{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:22:12Z","timestamp":1790428932067,"version":"4.1.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"663","license":[{"start":{"date-parts":[[1981,1,1]],"date-time":"1981-01-01T00:00:00Z","timestamp":347155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The results of treating 143 patients with trigeminal neuralgia with carbamazepine (CBZ) over a 16-year period have been reviewed. The drug was effective initially with few mild side effects in 99 patients (69%). Of these, 19 developed resistance later, i.e. between 2 months and 10 years after commencing treatment, and required alternative measures. Of the remaining 80 (56%), the drug was effective in 49 for 1-4 years and in 31 for 5-16 years. Thirty-six patients (25%) failed to respond to CBZ initially and required alternative measures, as did 8 (6%) who were intolerant of the drug. One patient developed CBZ-induced water intoxication with hyponatraemia. Subsequently hyponatraemia was excluded in 17 patients who had been taking CBZ for between 4 months and 7 years. This study has thus confirmed the efficacy of CBZ in the treatment of trigeminal neuralgia and shown that it may continue to be effective for many years.<\/jats:p>","DOI":"10.1136\/pgmj.57.663.16","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"16-18","source":"Crossref","is-referenced-by-count":196,"title":["Long-term treatment of trigeminal neuralgia with carbamazepine"],"prefix":"10.1093","volume":"57","author":[{"given":"J C","family":"Taylor","sequence":"first","affiliation":[{"name":"Regional Department of Neurosurgery and Neurology, Derbyshire Royal Infirmary , Derby"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Brauer","sequence":"additional","affiliation":[{"name":"Regional Department of Neurosurgery and Neurology, Derbyshire Royal Infirmary , Derby"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L E","family":"Espir","sequence":"additional","affiliation":[{"name":"Regional Department of Neurosurgery and Neurology, Derbyshire Royal Infirmary , Derby"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1981,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1136\/bmj.1.6069.1134","article-title":"Water intoxication associated with carbamazepine treatment","volume":"1","author":"ASHTON, M.G.; BALL, S.G.; THOMAS, T.H.; LEE, M.R.","year":"1977","unstructured":"ASHTON, M.G., BALL, S.G., THOMAS, T.H. & LEE, M.R. 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Hans Huber, Berne, Stuttgart, Vienna."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1136\/bmj.1.5481.210","article-title":"Treatment of trigeminal neuralgia with carbamazepine; a follow-up study","volume":"1","author":"GRAHAM, J.G.; ZILKHA, K.J.","year":"1966","unstructured":"GRAHAM, J.G. & ZILKHA, K.J. (1966) Treatment of trigeminal neuralgia with carbamazepine; a follow-up study. British Medical Journal, 1, 210.","journal-title":"British Medical Journal"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1526-4610.1969.hed0901064.x","article-title":"A long-term low dosage study of carbamazepine in trigeminal neuralgia","volume":"2","author":"LLOYD-SMITH, D.L.; SACHDEV, K.K.","year":"1969","unstructured":"LLOYD-SMITH, D.L. & SACHDEV, K.K. (1969) A long-term low dosage study of carbamazepine in trigeminal neuralgia. 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Practitioner, 192, 71.","journal-title":"Practitioner"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1136\/bmj.1.6125.1445","article-title":"Plasma arginine vasopressin concentrations and anti-diuretic action of carbamazepine","volume":"1","author":"STEPHENS, W.P.; COE, J.Y.; BAYLIS, P.H.","year":"1978","unstructured":"STEPHENS, W.P., COE, J.Y. & BAYLIS, P.H. (1978) Plasma arginine vasopressin concentrations and anti-diuretic action of carbamazepine. British Medical Journal, 1, 1445.","journal-title":"British Medical Journal"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1136\/bmj.1.6063.754","article-title":"Water intoxication due to carbamazepine","volume":"1","author":"STEPHENS, W.P.; EsPIR, M.L.E.; TATTERSALL, R.B.; QUINN, N.P.; GLADWELL, S.R.F.; GALBRAITH, A.W.; REYNOLDS, E.H.","year":"1977","unstructured":"STEPHENS, W.P., EsPIR, M.L.E., TATTERSALL, R.B., QUINN, N.P., GLADWELL, S.R.F., GALBRAITH, A.W. & REYNOLDS, E.H. 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