{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T16:10:58Z","timestamp":1683735058150},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"663","license":[{"start":{"date-parts":[[1981,1,1]],"date-time":"1981-01-01T00:00:00Z","timestamp":347155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The prevalence of thyroid antibodies was 2% among 53 healthy Shirazi volunteers, 3% among 30 consecutive patients with goitre, 41% among 17 patients with thyrotoxicosis and 67% among 18 consecutive patients with myxoedema. A surprising finding was that in a sub-group of 9 of the latter, a high incidence of diabetes (55%) was found and when both diseases co-existed, the prevalence of thyroid antibodies was 80% compared with 67% with myxoedema alone.<\/jats:p>\n               <jats:p>Serum cholesterol was marginally lower in the goitre than the control group (P, 0.05-0.025) but when females alone were compared there was no significant difference. It was also lower in the thyrotoxic group (P, 0.0025) and higher in the myxoedema group (P, 0.0025). Serum triiodothyronine was lower in the goitre group than the controls (P, 0.0005) but again, when females alone were considered, this difference lessened (P, 0.025-0.0125). Serum thyroxine and thyroid stimulating hormone levels showed no significant differences in the goitre and control groups.<\/jats:p>","DOI":"10.1136\/pgmj.57.663.23","type":"journal-article","created":{"date-parts":[[2008,12,29]],"date-time":"2008-12-29T20:43:59Z","timestamp":1230583439000},"page":"23-27","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of thyroid antibodies in Shiraz, Iran, an area with iodine deficiency"],"prefix":"10.1093","volume":"57","author":[{"given":"A A","family":"Khaleeli","sequence":"first","affiliation":[{"name":"Department of Human Metabolism, University College Hospital , London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1981,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1136\/bmj.2.6147.1253","article-title":"Evidence for a primary autoimmune type of diabetes mellitus","volume":"2","author":"BOTTAZZO, G.F.; CUDWORTH, A.G.; MOUL, D.J.; DONIACH, D.; FESTENSTEIN, H.","year":"1978","unstructured":"BOTTAZZO, G. F., CUDWORTH, A. G., MOUL, D. J., DONIACH, D. & FESTENSTEIN, H. (1978) Evidence for a primary autoimmune type of diabetes mellitus. British Medical Journal, 2, 1253.","journal-title":"British Medical Journal"},{"key":"ref_2","article-title":"Pancreatic autoimmunity and HLA antigens","volume":"800","author":"BOTTAZZO, G.F.; DONIACH, D.","year":"1976","unstructured":"BOTTAZZO, G.F. & DONIACH, D. (1976). Pancreatic autoimmunity and HLA antigens. Lancet, ii, 800.","journal-title":"Lancet"},{"key":"ref_3","article-title":"Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies","author":"BOTTAZZO, G.F.; FLORIN-CHRISTENSEN, A.; DONIACH, D.","year":"1974","unstructured":"BOTTAZZO, G.F., FLORIN-CHRISTENSEN, A. & DONIACH, D. (1974) Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet,;;, 1279.","journal-title":"Lancet"},{"key":"ref_4","first-page":"132","article-title":"The spectrum of iodine malnutrition and suggested management","volume":"2","author":"CAUGHEY, J.E.","year":"1971","unstructured":"CAUGHEY, J.E. (1971) The spectrum of iodine malnutrition and suggested management. Pahlavi (now Shiraz) Medical Journal, 2, 132.","journal-title":"Pahlavi (now Shiraz) Medical Journal"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1210\/jcem-40-2-326","article-title":"Serum thyroid hormone and thyrotrophin levels in subjects from endemic goitre regions of New Guinea","volume":"40","author":"CHOPRA, I.J.; HERSCHMANN, J.M.; HORNABROOK, R.W.","year":"1975","unstructured":"CHOPRA, I.J., HERSCHMANN, J.M. & HORNABROOK, R.W. (1975) Serum thyroid hormone and thyrotrophin levels in subjects from endemic goitre regions of New Guinea. 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Diabetologia, 14, 281.","journal-title":"Diabetologia"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1210\/jcem-34-5-891","article-title":"Circulating thyroid hormones in endemic goitre","volume":"34","author":"DELANGE, F.; CAMUS, M.; ERMANS, A.M.","year":"1972","unstructured":"DELANGE, F., CAMUS, M. & ERMANS, A.M. (1972a) Circulating thyroid hormones in endemic goitre. Journal of Clinical Endocrinology and Metabolism, 34, 891.","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"ref_9","first-page":"175","article-title":"A survey of the clinical and metabolic patterns of endemic cretinism. In: Human Development and the Thyroid Gland, Relation to Endemic Cretinism","author":"DELANGE, F.; COSTA, A.; ERMANS, A.M.; IBBERTSON, H.K.; QUERIDO, A.; STANBURY, J.B.","year":"1972","unstructured":"DELANGE, F., COSTA, A., ERMANS, A.M., IBBERTSON, H.K., QUERIDO, A. & STANBURY, J.B. (1972b) A survey of the clinical and metabolic patterns of endemic cretinism. In: Human Development and the Thyroid Gland, Relation to Endemic Cretinism, p. 175. Plenum. New York."