{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T14:48:30Z","timestamp":1770734910996,"version":"3.49.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"662","license":[{"start":{"date-parts":[[1980,12,1]],"date-time":"1980-12-01T00:00:00Z","timestamp":344476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1980,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was designed to evaluate the zinc metabolism in adults of both sexes with thyroid disease. Plasma and erythrocyte zinc concentration and urinary zinc excretion were investigated. The mean concentration of plasma zinc in hypothyroid patients and in euthyroid patients, previously either hyperthyroid or hypothyroid, was lower than that of control subjects, whereas no statistically significant differences were observed in plasma zinc values between hyperthyroid patients and control subjects. The average erythrocyte zinc level in patients with thyroid disease was significantly lower than that in control subjects. Erythrocyte zinc concentration was significantly decreased in hyperthyroidism compared with hypothyroidism, or patients previously either hyperthyroid or hypothyroid but now euthyroid. Increased urinary zinc excretion in hyperthyroidism was noticed compared to euthyroid and hypothyroid patients and to control subjects. Increased urinary zinc concentrations may result from increased tissue catabolism such as muscle. The results of this study suggest that abnormal zinc metabolism occurs commonly in patients with thyroid disease.<\/jats:p>","DOI":"10.1136\/pgmj.56.662.833","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:39:26Z","timestamp":1230583166000},"page":"833-837","source":"Crossref","is-referenced-by-count":26,"title":["Zinc metabolism in thyroid disease"],"prefix":"10.1093","volume":"56","author":[{"given":"Y","family":"Nishi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Hiroshima University School of Medicine , 1\u20132\u20133 Kasumi, Hiroshima , Japan 734"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Kawate","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hiroshima University School of Medicine , 1\u20132\u20133 Kasumi, Hiroshima , Japan 734"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hiroshima University School of Medicine , 1\u20132\u20133 Kasumi, Hiroshima , Japan 734"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1980,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1542\/peds.62.3.408","article-title":"Zinc","volume":"62","author":"BARNESS, L.A.","year":"1978","unstructured":"BARNESS, L. A. (1978) Zinc. Pediatrics, 62, 408.","journal-title":"Pediatrics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1136\/pgmj.53.617.143","article-title":"Zinc metabolism and thyroid status","volume":"53","author":"BREMNER, W.F.; FELL, G.S.","year":"1977","unstructured":"BREMNER, W. F. & FELL, G. S. (1977) Zinc metabolism and thyroid status. Postgraduate Medical Journal, 53, 143.","journal-title":"Postgraduate Medical Journal"},{"key":"ref_3","article-title":"Urinary zinc levels as an indication of muscle catabolism","volume":"280","author":"FELL, G.S.; FLECK, A.; CUTHBERTSON, D.P.; QUEEN, K.; MORRISON, C.; BESSENT, R.G.; HUSAIN, S.L.","year":"1973","unstructured":"FELL, G. S., FLECK, A., CUTHBERTSON, D. P., QUEEN, K., MORRISON, C., BESSENT, R. G. & HUSAIN, S. L. (1973) Urinary zinc levels as an indication of muscle catabolism. Lancet, i, 280.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0304-4165(72)90191-2","article-title":"Competition for zinc among serum albumin and amino acids","volume":"273","author":"GIROUX, E.L.; HENKIN, R.I.","year":"1972","unstructured":"GIROUX, E. L. & HENKIN, R. I. (1972) Competition for zinc among serum albumin and amino acids. Biochinica et biophysica acta, 273, 64.","journal-title":"Biochinica et biophysica acta"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0065-3101(22)00736-8","article-title":"Trace elements in pediatric nutrition","volume":"24","author":"HAMBIDGE, K.M.","year":"1977","unstructured":"HAMBIDGE, K. M. (1977) Trace