{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T16:11:02Z","timestamp":1683735062246},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"663","license":[{"start":{"date-parts":[[1981,1,1]],"date-time":"1981-01-01T00:00:00Z","timestamp":347155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Seventeen adult patients with previously untreated acute lymphoblastic leukaemia (ALL) were entered into a schedule of chemotherapy in which 3 combinations, each of 4 drugs, were administered in a predetermined cyclical rotation in combination with cranial irradiation and intrathecal injections of methotrexate. Of the 17 patients, 16 completed induction therapy and 15 (94%) entered remission. The only patient with T-ALL died before receiving any therapy. The median survival for all patients (17) was 22 months. Meningeal leukaemia did not occur during the haematological remission phase although 3 patients developed this complication following relapse. The authors conclude that the addition of cyclophosphamide and cytosine arabinoside to vincristine\/prednisone provides excellent remission induction but the aggressive maintenance schedule employed has not led to significant long-term survival.<\/jats:p>","DOI":"10.1136\/pgmj.57.663.19","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"19-22","source":"Crossref","is-referenced-by-count":3,"title":["Treatment of adult lymphoblastic leukaemia using cyclical chemotherapy with three combinations of four drugs (COAP, POMP, TRAP schedule)"],"prefix":"10.1093","volume":"57","author":[{"given":"S J","family":"Proctor","sequence":"first","affiliation":[{"name":"Department of Haematology Royal Victoria Infirmary , Newcastle upon Tyne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Finney","sequence":"additional","affiliation":[{"name":"Department of Haematology North Tees General Hospital , Newcastle upon Tyne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Victoria Infirmary , Newcastle upon Tyne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R B","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Victoria Infirmary , Newcastle upon Tyne"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1981,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0308-2261(78)80009-5","article-title":"Therapeutic role of cell kinetics in acute leukemia","volume":"7","author":"ARLIN, Z.A.; FRIED, J.; CLARKSON, B.D.","year":"1978","unstructured":"ARLIN, Z.A., FRIED, J. & CLARKSON, B.D. (1978) Therapeutic role of cell kinetics in acute leukemia. Clinics in Hematology, 7, 339.","journal-title":"Clinics in Hematology"},{"key":"ref_2","first-page":"793","article-title":"Treatment of acute lymphocytic leukemia (ALL) with high-dose methotrexate and L-asparaginase","volume":"15","author":"CAPIZZI, R. & CASTRO, 0","year":"1975","unstructured":"CAPIZZI, R. & CASTRO, 0. (1975) Treatment of acute lymphocytic leukemia (ALL) with high-dose methotrexate and L-asparaginase. Proceedings of the American Association for Cancer Research, 15, 793.","journal-title":"Proceedings of the American Association for Cancer Research"},{"key":"ref_3","first-page":"1307","article-title":"Acute lymphoblastic leukaemia in children: classification and prognosis","volume":"ii,","author":"CHESSELS, J.M.; HARDISTY, R.M.; ROPSON, N.T.; GREAVES, M.F.","year":"1977","unstructured":"CHESSELS, J.M., HARDISTY, R.M., ROPSON, N.T. & GREAVES, M.F. (1977) Acute lymphoblastic leukaemia in children: classification and prognosis. Lancet, ii, 1307.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/1097-0142(197508)36:2+<775::AID-CNCR2820360824>3.0.CO;2-V","article-title":"Treatment of acute leukemia in adults","volume":"36","author":"CLARKSON, B.D.; DOWLING, M.S.; GEE, T.S.; CUNNINGHAM, I.B.; BURCHENAL, J.H.","year":"1975","unstructured":"CLARKSON, B.D., DOWLING, M.S., GEE, T.S., CUNNINGHAM, I.B. & BURCHENAL, J.H. (1975) Treatment of acute leukemia in adults. 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Seminars in Hematology, 6, 271.","journal-title":"Seminars in Hematology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/bjc.1977.71","article-title":"Early central nervous system involvement in adults with non-myelogenous leukaemia","volume":"35","author":"LISTER, T.A.; Whitehouse, J.M.A.; BEARD, M.E.S.; PAXTON, A.; BREARLY, R.C.; BROWN, C.; WRIGLEY, P.F.M.; CROWTHER, D.","year":"1977","unstructured":"LISTER, T.A., Whitehouse, J.M.A., BEARD, M.E.S., PAXTON, A., BREARLY, R.C., BROWN, C., WRIGLEY, P.F.M. & CROWTHER, D. (1977) Early central nervous system involvement in adults with non-myelogenous leukaemia. 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