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1210\/jcem-33-2-261","article-title":"Relationship between serum thyrotrophin levels, the prevalence of goitre and the pattern of iodine metabolism in the Idijiwi islands","volume":"33","author":"DELANGE, F.; HERSCHMANN, J.M.; ERMANS, A.M.","year":"1971","unstructured":"DELANGE, F., HERSCHMANN, J.M. & ERMANS, A.M. (1971) Relationship between serum thyrotrophin levels, the prevalence of goitre and the pattern of iodine metabolism in the Idijiwi islands. 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(1979) Endemic goitre and cretinism."},{"key":"ref_14","first-page":"1529","article-title":"Autoantibodies to pancreatic islet cells in insulin dependent diabetes with coexistent autoimmune disease","volume":"ii,","author":"MACCUISH, A.C.; BARNES, E.W.; IRVINE, W.H.; DUNCAN, L.J.P.","year":"1974","unstructured":"MACCUISH, A.C., BARNES, E.W., IRVINE, W.H. & DUNCAN, L.J.P. (1974) Autoantibodies to pancreatic islet cells in insulin dependent diabetes with coexistent autoimmune disease. Lancet, ii, 1529.","journal-title":"Lancet"},{"key":"ref_15","author":"MALAMOS, B.; KOUTRAS, D.A.; RIGOPOULOS, G.A.; PAPAPETROU, P.D.; GOUGAS, E.; KELPERI, H.; MORAITO-POULOS, C.; DAVI, E.; LEONARDOPOULOS, J.","year":"1971","unstructured":"MALAMOS, B., KOUTRAS, D.A., RIGOPOULOS, G.A., PAPAPETROU, P.D., GOUGAS, E., KELPERI, H., MORAITO-POULOS, C., DAVI, E. & LEONARDOPOULOS, J. (1971)"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1210\/jcem-32-2-130","article-title":"Endemic goitre in Greece: some new epidemiological studies","volume":"32","unstructured":"Endemic goitre in Greece: some new epidemiological studies. Journal of Clinical Endocrinology, 32, 130.","journal-title":"Journal of Clinical Endocrinology"},{"key":"ref_17","article-title":"HLA antigens and diabetes mellitus","volume":"864","author":"NERUP, J.; PLATZ, P.; ANDERSON, O.O.; CHRISTY, M.; LYNGSOE, J.; POULSEN, J.E.; RYDER, L.P.; THOMSON, M.; NIELSEN, S.T.A.U.B.; L.; SVEJGAARD, A.","year":"1974","unstructured":"NERUP, J., PLATZ, P., ANDERSON, O.O., CHRISTY, M., LYNGSOE, J., POULSEN, J.E., RYDER, L.P., THOMSON, M., STAUB NIELSEN, L. & SVEJGAARD, A. (1974) HLA antigens and diabetes mellitus. Lancet, ii, 864.","journal-title":"Lancet"},{"key":"ref_18","first-page":"14","article-title":"Thyroid function tests in Shiraz, Iran","volume":"5","author":"OLWEN-WILLIAMS, J.; HAMMICK, J.W.","year":"1974","unstructured":"OLWEN-WILLIAMS, J. & HAMMICK, J.W. (1974) Thyroid function tests in Shiraz, Iran. Pahlavi (now Shiraz) Medical Journal, 5, 14.","journal-title":"Pahlavi (now Shiraz) Medical Journal"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1210\/jcem-37-5-783","article-title":"Serum triiodothyronine, thyroxine and thyroid stimulating hormone in endemic goitre: a comparison of goitrous and non-goitrous subjects in New Guinea","volume":"37","author":"PATEL, Y.C.; PHAROAH, P.O.D.; HORNABROOK, R.W.; HETZEL, B.S.","year":"1973","unstructured":"PATEL, Y.C., PHAROAH, P.O.D., HORNABROOK, R.W. & HETZEL, B.S. 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Clinical Endocrinology, 7, 481.","journal-title":"Clinical Endocrinology"}],"container-title":["Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/57\/663\/23\/50216010\/postgradmedj-57-23.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pmj\/article-pdf\/57\/663\/23\/50216010\/postgradmedj-57-23.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T15:54:34Z","timestamp":1683734074000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pmj\/article\/57\/663\/23\/7153750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1,1]]},"references-count":22,"journal-issue":{"issue":"663","published-online":{"date-parts":[[1981,1,1]]},"published-print":{"date-parts":[[1981,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/pgmj.57.663.23","relation":{},"ISSN":["0032-5473","1469-0756"],"issn-type":[{"value":"0032-5473","type":"print"},{"value":"1469-0756","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1981,1]]},"published":{"date-parts":[[1981,1,1]]}}}