elements in pediatric nutrition. Advances in Pediatrics, 24, 191.","journal-title":"Advances in Pediatrics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0025-7125(16)31861-2","article-title":"Trace metals in endocrinology","volume":"60","author":"HENKIN, R.I.","year":"1976","unstructured":"HENKIN, R. I. (1976) Trace metals in endocrinology. Medical Clinics of North America, 60, 779.","journal-title":"Medical Clinics of North America"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00000441-197609000-00006","article-title":"Altered copper and zinc metabolism in primary hyperparathyroidism","volume":"272","author":"MALETTE, L.E.; HENKIN, R.I.","year":"1976","unstructured":"MALETTE, L. E. & HENKIN, R. I. (1976) Altered copper and zinc metabolism in primary hyperparathyroidism. American Journal of the Medical Sciences, 272, 167.","journal-title":"American Journal of the Medical Sciences"},{"issue":"645","key":"ref_8","article-title":"Red cell zinc and red cell zinc metalloenzymes in hyperthyroidism","volume":"76","author":"PANGARO, J.A.; WEINSTEIN, M.; DEVETAK, M.C.; SOTO, R.J.","year":"1974","unstructured":"PANGARO, J. A., WEINSTEIN, M., DEVETAK, M. C. & SOTO, R. J. (1974) Red cell zinc and red cell zinc metalloenzymes in hyperthyroidism. Acta endocrinologica, 76 645.","journal-title":"Acta endocrinologica"},{"key":"ref_9","first-page":"211","article-title":"Zinc deficiency in man; studies in sickle-cell disease. Trace Elements in Human","author":"PRASAD, A.S.; ABBASI, A.; ORTEGA, J.","year":"1977","unstructured":"PRASAD, A. S., ABBASI, A. & ORTEGA, J. (1977) Zinc deficiency in man; studies in sickle-cell disease. Trace Elements in Human and Animal Nutrition. (Ed by Underwood, E. J.), Academic Press, New York, p. 211."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1210\/jcem-34-6-911","article-title":"The nature of the metabolic bone disorder in acromegaly","volume":"34","author":"RIGGS, B.L.; RANDALL, R.V.; WAHNER, H.W.; JOWSEY, J.; KELLY, P.J.; SINGH, M.","year":"1972","unstructured":"RIGGS, B. L., RANDALL, R. V., WAHNER, H. W., JOWSEY, J., KELLY, P. J. & SINGH, M. (1972) The nature of the metabolic bone disorder in acromegaly. Journal of Clinical Endocrinology and Metabolism, 34, 911.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_11","first-page":"137","article-title":"[The relationship of carbonic anhydrase and zinc in erythrocytes.]","volume":"98","author":"SEINO, M.; ISHIKAWA, N.; SHIRAISHI, T.; TAKAKUWA, S.","year":"1976","unstructured":"SEINO, M., ISHIKAWA, N., SHIRAISHI, T. & TAKAKUWA, S. (1976) [The relationship of carbonic anhydrase and zinc in erythrocytes.] Igakunoayumi, 98, 137 [Japanese].","journal-title":"Igakunoayumi"},{"key":"ref_12","article-title":"Trace Elements in Human and Animal Nutrition","author":"UNDERWOOD, E.J.","year":"1977","unstructured":"UNDERWOOD, E. J. (Ed.) (1977) Trace Elements in Human and Animal Nutrition. Academic Press, New York."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/BF01468120","article-title":"Untersuchungen zur Pathophysiologie des Zinkstoffwechsels","volume":"34","author":"WOLFF, H.P.","year":"1956","unstructured":"WOLFF, H. P. (1956) Untersuchungen zur Pathophysiologie des Zinkstoffwechsels. Klinische Wochenschrift, 34, 409.","journal-title":"Klinische Wochenschrift"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/56\/662\/833\/50215642\/postgradmedj-56-833.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/56\/662\/833\/50215642\/postgradmedj-56-833.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T06:26:59Z","timestamp":1684823219000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/56\/662\/833\/7063906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,12,1]]},"references-count":13,"journal-issue":{"issue":"662","published-online":{"date-parts":[[1980,12,1]]},"published-print":{"date-parts":[[1980,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.56.662.833","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1980,12]]},"published":{"date-parts":[[1980,12,1]]}}}