,5,1]]},"reference":[{"key":"ref_1","article-title":"Oral methionine in the treatment of severe paracetamol (acetaminophen) overdose","volume":"829","author":"GOULDING, R.","year":"1976","unstructured":"GOULDING, R. (1976a) Oral methionine in the treatment of severe paracetamol (acetaminophen) overdose. Lancet, ii, 829.","journal-title":"Lancet"},{"issue":"4","key":"ref_2","first-page":"105","article-title":"The use of methionine for acute paracetamol poisoning","volume":"4","author":"CROME, P.; VOLANS, G.N.; VALE, J.A.; WIDDOP, B.; GOULDING, R.; WILLIAMS, R.","year":"1976","unstructured":"CROME, P., VOLANS, G.N., VALE, J.A., WIDDOP, B., GOULDING, R. & WILLIAMS, R. (1976b) The use of methionine for acute paracetamol poisoning. Journal of International Medical Research, 4 (suppl. 4), 105.","journal-title":"Journal of International Medical Research"},{"key":"ref_3","article-title":"Controlled trial of cysteamine in treatment of acute paracetamol (acetaminophen) poisoning","volume":"111","year":"1976","unstructured":"DOUGLAS, A.P., HAMLYN, A.N. & JAMES, 0. (1976) Controlled trial of cysteamine in treatment of acute paracetamol (acetaminophen) poisoning. 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(1977) Recent advances in the pharmacology of catecholamines. Intensive Care Medicine, 3, 233.","journal-title":"Intensive Care Medicine"},{"key":"ref_8","series-title":"Proceedings of the European Society for Artificial Organs","first-page":"202","article-title":"Experience with haemoperfusion in the treatment of acute drug intoxication","volume":"5","author":"HAMPEL, G.; WIDDOP, B.","year":"1978","unstructured":"HAMPEL, G. & WIDDOP, B. (1978) Experience with haemoperfusion in the treatment of acute drug intoxication. Proceedings of the European Society for Artificial Organs, 5, 202."},{"key":"ref_9","article-title":"Plasma paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage","volume":"519","author":"PRESCOTT, L.F.; WRIGHT, N.; ROSCOE, P.; BROWN, S.S.","year":"1971","unstructured":"PRESCOTT, L.F., WRIGHT, N., ROSCOE, P. & BROWN, S.S. (1971) Plasma paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. 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