{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T15:35:11Z","timestamp":1726068911812},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"659","license":[{"start":{"date-parts":[[1980,9,1]],"date-time":"1980-09-01T00:00:00Z","timestamp":336614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In normal subjects, receiving multiple dosing regimens with Slophyllin and Phyllocontin in does calculated to give either 4 mg\/kg or 6mg\/kg theophylline free acid twice daily, serum theophylline concentrations were frequently less than 8 mg\/l. Accumulation of the serum theophylline trough concentration occurred during the first 3 days of multiple dosing, and was followed by subsequent stabilization or even decline in serum theophylline trough concentrations. Side effects were noted with both Slophyllin and Phyllocontin, but only on the higher dosage regimens; they occurred within 24--48 hr of starting the drug, and tended to diminish if dosing was continued. The accumulation effect of serum theophylline concentrations may explain the timing of adverse effects, and should be avoided by starting methylxanthine therapy at a low dose. This may be increased after a few days. Further dosage adjustment may be necessary in some patients and should be facilitated by measurement of serum theophylline trough concentrations.<\/jats:p>","DOI":"10.1136\/pgmj.56.659.638","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"638-641","source":"Crossref","is-referenced-by-count":3,"title":["Serum theophylline concentrations during multiple dosing with two sustained release methylxanthine preparations in normal subjects"],"prefix":"10.1093","volume":"56","author":[{"given":"J G","family":"Prior","sequence":"first","affiliation":[{"name":"Department of Thoracic Medicine, New Cross Hospital , London SE14 SER"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Berry","sequence":"additional","affiliation":[{"name":"Poisons Unit, New Cross Hospital , London SE14 SER"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Cochrane","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine, New Cross Hospital , London SE14 SER"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1980,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00561560","article-title":"Plasma theophylline level and ventilatory function in chronic obstructive pulmonary disease during prolonged oral treatment with choline theophyllinate","volume":"8","author":"BUELOW, K.R.; LARSSON, H.; LEIDEMAN, T.","year":"1975","unstructured":"BUELOW, K.R., LARSSON, H. & LEIDEMAN, T. (1975) Plasma theophylline level and ventilatory function in chronic obstructive pulmonary disease during prolonged oral treatment with choline theophyllinate. European Journal of Clinical Pharmacology, 8, 119.","journal-title":"European Journal of Clinical Pharmacology"},{"key":"ref_2","article-title":"The influence of certain environmental factors on theophylline half-life in man","author":"CALDWELL, J.; LAWRIE, C.A.","year":"1979","unstructured":"CALDWELL, J. & LAWRIE, C.A. (1979) The influence of certain environmental factors on theophylline half-life in man. Presented at British Pharmacological Society 18-19 Dec. 1979."},{"key":"ref_3","first-page":"700","article-title":"Double-blind cross-over study of slow release oral salbutamol and aminophylline at night for prevention of nocturnal asthma","volume":"34","author":"FAIRFAX, A.J.; McNABB, W.R.; DAVIES, H.J.; SPIRO, S.G.","year":"1979","unstructured":"FAIRFAX, A.J., McNABB, W.R., DAVIES, H.J. & SPIRO, S.G. (1979) Double-blind cross-over study of slow release oral salbutamol and aminophylline at night for prevention of nocturnal asthma. Thorax, 34, 700.","journal-title":"Thorax"},{"key":"ref_4","article-title":"Clinical experience with theophylline","volume":"235","author":"JACOBS, M.H.; SENIOR, R.M.; KESSLER, G.","year":"1976","unstructured":"JACOBS, M.H., SENIOR, R.M. & KESSLER, G. (1976) Clinical experience with theophylline. Journal of the American Medical Association, 235, 1983.","journal-title":"Journal of the American Medical Association"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/cpt1972133349","article-title":"Pharmacokinetics of theophylline. Application to adjustment of the clinical dose of aminophylline","volume":"13","author":"JENNE, J.W.; WYZE, E.; ROOD, F.S.; MAcDONALD, F.M.","year":"1972","unstructured":"JENNE, J.W., WYZE, E., ROOD, F.S. & MAcDONALD, F.M. (1972) Pharmacokinetics of theophylline. 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